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VEGF stimulates activation of ERK5 in the absence of C-terminal phosphorylation preventing nuclear localization and facilitating AKT activation in endothelial cells
Get PDFYesExtracellular-signal-regulated kinase 5 (ERK5) is critical for normal cardiovascular development. Previous studies have defined a canonical pathway for ERK5 activation, showing that ligand stimulation leads to MEK5 activation resulting in dual phosphorylation of ERK5 on Thr218/Tyr220 residues within the activation loop. ERK5 then undergoes a conformational change, facilitating phosphorylation on residues in the C-terminal domain and translocation to the nucleus where it regulates MEF2 transcriptional activity. Our previous research into the importance of ERK5 in endothelial cells highlighted its role in VEGF-mediated tubular morphogenesis and cell survival, suggesting that ERK5 played a unique role in endothelial cells. Our current data show that in contrast to EGF-stimulated HeLa cells, VEGF-mediated ERK5 activation in human dermal microvascular endothelial cells (HDMECs) does not result in C-terminal phosphorylation of ERK5 and translocation to the nucleus, but instead to a more plasma membrane/cytoplasmic localisation. Furthermore, the use of small-molecule inhibitors to MEK5 and ERK5 shows that instead of regulating MEF2 activity, VEGF-mediated ERK5 is important for regulating AKT activity. Our data define a novel pathway for ERK5 activation in endothelial cells leading to cell survival.This research was funded by grants from: North West Cancer Research (NWCR): M.J.C. and A.K.M.; Medical Research Council (MRC DiMeN PhD): M.J.C. and K.A.; Biotechnology and Biological Sciences Research Council (BBSRC DTG Studentship): M.J.C., C.E.P.G., B.W. and G.N.N.; and Wellcome Trust Institutional Strategic Fund: M.J.C. and A.K.M
Assessing the impact of big data analytics on decision-making processes, forecasting, and performance of a firm
Get PDFYesThere are various kinds of applications of BDA in the firms. Not many studies are there which deal with the impact of BDA towards issues like forecasting, decision-making, as well as performance of the firms simultaneously. So, there exists a gap in the research. In such a background, this study aims at examining the impacts of BDA on the process of decision-making, forecasting, as well as firm performance. Using resource-based view (RBV) as well as dynamic capability view (DCV) and related research studies, a research model was proposed conceptually. This conceptual model was validated taking help of PLS-SEM approach considering 366 respondents from Indian firms. This study has highlighted that smart decision making and accurate forecasting process can be achieved by using BDA. This research has demonstrated that there is a considerable influence of adoption of BDA on decision making process, forecasting process, as well as overall firm performance. However, the present study suffers from the fact that the study results depend on the cross-sectional data which could invite defects of causality and endogeneity bias. The present research work also found that there is no impact of different control variables on the firm's performance
The impact of compliance, board committees and insider CEOs on firm survival during crisis
Get PDFYesThis study investigates the relationship between internal corporate governance mechanisms and firm survival during a financial crisis. Using a sample of FTSE 350 listed companies for the time period 2003–2010, our results show significant differences in the corporate governance mechanisms of firms that survived and those that failed during the 2007–2009 financial crisis. The findings indicate that compliance with the UK Corporate Governance Code is negatively associated with the survival of firms when they experience exogenous shocks. However, the existence of insider CEOs and a higher number of board committees in organisations increase the chances of survival during an economic downturn. These findings have policy implications and show that non-compliance with a prescribed code of corporate governance does not necessarily lead to poor governance. Moreover, the establishment of extra board committees and CEO succession planning are shown as important dynamics in firms’ strategic decisions, as they have implications for the survival of firms during difficult economic conditions
Compliance to GDPR Data Protection and Privacy in Artificial Intelligence Technology: Legal and Ethical Ramifications in Malaysia
