19 research outputs found
Una formulación tradicional de poli-hierbas mejora la función cognitiva en ratones C57BL / 6
Get PDFIntroducción: Khamira Gawzaban Ambari Jadwar Ood Saleeb Wala (KGAJOS) es una formulación de Unani compuesto de poliherbal descrito como tónico para el cerebro, corazón, hígado y estómago. Este estudio se realizó para evaluar la eficacia preclínica de KGAJOS en el aprendizaje y la memoria.Método: Se evaluó la actividad de mejora de la función cognitiva de KGAJOS utilizando la prueba de laberinto de agua de Morris en ratones C57BL / 6. Se utilizó piracetam como control positivo. Se utilizó el software de seguimiento de video Anymaze para rastrear la ruta.Resultados: Durante la prueba de la sonda, se observó un aumento significativo en el tiempo empleado en el cuadrante de la plataforma a 1000 y 1500 mg / kg de peso corporal de KGAJOS (p <0,01 y 0,001, respectivamente) y en el grupo de piracetam (p <0,01) en comparación con el control. La latencia para alcanzar el cuadrante de la plataforma (latencia de escape) se redujo significativamente (p <0,001) en el grupo de piracetam y KGAJOS a 1000 y 1500 mg / kg de peso corporal en comparación con el control.Conclusiones: El experimento del laberinto de agua de Morris reveló una mejora en la función de aprendizaje y memoria con 1000 y 1500 mg / kg de peso corporal de KGAJOS, mientras que 500 mg / kg de peso corporal no fue efectivo. La eficacia observada de KGAJOS confirmó las afirmaciones tradicionales y el uso de esta formulación en condiciones asociadas con la cognición y la memoria.
Standardization of Unani Drugs with Modern Analytical Parameters: A Necessary Step
No full textMankind have been always utilized their native flora, not only as a source of food but also use for shelter, fuel, clothing, chemical production and healthcare products since ancient time. Traditional medicine (Ayurveda, Naturopathy, Unani, Siddha, and Homeopathy) and Yoga are gaining more and more attention all over the world, because of their long historic clinical practice and minimum side effects. Unani system of medicine also a part of traditional medicine, it also gaining more acceptability around the world, but to get the quality of the crude drugs and Unani formulations is still facing lacking of standardization. In this respect internationally recognition related with the quality is necessary. This can be achieved only if the herbal products are evaluated and analyzed using modern scientific tool and technologies of standardization.
In this article discuss the various standardization parameters like morphological characters, microscopic evaluation, fluorescence analysis, physicochemical evaluations-proximate analysis (Moisture, ash content), solubility value (alcohol soluble, water soluble and ether soluble), heavy metal analysis and chromatography of botanicals are included. In the present review, various sensory parameters of the plant material (such as colour, odour, size, shape, and taste) were also mentioned of organoleptic evaluation method.
Key words: Herbal medicine, Standardization, Quality control, Chromatograph
EVALUATION OF ANTIARTHRITIC ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST FORMALDEHYDE-INDUCED ARTHRITIS IN RATS
Get PDFObjective: Schisandra grandiflora is a plant, reported for its variety of ethnic medicinal uses. The current study was undertaken to evaluate the antiarthritic activity of S. grandiflora against formaldehyde-induced arthritis in rats.
Methods: The plant powder successively extracted with water and subjected for phytochemical screening to identify the different phytochemical constituents. LD50 study is conducted for the aqueous extract up to the dose level of 2000 mg/kg by following the method of OECD guidelines no. 425.
Results: Preliminary phytochemical studies revealed the presence of terpenoids, flavonoids, alkaloids, and glycosides in aqueous extract of S. grandiflora. No mortality was observed with the aqueous up to the maximum dose level of 2000 mg/kg. Further, aqueous extracts at 100 and 200 mg/kg, p.o but not with 100 mg/kg p.o dose significant (p<0.01) reduced paw edema in formaldehyde-induced arthritis in rats.
