2,705 research outputs found
Management of gestational hypertension and mild pre-eclampsia at term
Get PDFZwangerschapshypertensie en preëclampsie compliceren 6-8% van alle zwangerschappen en vormen in Nederland de belangrijkste oorzaak van maternale morbiditeit en mortaliteit. Vaak is het ziektebeeld mild en treedt op in de aterme periode. Soms ontstaan ernstige complicaties, zoals eclampsie, abruptio placentae of het HELLP-syndroom. Wereldwijd was er tot nu toe geen overeenstemming over het beste beleid bij deze aandoeningen. Inleiding van de baring zou enerzijds maternale complicaties kunnen reduceren, maar anderzijds de kans op een sectio caesarea kunnen verhogen.
Het eerste deel van dit proefschrift beschrijft een multicentrisch gerandomiseerde klinische studie (HYPITAT trial (HYpertension and Pre-eclampsia Intervention Trial At Term)), uitgevoerd binnen het Verloskundige Consortium (www.studies-obsgyn.nl/hypitat). Wij onderzochten wat beter is voor vrouwen met een milde zwangerschapsgerelateerde aterme hypertensie: inleiden of afwachten, met het oog op klinische effectiviteit, maternale kwaliteit van leven en kosten. Deze studie werd uitgevoerd in 38 Nederlandse ziekenhuizen. In totaal werden 756 vrouwen gerandomiseerd voor inleiden (n=377) of afwachten (n=379). De resultaten wijzen uit dat inleiden de kans op maternale complicaties verkleint (31% versus 44%; RR 0.71; p<0.001), inleiden een tendens laat zien van minder sectio caesarea (14% versus 19%; RR0.75; p=0.085) en inleiden gemiddeld 831 euro per patiënt goedkoper is dan afwachten. De neonatale uitkomst en de maternale kwaliteit van leven is gelijk tussen beide strategieën. Daarom adviseren wij een inleiding van de baring bij vrouwen met een zwangerschapshypertensie of milde preëclampsie na 37 weken zwangerschap.
Het tweede gedeelte van dit proefschrift beschrijft welke factoren een slechte maternale uitkomst bij vrouwen met een aterme zwangerschapshypertensie of milde preëclampsie kunnen voorspellen. Voor deze studies hebben wij gebruik van de HYPITAT database.
The impact of Dutch works councils according to managers
Get PDFAlthough works councils have, by and large, equally extensive legal rights in Germany and the Netherlands, this is the first econometric analysis that investigates the influence of Dutch works councils on firm performance. We use a nation-wide Dutch dataset with information on management’s perceptions of the works council’s impact on their firms’ efficiency and innovation. Inspired by the German study of Jirjahn and Smith (2006), we analyze which determinants influence management’s attitude toward employee participation in the Netherlands. We establish a preponderant influence emanating from the works council’s role attitude and management’s leadership style.works councils, managerial response, effectiveness, efficiency, innovation
Paths to justice in the Netherlands: looking for signs of social exclusion
Get PDFIn 2003 Genn's Paths to Justice study for the UK was replicated in the Netherlands. A survey was held among 3.500 citizens into their experiences with problems for which there might be a legal solution.The data were collected by internet questionnaires, which were addressed to a random sample of an internet panel. In this paper we present some major findings on: (1) the incidence of justiciable problems within the population; (2) the kind of strategies people choose to solve their problems; (3) the outcome of different strategies for resolving justiciable problems; (4) the public's perceptions of the legal system. More specifically, we study differences with respect to age, marital status, educational level, income level and social class, in order to shed some light on the role and scope of social exclusion. Our results suggest that access to justice in the Netherlands is not so much restricted by the supply of legal advice and the organisation of the legal system, as well as by insufficient social-psychological capabilities of the citizens concerned.Legal procedure, legal system, social exclusion
Onder het gezicht van de Eeuwigheid
No full textNaar aanleiding van: J.H. van den Berg, Metabletica van God; Pelckmans/Kok Agora, Kapellen/Kampen 1995, 223 pp.Naar aanleiding van: J.H. van den Berg, Metabletica van God; Pelckmans/Kok Agora, Kapellen/Kampen 1995, 223 pp
FIG. 1 in Taxonomy of Mexican and Central American Members of Solanum Series Conicibaccata (sect. Petota)
No full textFIG. 1. Alternative classifications of the Mexican and Central American species of Solanum series Conicibaccata.Published as part of Spooner, David M., Van Den Berg, Ronald G., Peña, Antonio Rivera-, Velguth, Peter, Rio, Alfonso Del & López, Alberto Salas-, 2001, Taxonomy of Mexican and Central American Members of Solanum Series Conicibaccata (sect. Petota), pp. 743-756 in Systematic Botany 26 (4) on page 744, DOI: 10.1043/0363-6445-26.4.743, http://zenodo.org/record/634125
