1,207 research outputs found
Xiao-Yao-San, a Chinese Medicine Formula, Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat
No full textChronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with. The present study investigated the effect of Xiao-Yao-San (XYS), a traditional Chinese medicine formula used for treatment of gynecological disease, on the chronic stress-induced polycystic ovary and its underlying mechanism. Female Sprague-Dwaley rats underwent a 3 weeks chronic unpredictable mild stress (CUMS) procedure to establish the PCOS model, followed by 4 weeks treatment with XYS (0.505 g/kg or 1.01 g/kg) by gavage. Granulosa cells were exposed to noradrenaline (1 mM) in vitro for 24 h, followed by incubation with or without XYS-treated rat serum for 24 h. Post-treatment with XYS ameliorated CUMS-induced irregular estrous cycles and follicles development abnormalities, decrease of estradiol and progesterone level as well as increase of luteinizing hormone in serum, reduced cystic follicles formation and the apoptosis and autophagy of granulosa cells, attenuated the increase in dopamine beta hydroxylase and c-fos level in locus coeruleus, the noradrenaline level in serum and ovarian tissue, and the expression of beta 2 adrenergic receptor in ovarian tissue. Besides, XYS alleviated the reduction of phosphorylation of ribosomal protein S6 kinase polypeptide I and protein kinase B, as well as the increase of microtubule-associated protein light chain 3-I to microtubule-associated protein light chain 3-II conversion both in vi vo and in vitro. This study demonstrated XYS as a potential strategy for CUMS induced polycystic ovary, and suggested that the beneficial role of XYS was correlated with the regulation of the sympathetic nerve activity.Production of New Medicine Program of Ministry of Science and Technology of the People's Republic of China [2013ZX09402202]; State Key Laboratory of Core Technology in Innovative Chinese Medicine [20170034]SCI(E)ARTICLE
XIAO LI-HONG Novel Folk Writing
No full text[[abstract]]In the transition from the seventies to the eighties， female writers gradually monopolized the entire literary works. “Elegance literature” novel contents focusing on love between men and women and marriage are also referred as “women’s literature”. In order to re-examine female writers’ works and have them being offered with an objective literary status， the author has selected the representative XIAO LI-HONG as the research target among the female writers. Massive Taiwanese dialect， slang， proverb， tag line and song were being used in XIAO LI-HONG novel， showing the characteristics of “Taiwanese Novel”. Especially， strong feeling of nostalgia is being observed in the works， allowing hometown， Bu-Dai， to be revealed frequently. Using the relevant description of local customs and dialect way of writing， she has been able to unleash the authentic native of Taiwan in her deep memory of original hometown. In the “Osmanthus Alley” and “Qian Jiang You Shui Qian Jiang Yue” (Thousand Rivers and Moon)， early hometown identification has been recalled to reveal XIAO LI-HONG’s deep nostalgic feeling towards her homeland. Concept of reader homeland self-reflection and intention of constructing one’s spiritual homeland are intended to be triggered in the “White Lake Spring Dream”. Hometown provides her energy， triggering her incentive to explore childhood memory of hometown. The local customs of work， fresh and vivid Taiwan saying and elegant precision drafting are the typical characteristics of the language. Rich folk themes such as etiquette of life， worship of gods and ghosts， folk customs， revealing of folk wisdom， folk stories， along with the usage of folk songs and opera could create fresh sense of novel reading. What people speak is the local proverb， what being practiced is the folk belief， showing one’s spiritual living culture.
This paper is divided into four chapters， the first chapter， introduction， describes the motivation and purpose of study， scope and resource of study， previous research result， research method and structure， etc.. The second chapter describes the cultural characteristics of ordinary people. It could be broken down into four sections to introduce seasonal customs， folk life， disappearing industry， childhood toys and annual customs. Chapter three describes the analysis of local proverb， which could be separated into five categories: (1) numerology， (2) ways of doing in life， (3) family disciplinary， (4) philosophical life and (5) criticism. Chapter four is related to four-sentence rhyme， nursery rhyme， song and opera. It is divided into four sections to analyze the relationship of text plot with four-sentence rhyme， nursery rhyme， song and opera. Chapter five is the conclusion， which summarizes all chapters and sections to conclude XIAO LI-HONG style novel characteristics， and use various folk customs to reflect attitudes of people’s lives.
