265 research outputs found
Impact of Measurement Data Time Resolution on Predicted Lifetime of PV Inverters in Residential Solar Panel Systems
No full textThe reliability of grid-tied PV inverters without integrated battery is compared with AC/DC-coupled PV- battery systems while varying the time resolution of the load and mission profiles (1 min – 60 min). Adding a battery increases self-consumption and can lower the needed grid power capacity in both DC- and AC-coupled configurations. A comparison between a battery-free PV system and a grid-tied PV-battery system shows that adding a battery to the system will not only improve the energy performance of the system but also increase the lifetime of the inverter (~15% in DC-coupled structure). The results have been extracted for two cases: (a) varying both mission profile and load profile resolutions, (b) varying the available load profile time resolution while keeping the mission profile time resolution constant at 1 min. The obtained results show that in our case, the influence of mission profile time resolution is greater than the input of load data. However, the expected PV inverter lifetime does not differ much for different time resolutions. This can highlight the importance of using measurement data with a resolution of even less than 1 minute because higher IGBT junction temperature swings can happen in a few seconds which cannot be seen in lower time resolutions
Worldwide coordination in a transnational environment: an inquiry into the work and careers of global managers..
No full textFIB Preparation of a NiO Wedge-Lamella and STEM X-Ray Microanalysis for the Determination of the Experimental k(O-Ni) Cliff-Lorimer Coefficient
No full textA method for the fabrication of a wedge-shaped thin NiO lamella by focused ion beam is reported. The starting sample is an oxidized bulk single crystalline, oriented, Ni commercial standard. The lamella is employed for the determination, by analytical electron microscopy at 200 kV of the experimental k(O-Ni) Cliff-Lorimer (G. Cliff & G. W. Lorimer, J Microsc 103, 203-207, 1975) coefficient, according to the extrapolation method by Van Cappellen (E. Van Cappellen, Microsc Microstruct Microanal 1, 1-22, 1990). The result thus obtained is compared to the theoretical k(O-Ni) values either implemented into the commercial software for X-ray microanalysis quantification of the scanning transmission electron microscopy/energy dispersive spectrometry equipment or calculated by the Monte Carlo method. Significant differences among the three values are found. This confirms that for a reliable quantification of binary alloys containing light elements, the choice of the Cliff-Lorimer coefficients is crucial and experimental values are recommended
Religion and human flourishing
No full textCan religion promote human flourishing? Existing research says yes. However, this work has largely been done within ‘WEIRD’ and Christian contexts. Might the reasons why or the answer be different elsewhere? Here, we outline how religion can contribute to flourishing among individuals and cultures using a cross-cultural approach. In five sections, we cover how religion and culture shape meaning in life, character/virtue, positive emotion, social relationships, and physical/mental health. We emphasize how little these relationships have been studied around the world and why the relationship between religion and flourishing, especially, would be aided by a cross-cultural look. We close with future directions in the study of religion and flourishing, with special attention to how and why this relationship may vary across cultural and religious groups
Methane efflux from marine sediments in passive and active margins: Estimations from bioenergetic reaction-transport simulations
No full textA simplified version of a kinetic–bioenergetic reaction model for anaerobic oxidation of methane (AOM) in marine sediments [Dale, A.W., Regnier, P., Van Cappellen, P., 2006. Bioenergetic controls on anaerobic oxidation of methane (AOM) in coastal marine sediments: a theoretical analysis. Am. J. Sci. 306, 246–294.] is used to assess the impact of transport processes on biomass distributions, AOM rates and methane release fluxes from the sea floor. The model explicitly represents the functional microbial groups and the kinetic and bioenergetic limitations of the microbial metabolic pathways involved in AOM. Model simulations illustrate the dominant control exerted by the transport regime on the activity and abundance of AOM communities. Upward fluid flow at active seep systems restricts AOM to a narrow subsurface reaction zone and sustains high rates of methane oxidation. In contrast, pore-water transport dominated by molecular diffusion leads to deeper and broader zones of AOM, characterized by much lower rates and biomasses. Under steady-state conditions, less than 1% of the upward dissolved methane flux reaches the water column, irrespective of the transport regime. However, a sudden increase in the advective flux of dissolved methane, for example as a result of the destabilization of methane hydrates, causes a transient efflux of methane from the sediment. The benthic efflux of dissolved methane is due to the slow growth kinetics of the AOM community and lasts on the order of 60 years. This time window is likely too short to allow for a significant escape of pore-water methane following a large scale gas hydrate dissolution event such as the one that may have accompanied the Paleocene/Eocene Thermal Maximum (PETM)
DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase
No full textWhen DNA is damaged in cells progressing through S phase, replication blockage can be avoided by TLS (Translesion DNA synthesis). This is an auxiliary replication mechanism that relies on the function of specialized polymerases that accomplish DNA damage bypass. Intriguingly, recent evidence has linked TLS polymerases to processes that can also take place outside S phase such as nucleotide excision repair (NER). Here we show that Pol eta is recruited to UV-induced DNA lesions in cells outside S phase including cells permanently arrested in G(1). This observation was confirmed by different strategies including global UV irradiation, local UV irradiation and local multi-photon laser irradiation of single nuclei in living cells. The potential connection between Pol eta recruitment to DNA lesions outside S phase and NER was further evaluated. Interestingly, the recruitment of Pol eta to damage sites outside S phase did not depend on active NER, as UV-induced focus formation occurred normally in XPA, XPG and XPF deficient fibroblasts. Our data reveals that the re-localization of the TLS polymerase Pol eta to photo-lesions might be temporally and mechanistically uncoupled from replicative DNA synthesis and from DNA damage processing.Fil: Soria, Ramiro Gasto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires; ArgentinaFil: Belluscio, Laura María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires; ArgentinaFil: van Cappellen, W. A.. Erasmus MC; Países BajosFil: Kanaar, Roland. Erasmus MC; Países BajosFil: Essers, Jeroen. Erasmus MC; Países BajosFil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires; Argentin
Early diagenesis of manganese, iron and phosphorus in European continental margin sediments
No full textThis thesis describes the results of a project that was carried out as a part of the
Sedimentary Manganese and Iron cycLEs (SMILE) research program funded by the
Netherlands Organisation of Scientific Research (NWO/ALW). SMILE aimed at
studying the biogeochemistry of iron and manganese cycles in sedimentary
environments along a carbon-loading gradient, i.e. from estuarine, via shelf and slope
sediments to deep-sea sediments. SMILE consists of three components, each
focussing on separate sedimentary environments; Mn and Fe cycling in estuarine
sediments (Netherlands Institute for Ecology, NIOO-CEMO), Atlantic shelf and slope
sediments (Netherlands Institute for Sea Research, NIOZ) and the Mediterranean
(Utrecht University- Institute for Earth Sciences, UU-IES). The SMILE objectives
include:
(1) to establish the role ofMn and Fe in the oxidation of organic matter,
(2) to examine the metal reduction rates as a function of organic carbon loading and
bioturbation,
(3) to investigate the interaction between Mn and Fe cycles and the phosphorus cycle,
and
(4) to study the formation and preservation of metal-rich layers and their geological
information.
The work presented here concentrated on Mn and Fe cycling as driven by the input of
organic matter and the recycling and burial of phosphorus in sediments of the
European continental margin. The problems were addressed by a combination of
fieldwork, laboratory work and modelling studies
Temporal beam pattern stability of a radio astronomy phased array feed
No full textA novel method to form multiple beams on the sky with a reflector antenna is to employ a dense phased array feed (PAF). This technology is currently being developed to greatly increase the survey speed of existing and future radio telescopes. For high quality radio astronomical images the beam patterns of the telescope must be stable over the duration of the observation, which is typically 12 hours for an East-West array. This is more complicated for a PAF than for a horn feed because the beams of a PAF are formed by adding the responses of multiple elements. Electronic gain variations of the receiver channels will lead to beam pattern variations. In contrast, the beam pattern of a horn feed is determined by mechanics only. First, the beam stability requirements are derived for the APERTIF system, a PAF system which will be installed on the Westerbork Synthesis Radio Telescope (WSRT). From these requirements the stability of the individual receiver channels is derived. Measurements during ∼3 hours demonstrate that the beam pattern stability of the existing horn feeds is according to the expectations. Good news is that the beam pattern of the PAF system is demonstrated to be equally stable during the same observation period under stable weather conditions
LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies
No full textLoss-of-function variants in the low-density lipoprotein receptor-related protein 10 (LRP10) gene have been associated with autosomal-dominant Parkinson’s disease (PD), PD dementia, and dementia with Lewy bodies (DLB). Moreover, LRP10 variants have been found in individuals diagnosed with progressive supranuclear palsy and amyotrophic lateral sclerosis. Despite this genetic evidence, little is known about the expression and function of LRP10 protein in the human brain under physiological or pathological conditions. To better understand how LRP10 variants lead to neurodegeneration, we first performed an in-depth characterisation of LRP10 expression in post-mortem brains and human-induced pluripotent stem cell (iPSC)-derived astrocytes and neurons from control subjects. In adult human brain, LRP10 is mainly expressed in astrocytes and neurovasculature but undetectable in neurons. Similarly, LRP10 is highly expressed in iPSC-derived astrocytes but cannot be observed in iPSC-derived neurons. In astrocytes, LRP10 is present at trans-Golgi network, plasma membrane, retromer, and early endosomes. Interestingly, LRP10 also partially co-localises and interacts with sortilin-related receptor 1 (SORL1). Furthermore, although LRP10 expression and localisation in the substantia nigra of most idiopathic PD and DLB patients and LRP10 variant carriers diagnosed with PD or DLB appeared unchanged compared to control subjects, significantly enlarged LRP10-positive vesicles were detected in a patient carrying the LRP10 p.Arg235Cys variant. Last, LRP10 was detected in Lewy bodies (LB) at late maturation stages in brains from idiopathic PD and DLB patients and in LRP10 variant carriers. In conclusion, high LRP10 expression in non-neuronal cells and undetectable levels in neurons of control subjects indicate that LRP10-mediated pathogenicity is initiated via cell non-autonomous mechanisms, potentially involving the interaction of LRP10 with SORL1 in vesicle trafficking pathways. Together with the specific pattern of LRP10 incorporation into mature LBs, these data support an important mechanistic role for disturbed vesicle trafficking and loss of LRP10 function in neurodegenerative diseases
Biogenic silica cycling in the upwelling area on the Somalian Margin
No full textThis thesis presents a study on the cycling and preservation of biogenic silica and
diatoms in the upwelling area on the Somali continental margin in the NW Indian
Ocean
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