FIG. 2 in Taxonomy of Mexican and Central American Members of Solanum Series Conicibaccata (sect. Petota)
No full textFIG. 2. Distributions of the Mexican and Central American species of Solanum series Conicibaccata.Published as part of Spooner, David M., Van Den Berg, Ronald G., Peña, Antonio Rivera-, Velguth, Peter, Rio, Alfonso Del & López, Alberto Salas-, 2001, Taxonomy of Mexican and Central American Members of Solanum Series Conicibaccata (sect. Petota), pp. 743-756 in Systematic Botany 26 (4) on page 745, DOI: 10.1043/0363-6445-26.4.743, http://zenodo.org/record/634125
How Effective are Unemployment Benefit Sanctions? Looking Beyond Unemployment Exit
Get PDFThis paper provides a comprehensive evaluation of benefit sanctions, i.e. temporary reductions in unemployment benefits as punishment for noncompliance with eligibility requirements. In addition to the effects on unemployment durations, we evaluate the effects on post-unemployment employment stability, on exits from the labor market and on earnings. In our analysis we use a rich set of Swiss register data which allow us to distinguish between ex ante effects, the effects of warnings and the effects of enforcement of benefit sanctions. Adopting a multivariate mixed proportional hazard approach to address selectivity, we find that both warnings and enforcement increase the job finding rate and the exit rate out of the labor force. Warnings do not affect subsequent employment stability but do reduce post-unemployment earnings. Actual benefit reductions lower the quality of post-unemployment jobs both in terms of job duration as well as in terms of earnings. The net effect of a benefit sanction on post-unemployment income is negative. Over a period of two years after leaving unemployment workers who got a benefit sanction imposed face a net income loss equivalent to 30 days of full pay due to the ex post effect. In addition to that, stricter monitoring may reduce net earnings by up to 4 days of pay for every unemployed worker due to the ex ante effect.Benefit sanctions;earnings effects;unemployment duration;competing-risk duration models
Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion
No full textIn modern societies, biodegradation of hydrophobic pollutants generated by industry is important for environmental and human health. In Gram-negative bacteria, biodegradation depends on facilitated diffusion of the pollutant substrates into the cell, mediated by specialised outer membrane (OM) channels. Here we show, via a combined experimental and computational approach, that the uptake of monoaromatic hydrocarbons such as toluene in Pseudomonas putida F1 (PpF1) occurs via lateral diffusion through FadL channels. Contrary to classical diffusion channels via which polar substrates move directly into the periplasmic space, PpF1 TodX and CymD direct their hydrophobic substrates into the OM via a lateral opening in the channel wall, bypassing the polar barrier formed by the lipopolysaccharide leaflet on the cell surface. Our study suggests that lateral diffusion of hydrophobic molecules is the modus operandi of all FadL channels, with potential implications for diverse areas such as biodegradation, quorum sensing and gut biolog
Stress, Coping, Adjustment and Health
No full textConsiderable evidence accumulated that personality differences predict important health outcomes, such as risk of heart disease, mortality, mental disorders and well-being. Psychologists have developed several theories for how and why these relationships exist, and offer ways to change health-harming behavioral patterns. Examples of health-related behaviors that associate with personality differences include drugs including tobacco or alcohol, but also eating and risk-taking behavior, and frustration tolerance and stress, which are pathways through which personality traits are linked to differences in adult mental health, and human longevity and disability. Although trait approaches may help identify who might benefit from risk reduction, they do not deliver much proof about what might be done about it. Understanding self-regulation and resilience processes is a central concern for promoting health, well-being and longevity. This chapter also covers disasters as natural experiments that can complement studies of personality differences using panel data and laboratory studies. Understanding how people handle stress and which factors and processes make some of us vulnerable and others surprisingly resilient is key to the human adjustment domain
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