453 research outputs found
Predictors and Dynamics of the Humoral and Cellular Immune Response to SARS-CoV-2 mRNA Vaccines in Hemodialysis Patients: A Multicenter Observational Study
No full textBackground Preliminary evidence suggests patients on hemodialysis have a blunted early serological response to SARS-CoV-2 vaccination. Optimizing the vaccination strategy in this population requires a thorough understanding of predictors and dynamics of humoral and cellular immune responses to differentSARS-CoV-2 vaccines.Methods This prospective multicenter study of 543 patients on hemodialysis and 75 healthy volunteers evaluated the immune responses at 4 or 5 weeks and 8 or 9 weeks after administration of the BNT162b2or mRNA-1273 vaccine, respectively. We assessed antiSARS-CoV-2 spike antibodies and T cell responses by IFN-? secretion of peripheral blood lymphocytes upon SARS-CoV-2 glycoprotein stimulation (QuantiFERON assay) and evaluated potential predictors of the responses.Results Compared with healthy volunteers, patients on hemodialysis had an incomplete, delayed humoral immune response and a blunted cellular immune response. Geometric mean antibody titers at both timepoints were significantly greater in patients vaccinated with mRNA-1273 versus BNT162b2, and a larger proportion of them achieved the threshold of 4160 AU/ml, corresponding with high neutralizing antibody titers in vitro(53.6% versus 31.8% at 8 or 9 weeks, P Conclusions The mRNA-1273 vaccine's greater immunogenicity may be related to its higher mRNA dose. This suggests a high-dose vaccine might improve the impaired immune response to SARS-CoV-2 vaccination in patients on hemodialysis.This research was supported by Amgen (DONATION-331036).
A. De Vriese and J. Van Praet designed the study; R. Caluw e, A. De Bel, A. De Vriese, P. Doubel, L. Heylen, M. Schoutteten, J. Van Praet, B. Van Vlem, and L. Viaene provided study materials or patients; D. De Bacquer, A. De Vriese, M. Reynders, and J. Van Praet analyzed the data; D. De Bacquer and J. Van Praet made the figures; A. De Vriese drafted the paper; D. De Bacquer, M. Reynders, and J. Van Praet revised it critically for important intellectual content; all authors approved the final version
of the manuscript. The authors are indebted to Tessa Acke, Manuela Caster, Evelyne Deglorie, Mirjam Demesmaecker, Suzanne Driessens, Inne Hoebrekx, Annelien Leunen, Carine Lowis, Isabel Moyaert, Danny Pauwels, Joris Penders, Melissa Renders, Carmen Reynders, Sofie Tombeur, Katrien Uyttersprot, Femke Van Den Berg, Kristel Van Varenbergh, Tine Verheyen, Manon Verhulst, and Sophie Vleeschouwers for their invaluable help in the collection of the patient data and analysis of the samples
Antiquarianism in the sixth century AD: Easing The shift from Rome to Constantinople
No full textOne of the fundamental sources of cultural unease in late antiquity was the fall of the western Roman Empire and the transmission of imperial power and prestige from Rome to Constantinople. Through a close reading of the antiquarianism of three authors – John Lydus (c. AD 490 – c. 565), Cassiodorus (c. AD 485 – c. 585) and John Malalas (c. AD 490 – c. 570) – this paper analyses how the distant past is used in sixth century sources as a platform to compare and discuss the moral legitimacy of Rome and Constantinople as capitals of the Roman Empire. The paper shall present two case studies ; the antiquarian scrutiny of the questionable character of Romulus, who founded Rome on the blood of his brother Remus, and the antiquarian analyses of the fate of the statues in Rome and Constantinople.Une source fondamentale du malaise culturel de l’Antiquité tardive fut la chute de l’Empire romain et la transmission du pouvoir et du prestige impérial de Rome à Constantinople. Cet article analyse, à travers une lecture attentive des textes antiquaires de trois auteurs – Jean le Lydien (c. 490 – c. 565 ap. J.-C.), Cassiodore (c. 485 – c. 585 ap. J.-C.) et Jean Malalas (c. 490 – c. 570 ap. J.