1,721,639 research outputs found
Into the Fold. Drawings on the Move from the Sangallo Archive
Full text linkThis chapter proposes a new category for the classification of Renaissance architectural drawings by bringing attention - through a careful selection of examples from the archive of the Sangallo family - to plans, elevations, and surveys that were purposely realized be mailed, as a form of remote control of the building site or a means to share archeological knowledge
Building with Paper. Introduction
No full textIntroduction to the volume, addressing the question of archtectural drawing's materiality in the early modern ag
Torri di Parma: Aldo Rossi, Luigi Ghirri e la felicità dell’architettura
No full textIl rapporto tra l'architettura di Aldo Rossi e la fotografia di Luigi Ghirri è studiato attraverso il caso studio emblematico del Centro Torri di Parma, edificio realizzato e documentato fotograficamente alla fine degli anni ottanta, in un momento decisivo per la carriera di entrmabi gli autori
Giuliano da Sangallo e la «maniera moderna»
No full textRiesame del ruolo giocato da Giuliano da Sangallo, dalla sua opera e dal modello professionale da lui offerto per la successiva generazioni di artisti e architetti, nel primo Cinquecento
Colture organotipiche di epiteli cheratinizzati umani normali : modelli anatomici per lo studio della risposta iniziale a stimoli esogeni
No full textGiuliano da Sangallo e la storia dell'arte
No full textPrefazione al volume "Giuliano da Sangallo e le arti" con riflessioni metodologiche relative all'autore trattato
Morphological correlation between psoriasis vulgaris and guttate and a 3D in vitro psoriatic microenvironment
No full textPsoriasis is characterized by a great variety of clinical manifestations and they vary according to different phenotypes. Guttate or eruptive psoriasis (PG) (Saleh D et al 2018) shares genetic similarities with psoriasis vulgaris (PV) (Nestle FO 2009), the most represented clinical form. Cell types and molecules of both the innate and adaptive immunosystem are involved in the pathogenesis/progression of the disease, but several data concerning the early phase of the disease lack. A three dimensional model of organotypic cultures of normal human skin biopsies represents an useful approach for investigating the cellular mechanism(s) involved in the early epidermal response to proinflammatory psoriatic cytokines (Donetti et al, 2014; Donetti et al, 2017). The aim of this study was to compare cellular proliferation, the expression of Toll-like receptors (TLR) 7 and 9, and the innate immune response in lesional and perilesional skin of patients affected by PV or PG and in our model of organotypic culture after exposure to a cytokine mix (IL-17, IL-22, IL-23, and TNF-alpha) in a time-course study. Parallel ultrastructural analysis was performed. Keratinocyte proliferation in non lesional skin of both PG and PV was comparable, with PV lesional area as the most proliferative. In PG cell proliferation was exclusively localized in the basal layer. After mix incubation, a progressive decrease of cell proliferation was detected as an early response to proinflammatory stimulus. TLR9 was present in the granular layer of non lesional skin and mix samples and in the suprabasal layers of PV/PG lesional skin. TLR7 distribution was clearly different in each group, highlighting a specific response to the specific microenvironment.
In conclusion, these results prove that a psoriatic microenvironment is able to modify the expression of TLR7 and TLR9 in our model from human skin. These observations provide also new insights regarding the specific localisation of these two receptors and this could be an important detail for the many new small molecules targeted against TLRs for the therapy of chronic inflammatory disease, including psoriasis
Motivi di un viaggio
No full textSi dà conto del tema comune a numerosi saggi, di diversa ispirazione metodologica, raccolti in questo volume di studi in onore di Alessandro Nova
- …