Conclusion: The present study revealed the antiarthritic activity extract of S. grandiflora. Moreover, the activity is showed the presence of phytochemical constituents such as terpenoids, alkaloids, glycosides, and flavonoids as these phytochemical constituents
Therapeutic Potential of Widely Used Unani Drug Asl-Us-Soos (Glycyrrhiza glabra Linn.): A Systematic Review
No full textPlants have been one of the important sources of therapeutics or other human health benefits since the beginning of human civilization throughout history. Currently, there is increasing awareness and general acceptability of the use of herbs, as a medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Traditional system of medicine including Ayurveda, Unani, and Siddha etc. contributed in Health care dealing worldwide. The Unani system of medicine (USM) is an age old system of medicine which has a holistic approach to treat various kind of disease; most of the time the drugs mentioned in this system has tremendous effects in chronic disease.
Asl-Us-Soos (Glycyrrhiza glabra Linn), is a widely used herb in USM. Although the review articles on this plant are already published, this review article is presented to comply all the updated information on its therapeutic potency based on phytoconstituents and pharmacological activities and the potency which is described by renowned Unani physicians and scholars. The evidence based studies provides strengthen to the concept of Unani physicians as the Unani physician used and recommended the drug since along. Moreover the evidence based studies indicate that Glycyrrhiza glabra Linn possesses antibacterial, antioxidant, antimalarial, antispasmodic, expectorant, aphrodisiac, antimycobacterial activity, antiinflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antihepatotoxic, antifungal and herpes simplex have also been studies. These results are very encouraging and indicate that this Unani drug can be studies more extensively with a well-planned and systematic scientific preclinical and clinical approach to explore the promising outcome. Further this review gives an account of the current knowledge on the morphological characters, microscopic characters, phytochemistry, and pharmacological actions present in root of Glycyrrhiza glabra along with its actions and therapeutic potential in the perspective of USM.
Keywords: Glycyrrhiza glabra, therapeutic potential, US
Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity
No full textBackground: Cisplatin is extensively used in treating cancers, and its primary side-effect is nephrotoxicity. It accumulates in proximal convoluted tubules where it promotes cellular damage by oxidative stress, apoptosis, and inflammation, etc. In Unani medicine, Tukhm-e-Karafs (Apium graveolens L.) (TK) is mentioned in the literature to manage various kidney ailments due to its diuretic and deobstruent activities. Objective: To investigate the nephroprotective effects of powder of TK in Cisplatin-induced nephrotoxicity in an animal model and to validate the Unani claim of its nephroprotective action. Material and methods: In curative protocol, cisplatin (5 mg/kg body weight i.p) was administered on day one and powder of TK (500 and 1000 mg/kg p.o.) from the sixth day onwards for ten days. TK (500 and 1000 mg/kg p.o.) was given for ten days and Cisplatin (5 mg/kg body weight i.p) on day 11 in the protective model. At the end of the study, all the animals were sacrificed, and renal biochemical parameters were determined. KIM-1 level was also investigated in the kidney homogenate in conjunction with histopathological inspection of kidney tissues. Results: Significant increase in serum creatinine and BUN, presence of mononuclear cell infiltration, tubular dilation and vacuolation in renal histopathology, and increased KIM-1 level confirmed the nephrotoxicity due to Cisplatin. TK's administration protects the kidney as suggested by the changes in biochemical renal function, decreased level of KIM-1, and improvement in histopathological changes. Conclusion: The result advocated that TK prevented renal injury and maintained normal renal function in both models. It may be due to improved clearance of Cisplatin from kidney tubules and reduction in reactive oxygen species (ROS) produced by the inflammatory response
Study of Pakistan pilot project farmer-leaders to Nepal
Get PDFFarmer participation / Irrigation management / Farmer managed irrigation systems / Irrigated farming / Sustainable agriculture / Institution building / Pakistan