-C.) – comment le passé lointain est utilisé dans les sources du sixième siècle comme une plateforme pour comparer et discuter la légitimité morale de Rome et de Constantinople comme les capitales de l’Empire romain. La contribution présentera deux études de cas ; l’examen antiquaire du caractère douteux de Romulus, qui a fondé Rome sur le sang de son frère Remus, et les analyses antiquaires du sort des statues à Rome et à Constantinople.De val van het West-romeinse rijk was, samen met de overdracht van keizerlijke macht en prestige van Rome naar Constantinopel, een fundamentele bron van cultureel ongenoegen in de late oudheid. Deze bijdrage zal, door middel van een detaillezing van de antiquarische teksten van drie auteurs (Johannes van Lydië (ca. 490 – ca. 565 n. C.), Cassiodorus (ca. 485 – ca. 585 n. C.) en Johannes Malalas (c. 490 – c. 570 n. C.)) analyseren hoe het verre verleden in zesde-eeuwse historische bronnen werd gebruikt als een arena waarin de morele legitimiteit van Rome en Constantinopel werden vergeleken en bediscussieerd. Deze bijdrage zal deze analyse maken door middel van twee casussen : de antiquarische bevraging van het twijfelachtig personage Romulus, dat Rome stichtte in het bloed van zijn broer Remus, en de antiquarische analyses van de lotsbestemming van de standbeelden van Rome en Constantinopel.Praet Raf. Antiquarianism in the sixth century AD: Easing The shift from Rome to Constantinople. In: Revue belge de philologie et d'histoire, tome 96, fasc. 3, 2018. Antiquité - Ouheid. pp. 1011-1031
Catalogue des livres du cabinet de feu Messire Pierre-François-Vincent vicomte de Vooght : chevalier du Saint-Empire romain, seigneur de Kruys-Eecke, Barizeele, ten Dooren, Burémont, Erkegem, &c., grand-bailli de la ville et du pays et territoire du franc de Bruges : dont la vente se fera en sa maison ... le 13 mai 1782, & jours suivans ... /
No full textIncludes schedule of sale (p. xiij).1407 lots.Title vignette; head- and tail-pieces.Final page blank.Signatures: pi² a⁶ A-I⁸ (pi2 forms p. xiij-xiv).Blogie, J. RépertoireDate of sale: May 13-17, 1782.Place of sale: Brussels.Mode of access: Internet.Library's copy is bound with: Catalogue de tableaux, estampes, pastels et autres curiosités delaissé par feu Messire Pierre-François-Vincent vicomte de Vooght. A Bruges: Chez Joseph van Praet, Joseph de Busscher ..., [1782]Library's copy is interleaved with pages annotated with prices and totals in ms
Jaer-boek der keyzerlyke ende koninglyke hoofd-gilde van den edelen ridder Sint-Joris in den Oudenhove binnen de stad Brugge...
No full text[voorlopige beschrijving]Europeana-GoogleBook
Forecasting aggregate demand components with opinion surveys in the four main EC-countries - Experience with the BUSY model. Economic Papers No. 46, May 1986
No full text[catalog] Catalogue de livres choisies et curieux, tres-bien conditionnés, provenants de la bibliothèque de J. B. de M***, amateur des belles lettres : dont la vente se fera le mardi 13 Mai 1777 à l'Hôtel du Commerce à 10 heures du matin; & à 2 hures de revelé sous la dir. de Joseph Van Praet.
No full textGeannoteerd met prijzenLugtBijzondere collectiesEuropeana-GoogleBook
Identifying a consensus sample type to test for Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis and human papillomavirus
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Widespread occurrence of an emerging fungal pathogen in heavily traded Chinese urodelan species
No full textUnderstanding introduction routes for wildlife pathogens is vital for the development of threat abatement plans. The chytrid fungus Batrachochytrium salamandrivorans (Bsal) has recently emerged in Europe, where it is considered to be a serious threat for urodelan conservation. If the highly diverse Chinese urodelans were to constitute a Bsal reservoir, then the significant international trade in these species may vector Bsal into naïve urodelan communities. Here, we analyzed a total of 1,143 samples, representing 36 Chinese salamander species from 51 localities across southern China for the presence of Bsal. We found Bsal was present across a wide taxonomic, geographical, and environmental range. In particular, Bsal DNA was detected in 33 samples from the genera Cynops, Pachytriton, Paramesotriton, Tylototriton, and Andrias, including the heavily traded species Paramesotriton hongkongensis and Cynops orientalis. The true Bsal prevalence across our data set was estimated between 2% and 4%, with a maximum of 50% in a population of P. hongkongensis. Even at this overall relatively low Bsal prevalence, the exportation of millions of animals renders Bsal introduction in naïve, importing countries a near certainty, which calls for the urgent implementation of proper biosecurity in the international wildlife trade
Continuum of HIV care by key populations in Belgium: Cross-sectional and longitudinal views
No full textContinuum of HIV care by key populations in Belgium: Cross-sectional and longitudinal views
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