DWCox: A density-weighted Cox model for outlier-robust prediction of prostate cancer survival
No full textReliable predictions on the risk and survival time of prostate cancer patients based on their clinical records can help guide their treatment and provide hints about the disease mechanism. The Cox regression is currently a commonly accepted approach for such tasks in clinical applications. More complex methods, like ensemble approaches, have the potential of reaching better prediction accuracy at the cost of increased training difficulty and worse result interpretability. Better performance on a specific data set may also be obtained by extensive manual exploration in the data space, but such developed models are subject to overfitting and usually not directly applicable to a different data set. We propose \model, a density-weighted Cox model that has improved robustness against outliers and thus can provide more accurate predictions of prostate cancer survival. \Model~assigns weights to the training data according to their local kernel density in the feature space, and incorporates those weights into the partial likelihood function. A linear regression is then used to predict the actual survival times from the predicted risks. In \challengefull, \model~obtained the best average ranking in prediction accuracy on the risk and survival time. The success of \model~is remarkable given that it is one of the smallest and most interpretable models submitted to the challenge. In simulations, \model~performed consistently better than a standard Cox model when the training data contained many sparsely distributed outliers. Although developed for prostate cancer patients, \model~can be easily re-trained and applied to other survival analysis problems. \Model~is implemented in R and can be downloaded from https://github.com/JinfengXiao/DWCox.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-08-01The student, Jinfeng Xiao, accepted the attached license on 2018-07-13 at 16:11.The student, Jinfeng Xiao, submitted this Thesis for approval on 2018-07-13 at 16:18.This Thesis was approved for publication on 2018-07-16 at 08:49.DSpace SAF Submission Ingestion Package generated from Vireo submission #12874 on 2018-09-27 at 11:19:21Made available in DSpace on 2018-09-27T16:34:21Z (GMT). No. of bitstreams: 2
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Association and differences in genetic polymorphisms in PCSK9 gene in subjects with lacunar infarction in the Han and Uygur populations of Xinjiang Uygur Autonomous Region of China
No full textPolymorphisms in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene are associated with severe hypercholesterolemia and stroke. Here, we investigated the relationship between single nucleotide polymorphisms in PCSK9 and stroke in 237 patients with lacunar infarction in the Uygur and Han populations in Xinjiang Uygur Autonomous Region of China. Using the SNaPshot single-base terminal extension method, four PCSK9 gene polymorphisms were analyzed. We found a significantly strong relationship between the PCSK9 rs17111503 (G > A) polymorphism and increased susceptibility to lacunar infarction by variant homozygote comparison, and using the dominant and recessive models in the Han population but not in the Uygur population. Low triglyceride levels were found in AA carriers (rs17111503, G > A) in the Han population but not in the Uygur population. Association analysis revealed that the rs17111503 (G > A) polymorphism was not significantly associated with smoking, alcohol drinking, history of hypertension or diabetes in the Han or Uygur lacunar infarction patients. rs11583680, rs483462 and rs505151 were not associated with risk of lacunar infarction in the Han or Uygur populations. Our findings suggest that the PCSK9 rs17111503 (G > A) polymorphism is associated with susceptibility to lacunar infarction in the Han population but not in the Uygur population
Textual criticism of drawings in historical/scientific treatise on representation. The Caput in De prospectiva pingendi
No full textThe proposed article aims to provide a methodological contribution to reading historical/scientific treatise on representation. In philology, textual criticism is the critical analysis of literary texts aimed at a deep understanding of the text and the author’s intentions. In historical/scientific treatises on representation, the work is composed of two “texts” of equal importance: one is literary, the other graphic. In these cases therefore, textual criticism should be applied to both “texts” at the same time. The case study chosen to investigate the potential of the research method is the first illustrated treatise dedicated to perspective: De Prospectiva Pingendi by Piero della Francesca. While this is