25 research outputs found
A fast nonlinear model predictive control strategy for real-time motion control of mechanical systems
No full textMedical treatment and long-term outcome of chronic atrial fibrillation in the aged with chest distress: a retrospective analysis versus sinus rhythm
No full textYutao Guo, Lu Zhang, Chunjiang Wang, Yuexiang Zhao, Weiren Chen, Meng Gao, Ping Zhu, Tingshu Yang, Yutang WangDepartment of Geriatric Cardiology, General Hospital of The Chinese PLA, Beijing, 100853, People’s Republic of ChinaAbstract: Although “chest distress” is the most frequent complication in the aged with chronic atrial frbrillation (AF) in clinical practice, there are few data on the association between chronic AF and coronary artery disease (CAD) in the aged in terms of medical treatment and long-term outcome. We assessed coronary artery lesions in such patients and evaluated the efficacy of medical treatment in long-term follow-ups. Of 315 elderly patients (mean age: 77.39 ± 6.33 years) who had undergone coronary angiography for chest distress, 297 exhibited sinus rhythm (SR), whereas 18 patients exhibited chronic AF. Patients with AF were followed for 4.22 ± 2.21 years. Average diastolic blood pressure (DBP) of AF patients was observed to be markedly less than that of patients with SR (57.33 ± 6.87 mmHg vs 71.08 ± 10.54 mmHg, t-test: P < 0.01). Compared with SR patients, severe stenosis of the coronary artery in AF patients was reduced (73.06% vs 44.44%, Chi-square test: P < 0.01). AF patients with chest distress had high CHADS2 score (3.72 ± 1.27), but only 33.3% patients received oral anticoagulants, and such patients had a significantly lower rate of revascularization (21.43% vs 55.63%, Chi-square test: P < 0.01), and higher rate of all-cause death (22.22% vs 4.38%, Chi-square test: P < 0.01) and thromboembolism (16.67% vs 1.68%, Chi-square test: P < 0.01) in the long-term follow-ups compared with SR patients. Chest distress in the aged with AF was related to insufficient coronary blood supply that was primarily due to a reduced DBP rather than to occult CAD. Adequate and safe medical therapy was difficult to achieve in these patients. Such patients typically have a poor prognosis, and optimal therapeutic strategies to treat them are urgently needed.Keywords: aging, atrial fibrillation, coronary artery disease, antithrombotic therapy, revascularization, outcome 
Nutritional Control of L1 Arrest and Recovery in Caenorhabditis elegans by Insulin-like Peptides and Signaling
No full textAnimals must coordinate development with fluctuating nutrient availability. Nutrient availability governs post-embryonic development in Caenorhabditis elegans: larvae that hatch in the absence of food do not initiate post-embryonic development but enter "L1 arrest" (or "L1 diapause") and can survive starvation for weeks, while rapidly resume normal development once get fed. Insulin-like signaling (IIS) has been shown to be a key regulator of L1 arrest and recovery. However, the C. elegans genome encodes 40 insulin-like peptides (ILPs), and it is unknown which peptides participate in nutritional control of L1 arrest and recovery. Work in other contexts has identified putative receptor agonists and antagonists, but the extent of specificity versus redundancy is unclear beyond this distinction. We measured mRNA expression dynamics with high temporal resolution for all 40 insulin-like genes during entry into and recovery from L1 arrest. Nutrient availability influences expression of the majority of insulin-like genes, with variable dynamics suggesting complex regulation. We identified 13 candidate agonists and 8 candidate antagonists based on expression in response to nutrient availability. We selected ten candidate agonists (daf-28, ins-3, ins-4, ins-5, ins-6, ins-7, ins-9, ins-26, ins-33 and ins-35) for further characterization in L1 stage larvae. We used destabilized reporter genes to determine spatial expression patterns. Expression of candidate agonists was largely overlapping in L1 stage larvae, suggesting a role of the intestine, chemosensory neurons ASI and ASJ, and the interneuron PVT in systemic control of L1 development. Transcriptional regulation of candidate agonists was most significant in the intestine, as if nutrient uptake was a more important influence on transcription than sensory perception. Scanning in the 5' upstream promoter region of these 40 ILPs, We found that transcription factor PQM-1 and GATA putative binding sites are depleted in the promoter region of antagonists. A novel motif was also found to be over-represented in ILPs.Phenotypic analysis of single and compound deletion mutants did not reveal effects on L1 recovery/developmental dynamics, though simultaneous disruption of ins-4 and daf-28 extended survival of L1 arrest without enhancing thermal tolerance, while overexpression of ins-4, ins-6 or daf-28 shortened L1 survival. Simultaneous disruption of several ILPs showed a temperature independent, transient dauer phenotype. These results revealed the relative redundancy and specificity among agonistic ILPs.TGF- β and steroid hormone (SH) signaling have been reported to control the dauer formation along with IIS. Our preliminary results suggest they may also mediate the IIS control of L1 arrest and recovery, as the expression of several key components of TGF-β and SH signaling pathway genes are negatively regulated by DAF-16, and loss-of-function of these genes partially represses daf-16 null phenotype in L1 arrest, and causes a retardation in L1 development. In summary, my dissertation study focused on the IIS, characterized the dynamics and sites of ILPs expression in response to nutrient availability, revealed the function of specific agonistic ILPs in L1 arrest, and suggested potential cross-regulation among IIS, TGF-β signaling and SH signaling in controlling L1 arrest and recovery. These findings provide insights into how post-embryonic development is governed by insulin-like signaling and nutrient availability.</p
Computer based concurrent design and realization of simulated training system for marine electric propulsion system
No full textEvent-Triggered Intervention Framework for UAV-UGV Coordination Systems
No full textAir-ground coordination systems are usually composed of unmanned aerial vehicles (UAV) and unmanned ground vehicles (UGV). In such a system, UAVs can utilize their much more perceptive information to plan the path for UGVs. However, the correctness and accuracy of the planned route are often not guaranteed, and the communication and computation burdens increase with more sophisticated algorithms. This paper proposes a new type of air-ground coordination framework to enable UAVs intervention into UGVs tasks. An event-triggered mechanism in the null space behavior control (NSBC) framework is proposed to decide if an intervention is necessary and the timing of the intervention. Then, the problem of whether to accept the intervention is formulated as an integer programming problem and is solved using model predictive control (MPC). Simulation results show that the UAV can intervene in UGVs accurately and on time, and the UGVs can effectively decide whether to accept the intervention to get rid of troubles, thereby improving the intelligence of the air-ground coordination system
AMENDER: An Attentive and Aggregate Multi-layered Network for Dataset Recommendation
No full textIn this paper, we study the problem of recommending the appropriate datasets for authors, which is implemented to infer the proximity between authors and datasets by leveraging the information from a three-layered network, composed by authors, papers and datasets. To link author-dataset semantically by taking advantage of the rich content information of papers in the intermediate layer, we design an attentive and aggregate multi-layer network learning model. The aggregation is for integrating the intra-layer information of paper content and citations, while the attention is used for coordinating authors at the top-layer and datasets at the bottom-layer in the semantic space learned from papers in the intermediate layer. The experimental study demonstrates the superiority of our method compared with the solutions that extend existing models to our problem.The authors would like to thank the anonymous reviewers for their helpful comments. This work is supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, National Key Research and Development Program of China (2017YFB1002000), Science Technology and Innovation Commission of Shenzhen Municipality (JCYJ20180307123659504), and the State Key Laboratory of Software Development Environment in Beihang University