No full textNoAI is becoming increasingly important in cybersecurity. AI-based products detect risks and secure systems and data. Cybercriminals can use technology to launch more sophisticated attacks. AI-based security is in demand due to cyberattacks. With the adoption of AI technology, GDPR requires most countries to have legal measures to protect their citizens' data and privacy. Data protection and privacy issues arise when using AI technology. AI use must comply with GDPR, including obtaining consent for data processing, ensuring data accuracy, and giving individuals the right to access, correct, or delete their data. Organisations must also be transparent about how their AI makes decisions and not discriminate against individuals or groups. This study examines Malaysia's GDPR compliance on AI usage, data protection, and privacy in light of current concerns. This study analyses primary and secondary sources using doctrinal research. In 2022, Malaysia's banking, healthcare, and telecommunications sectors were hit by data breaches, indicating that AI is increasing data breaches. Thus, the government must examine citizen data protection and privacy concerns and re-examine its governance, including legal and regulatory mechanisms, to see if it conforms to international norms and consider reforms.This research was supported by the Ministry of Education (MOE) through the Fundamental Research Grant Scheme (FRGS/1/2020/SSI0/UPSI/02/12)
Disruptive AI technology and hate speech: A legal redress in Malaysia
No full textNoArtificial intelligence (AI) technology is becoming increasingly prevalent in society, offering a range of benefits and opportunities. However, with the rise of AI comes new challenges, particularly in hate speech. Hate speech, a type of expression that incites hatred or violence against individuals or groups based on ethnicity, religion, or other characteristics, has become a growing concern in Malaysia, with social media and online platforms becoming a breeding ground for such speech. In this context, AI technology has emerged as a potential solution for monitoring and regulating hate speech, but it also presents legal and ethical challenges that must be addressed. In view of double edge sword roles played by the development of AI, this article analyses the legal recourse available in Malaysia for disruptive AI technology and hate speech. The authors claim that AI systems are prone to errors and biases and that there is a risk of relying too much on such plans at the expense of human judgement. There are also concerns regarding the impact of AI on free expression and privacy rights. In addition, the author suggests that artificial intelligence be appropriately regulated to ensure that it is consistent with international human rights standards and national laws.This research was supported by the Ministry of Education (MOE) through the Fundamental Research Grant Scheme (FRGS/1/2020/SSI0/MSU/03/1)
Cloud-based augmented reality as a disruptive technology for Higher Education
No full textNoAugmented reality (AR) within the context of higher education is an approach to engage students with experiential learning by utilising AR technology. This paper discusses the process undertaken by a teacher in higher education in designing and implementing cloud-based AR lesson for the students. The methodology engaged was case study at one institution of higher learning in Malaysia. The AR teaching process involves six stages, beginning with the selection of the course, followed by selection of the topic, designing of the AR teaching plan and the implementation of the AR lesson. Upon completion of the implementation of the AR lesson, the teacher and students would provide reflection of their experiences. The process concludes by the improvement of the AR teaching plan by the teacher. The study found that cloud based has indeed disrupted higher education in terms of providing richer learning experiences to the students, as well as enhanced teaching practices for the teachers. Hopefully, this paper would provide insights into the practices of AR teaching and learning approach for teachers in general, and within the context of higher education in particular. It is also intended that the six-steps process outlined in this paper becomes a reference and be duplicated by teachers at large who might be interested to design and implement AR lessons for their own courses
When The Spying Stop: Recent Criminalisation Of Cyberstalking In Malaysia
No full textNoThe ubiquity of the ICT and the Internet has made them integral to our daily lives in the past two
decades, bringing numerous benefits and the risks of victimisation from various cybercrimes, including
cyber harassment and cyberstalking. Stalking is generally understood as unwanted or unsolicited
persistent and continuous following, pursuing, contacting, spying, harassing, threatening the victim,
and causing fear and apprehension. Unfortunately, given the seriousness of cyberstalking and its severe
and traumatic impacts on the victims, the existence of the law and any legal protection for victims
remains elusive and vague in the Malaysian legal landscape for decades until August this year
Chatbot in smartphone self-paced learning: A study on technology acceptance among older adults in Malaysia