a work aimed at painters, the theoretical principles and applications of perspective are also addressed, contributing to a definition of the scientific basis of descriptive geometry. The bibliography is very rich, including essays by C. Winterberg (1899), G. Nicco Fasola (1942), M. Kemp (1994), and K. Andersen (2007). However, it should be noted that graphics that could explain the reasoning behind Piero della Francesca’s drawing are not always included, especially in critical editions. Among the pages of the treatise, proposition 8 in book III holds particular importance for the proposed investigation. Here, Piero constructs the perspective of a human head, which is first positioned straight (frontal position), and then looks upwards (generic position). This proposition represents a major step in that for the first and only time, the author addresses the theme of free forms. To read this proposition critically, it is necessary to refer to a hybrid digital model (polygonal mesh, T-Splines, and NURBS) developed by studying the codices housed in the Palatina Library in Parma and the Municipal Library in Bordeaux. Construction of the digital model allows us to understand both Piero’s refined spatial reasoning and its relative plane rendering in an original reverse path that highlights the scientific nature of the entire treatise and the potential of digital representation as applied to the textual criticism of drawings
An Improved Intrusion Detection System Based on Neural Network
No full textNeural network approach is an advanced methodology used for intrusion detection Adaptive Resonance Theory (ART) is one kind of neural networks featuring self-organization of stable recognition categories and on-line learning ART 2-A is a fast clustering algorithm of the ART family But ART 2-A cannot process categorical values, while network traffic data collected for intrusion detection always contain this kind of data An improved model of ART 2-A is thus proposed to deal with categorical data properly To verify the accuracy of this new model, experiments were carried out on the KDD Cup 99 data set Results showed that the performance of the new model was satisfactoryhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000284970100184&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Computer Science, Artificial IntelligenceEICPCI-S(ISTP)
The SMEs’ Internationalization Strategy --Foreign Market Entry Modes Selection
No full textThe SMEs’ internationalization strategy—Foreign Market Entry Modes selection Title: 1st of June 2006 Date of the Seminar: Bus 809. Master thesis in international marketing Course: Han xiao Author: Ulf Elg, Associate professor, Lund University, Sweden Advisors: Ying Bin, Associate professor, Zhongnan University of Economics and Law, China. Guest researcher, Lund University, Sweden Internationalization, entry mode, SMEs, foreign market Keywords: The purpose of this study is to understand the internationalization process of the SMEs, and try to define the motives and internal factors impact their foreign market entry mode selection. Thesis purpose: This thesis is based on qualitative method using case study. The primary information sources are the interviews with key-persons in internationalization process of SMEs Methodology: The literature review in this study concerns areas of SMEs’ motives for internationalization, foreign market entry mode approaches and influence of internal & external factors. Theoretical perspective: The empirical data consisted of case studies of two Chinese companies active within the packaging industry and located in east and south coast of China. In-depth Interviews were conducted in the semi-structure form. Empirical data: Findings show that the level of demand for SME’s products in foreign market is the major determinant for SMEs to go international. For the SMEs to be able to compete in the foreign market, they should have unique products with flexible pricing strategy. SMEs, due to their small size and limited resources, are more or less forced to use more simple and less costly entry modes, thus, most middle and small sized companies begin their internationalization with various forms of the export mode where less control and fewer resources to move abroad is needed
The Evolution of the Can Tang Wu-dai-shi Yan-yi --With some remarks on Xiao-shuo Jiang-shi--
