118 research outputs found
De openbare orde als beperkingsgrond van de godsdienstvrijheid in de eerste Nederlandse grondwetten
Get PDFDe openbare orde als beperkingsgrond van de godsdienstvrijheid in de eerste Nederlandse grondwetten
Get PDFDe openbare orde als beperkingsgrond van de godsdienstvrijheid in de eerste Nederlandse grondwetten
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Dynamic organization of transcription-coupled DNA repair
Get PDFThe aim of the work described in this thesis is to gain more insight in the role of
the Cockayne Syndrome A (GSA) and B (CSB) proteins in the process of transcriptioncoupled
DNA repair and transcription. Using biochemical analysis and live cell studies we
investigated the molecular behavior of both proteins. First, we analyzed the chromatin
remodeling activity of CSB. Secondly, using green fluorescent protein (GFP) technology
(Chapter 4) and photobleaching we studied (i) the dynamic behavior of CSB in TCR and
transcription in living cells, (ii) the kinetics of GSA in TCR and its molecular connection
with the CSB protein and (iii) the cellular localization of CSB with respect to other nuclear
processes like transcription and mRNA processing
Genetic and epigenetic alterations that drive leukemic stem cell self-renewal
Get PDFAcute myeloid leukemia has emerged as a paradigm for the concept of the cancer stem cell. This hypothesis presumes that the disease is maintained by a rare population of leukemia-initiating stem cells which have acquired genetic or epigenetic changes. It is most likely that a single (epi)genetic event will not be sufficient to cause leukemia, but that a number of sequential events are required. Similar to normal hematopoietic stem cells, both intrinsic as well as extrinsic factors that arise from the bone marrow niche, provide essential cues that regulate cell fate decisions such as leukemic stem cell self-renewal and differentiation. In this chapter, we will review the genetic and epigenetic abnormalities that underlie the process of leukemic transformation, and will discuss which events potentially co-operate to induce leukemia.</p
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