No full textYesOlder adults use their smartphones to learn new material but few studies examined their learning with the presence of a chatbot in a smartphone. We developed a three-week self-paced learning module on three topics (chatbot, QR scanner, Google Drive) using their smartphone. Our aims were to examine participants’ self-paced learning accuracy while exploring older adults acceptance of the chatbot. Twelve participants participated in this study (Mage: 64.75 years) for three weeks at their homes individually. Results showed that they had low accuracy for the chatbot but higher accuracy for the other two. Qualitative analyses indicated that participants disliked the chatbot and that good clarity in our instructional videos and slides may have contributed to the low acceptance for the chatbot. Our findings indicated that self-paced learning is feasible with slides and videos only, and to create more chatbot-related assessments to increase chatbot usage.Newton Fund Institutional Links grant ID: 331745333
Effects of perceived social isolation, fear of social isolation and gratitude during COVID-19 pandemic on anxiety in Malaysia
Get PDFYesMany governments including Malaysia imposed movement restrictions as public health measure to minimize COVID-19 (coronavirus) risks. Due to prolonged isolation, poorer physical and mental health is expected in the general population. Our aims were to examine (1) the mediating role of perceived social isolation (SI) and fear of social isolation (FSI) on the relationship between gratitude and anxiety, and (2) to explore the moderating role of age, education and socioeconomic status (SES) on the mediation model. A total of 427 participants currently living in Malaysia (Mage = 37.90, SD = 16.51, 313 females) completed a survey on isolation, gratitude and anxiety during a period of national lockdown. Results showed that that those with higher gratitude reported having less SI and FSI and less anxiety (Model 1). In Model 2 with age as moderator, young adults (YA) and middle-aged adults (MA) who had higher gratitude experienced lower SI and in turn had lowered anxiety, but such mediating role of SI was not observed among older adults (OA). As for FSI, MA who had higher gratitude had lower FSI and also lower anxiety but this relationship was not observed in YA or OA. We also examined the role of education and SES as moderators in the parallel mediation analysis. Results showed that the indirect association of gratitude with anxiety via FI and FSI was moderated by both education and SES. Specifically, among those with low education levels (regardless of SES), those with higher gratitude had lower SI and FSI which in turn reduced anxiety. This relationship is similar for those with medium level of education and from low and middle level of SES as well. Our findings highlight the importance of having some coping mechanism e.g., gratitude and social connection during the pandemic to have higher wellbeing and quality of life, especially for MA sample and people from low education and SES background.Newton Fund Institutional Links grant ID: 331745333, under Newton-Ungku Omar Fund partnership to MHY; UK Department for Business, Energy and Industrial Strategy and Malaysian Industry-Government Group for High Technology (MIGHT); British Counci
The effect of aspirin and eicosapentaenoic acid on urinary biomarkers of prostaglandin E2 synthesis and platelet activation in participants of the seAFOod polyp prevention trial
Get PDFYesUrinary prostaglandin (PG) E metabolite (PGE-M) and 11-dehydro (d)-thromboxane (TX) B2 are biomarkers of cyclooxygenase-dependent prostanoid synthesis. We investigated (1) the effect of aspirin 300 mg daily and eicosapentaenoic acid (EPA) 2000 mg daily, alone and in combination, on urinary biomarker levels and, (2) whether urinary biomarker levels predicted colorectal polyp risk, during participation in the seAFOod polyp prevention trial. Urinary PGE-M and 11-d-TXB2 were measured by liquid chromatography-tandem mass spectrometry. The relationship between urinary biomarker levels and colorectal polyp outcomes was investigated using negative binomial (polyp number) and logistic (% with one or more polyps) regression models. Despite wide temporal variability in PGE-M and 11-d-TXB2 levels within individuals, both aspirin and, to a lesser extent, EPA decreased levels of both biomarkers (74% [P ≤ .001] and 8% [P ≤ .05] reduction in median 11-d-TXB2 values, respectively). In the placebo group, a high (quartile [Q] 2-4) baseline 11-d-TXB2 level predicted increased polyp number (incidence rate ratio [IRR] [95% CI] 2.26 [1.11,4.58]) and risk (odds ratio [95% CI] 3.56 [1.09,11.63]). A low (Q1) on-treatment 11-d-TXB2 level predicted reduced colorectal polyp number compared to placebo (IRR 0.34 [0.12,0.93] for combination aspirin and EPA treatment) compared to high on-treatment 11-d-TXB2 values (0.61 [0.34,1.11]). Aspirin and EPA both inhibit PGE-M and 11-d-TXB2 synthesis in keeping with shared in vivo cyclooxygenase inhibition. Colorectal polyp risk and treatment response prediction by 11-d-TXB2 is consistent with a role for platelet activation during early colorectal carcinogenesis. The use of urinary 11-d-TXB2 measurement for a precision approach to colorectal cancer risk prediction and chemoprevention requires prospective evaluation.Efficacy and Mechanism Evaluation Programme. Grant Number: NIHR128210. Cancer Research UK. Grant Number: C23434/A2493