No full textThe author intends to answer the following questions : (1) Why is Li Cun-xiao 李存孝 described as the hero of the Can Tang Wu-dai-shi Yan-yi 殘唐五代史演義? (2) Why is the Can Tang Wu-dai-shi Yan-yi detailed in the first half and sketchy in the second half? (3) Why is the Can Tang Wu-dai-shi Yan-yi completely different in contents from the Wu-dai-shi Ping-hua 五代史平話? Li Cun-xiao in the Can Tang Wu-dai-shi Yan-yi is an invincible general and the incarnation of loyalty and filial duty. This is not a reflection of the actual person in history. However, it is worth noting that in the novel Li Cun-xiao is executed without opposing, because he is deceived by Kang Jun-li 康君立 and Li Cun-xin 李存信 into believing the execution is ordered by his foster father Li Ke-yong 李克用. In history, Li Cun-xiao distinguished himself by bravery, but Li Ke-yong favoured Kang Jun-li, and Li Cun-xin made a false charge against Li Cun-xiao, so that Li Cun-xiao betrayed Li Ke-yong and was executed. More notably, the death of Li Cun-xiao is also described in Guan Han-qing's 關漢卿 play of Deng fu-ren ku-tong ku Cun-xiao 鄧夫人苦痛哭存孝, where the plot is similar to that of the novel but Li Cun-xiao deplores many times that he is treated coldly because of a foster child. These make it clear that the play is based on the historical fact and justifies Li Cun-xiao, and that the novel is based on the play and identifies him as a good son and retainer. This is a reflection of sympathy for Li Cun-xiao. We must not forget that Li Cun-xiao is not only in the novel but in all of Yuan Drama 元雜劇 about him described as a central figure in the battle against Huang Chao 黄巢, who was defeated by Li Ke-yong in history. This is another reflection of sympathy for Li Cun-xiao. The legend of Li Cun-xiao seems to have been embellished, connected with the legend of Huang Chao and Zhu Wen 朱溫 by Zheng-de 正德 period (1506-1521), and compiled into the lost Jin-tong Can Tang Ji 金統殘唐記. The Can Tang Wu-dai-shi Yan-yi, which seems to be based on the Jin-tong Can Tang Ji, was revised about 1613, in order to fill up the blank between the Sui Tang Liang-chao Zhi-zhuan 隋唐兩朝志傳 and the Nan-Song Zhi-zhuan 南宋志傳. The former describes the period before the rebellion of Huang Chao and the latter describes from the second half of the Five Dynasties 五代, which is based on the Wu-dai-shi Ping-hua. Therefore the Can Tang Wu-dai-shi Yan-yi need not describe the Five Dynasties in detail, so that it is only roughly treated in the second half. The Wu-dai-shi Ping-hua is mainly based on the Zi-zhi Tong-jian Gang-mu 資治通鑑綱目, so the content is entirely different from that of the Can Tang Wu-dai-shi Yan-yi. We can also find this kind of differnce among other historical novels such as Ping-hua 平話 in the Yuan 元 dynasty and Yan-yi 演義 in the Ming 明 dynasty. It is possible that this is derived from the difference between Xiao-shuo 小說 and Jiang-shi 講史 in the Song 宋 dynasty
Scale-to-scale energy transfer in mixing flow induced by the Richtmyer-Meshkov instability
No full textThe Richtmyer-Meshkov instability (RMI) mixing flow induced by a planar shock wave of Mach 1.6 is investigated using direct numerical simulation method. Interfacial perturbations of different scales between air and sulfur hexafluoride are introduced to study the effect of the initial conditions. Focus is placed on the analysis of the scale-to-scale transfer of kinetic energy in both Fourier and physical spaces. The kinetic energy injected from the perturbation scales is transferred to both larger and smaller scales in an average sense within the inner mixing zone (IMZ) at early times and is mainly passed down into smaller scales at the late stage. The physical-space energy flux due to the subgrid-scale (SGS) stress is studied using a filtering approach in order to shed light on the physical origin of the scale-to-scale kinetic energy transfer. It is found that the pointwise SGS energy flux is highly correlated with the local spike and bubble structures in the IMZ. Moreover, it turns out that the mean SGS energy flux is mainly ascribed to the component in the direction of shock wave propagation. An analysis using the method of conditional averaging manifests that the generation of local SGS energy flux is associated with the property of the surrounding flow induced by quadrupolar or dipolar vortex structures.National Natural Science Foundation of China [11372007, 11521091]; 973 Program [2013CB834100]SCI(E)[email protected]
Negative photoconductivity of InAs nanowire
No full textNegative photoconductivity is observed in InAs nanowires (NWs) without a surface defective layer. The negative photoconductivity is strongly dependent on the wavelength and intensity of the light, and is also sensitive to the environmental atmosphere. Two kinds of mechanisms are discerned to work together. One is related to gas adsorption, which is photodesorption of water molecules and photo-assisted chemisorption of O-2 molecules. The other one can be attributed to the photogating effect introduced by the native oxide layer outside the NWs.MOST [2012CB932702, 2012CB932701]; NSF of China [11374022, 61321001, 11528407]SCI(E)[email protected]
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