100,492 research outputs found
Updates on coagulation testing
No full textSummary - This paper illustrates the difficulties of accurately assessing the coagulation profile due to the complexity of this system, which is strictly related to inflammatory conditions. Moreover, the classical interpretation of the blood coagulation cascade has been reviewed, and some new highlights pointed out. Currently, several tests are available to explore primary or secondary haemostasis as well as fibrinolysis. The decision to use a preliminary panel of tests readily accessible to veterinarians in practice is worthy. Tests included in the preliminary panel should give a basic interpretation in the several steps of coagulation with good sensitivity and specificity. Then, depending on the results obtained, more detailed assays could be used in order to characterize the defect or the exact deficiency in haemostasis
Leishmaniasis and tick borne diseases in dogs. Evaluation of the coagulation profile
No full textLeishmaniasis and tick borne diseases are disorders frequently detected in the Mediterranean area, and due to the increased movement of animals across Europe are increasingly recognized also in other countries. Moreover, the intermediate hosts of these pathogens (sandflies and ticks) are widely distributed in Europe due to climate changes over the last decades. A large program of research in tick borne diseases is currently under way and some aspects still remain to be explored in order to clarify the importance and spread of these disorders. In subclinical or asymptomatic dogs it is quite rare to detect involvement of the coagulation system. In clinically affected dogs, due both to the severe inflammation and immunological disarrangement, the hemostatic system is strongly solicited, cooperating in the disease progression, course and prognosis
Validation of an immunoturbidimetric D-dimer assay in canine citrated plasma
No full textD-dimer is a neoantigen formed when thrombin initiates the transformation of fibrinogen to fibrin; it is derived from plasmin digestion of cross-linked fibrin. In human medicine, the usefulness of this analyte in diagnosing disseminated intravascular coagulation (DIC) has been assessed in patients fulfilling the clini- cal and laboratory requirements for this disorder. In canine medicine, the use of D-dimer is relatively new. Detailed studies are needed to understand the relationship between D-dimer concentration in plasma and DIC status in dogs. We validated a D-dimer immunoturbidimetric assay (Tina-quant [a] D-Dimer, Boehringer Mannheim) in canine citrated plasma samples. Intra-assay and interassay variability (coefficient of variation) was 5.63% and 8.82%, respectively. The assay was linear, using 2 samples with low and high D-dimer concen- trations (r = .996 and .998). Accuracy was 102.2% and 95.7% based on a recovery study in which 2 samples were assessed. Reference values for D-dimer were established using 70 healthy dogs that were assessed clinically and evaluated on the basis of a complete laboratory workup. The reference range was set between 0.02 and 0.28 μg/mL (chi-square test for normal distribution, P > .05)
Connectionist speaker normalization with Generalized Resource Allocating Networks
No full textInter-speaker variability is one of the principal error sources in automatic speech recognition. This paper presents a rapid speaker-normalization technique based on neural network spectral mapping. The neural network is used as a front-end of a continuous speech recognition system (speaker-dependent, Hmm-based) to normalize the input acoustic data from a new speaker. The spectral difference between speakers can be reduced using a limited amount of new acoustic data (40 phonetically rich sentences). Recognition error of phone units from the acoustic-phonetic continuous speech corpus APASCI is decreased with an adaptability ratio of 25%. We used local basis networks of elliptical Gaussian kernels, with recursive allocation of units and on-line optimization of parameters (GRAN model). For this application, the model included a linear term. He results compare favorably with multivariate linear mapping based on constrained orthonormal transformation
Evaluation of the main poisoning in dogs in the period 2005-2015. Focus on the prevalence, clinical pathologic findings and neurological signs
No full textTo evaluate the cases of poisoning in dogs in 15 years of activity of a 24h Veterinary Clinic located in Padua, Nothr Italy
Urinary excretion of calcium and phosphate in dogs with pituitary-dependent hypercortisolism: Case control study in 499 dogs
No full textPituitary-dependent hypercortisolism (PDH) in dogs is frequently associated with high serum phosphate and parathormone concentrations which are in turn associated with prognosis and clinical presentation. The pathogenesis of such abnormalities remains unknown. The aim of the present study was to evaluate the serum and urinary concentrations and the urinary fractional excretion of phosphate and calcium in dogs with PDH. Medical records of newly diagnosed PDH dogs before treatment from one referral centre were retrospectively evaluated. One clinically normal and one sick dog for each dog with PDH were included as controls. One hundred and sixty-seven dogs with PDH were included. The serum phosphate concentration in PDH dogs was significantly (P0.0001) higher compared with clinically normal control dogs (CNDs) and sick control dogs (SCDs). The serum calcium concentration in PDH dogs was significantly higher compared with SCDs but not different compared with CNDs. Urinary fractional excretion of phosphate in PDH dogs was significantly lower compared with CNDs and SCDs. Urinary fractional excretion of calcium in PDH dogs was significantly higher compared with CNDs and SCDs. In conclusion, PDH dogs have lower phosphaturia and higher calciuria compared with control dogs. These findings suggest that, at least in part, high serum phosphate concentrations are related to the renal retention of phosphate
Evaluation of the main poisoning in dogs in the period 2005-2015. Focus on the prevalence, clinical pathologic findings and neurological signs
No full textTo evaluate the cases of poisoning in dogs in 15 years of activity of a 24h Veterinary Clinic located in Padua, Nothr Italy
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