1,721,623 research outputs found

    Molecular genetic psychophysiology: A perspective on the Minnesota contribution

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    Progress in molecular genetic psychophysiology, on display in this special issue, shows that the affective and cognitive processes tagged by psychophysiological endophenotypes are highly polygenic. Identifying overlap in the genetic variants that influence these endophenotypes as well as behavioral traits can help us understand where in the brain, in which stage, and during what type of information processing these variants play a role in normal and abnormal behavior. The Minnesota Twin Family Study has demonstrated that the assessment of genetic markers and extensive psychophysiological experimentation can be done at a genetic epidemiological scale, that is, in thousands of subjects. A genome-wide association meta-analysis consortium consisting of psychophysiological research teams following the Minnesotan example is the obvious next step

    Supplement: Unidirectional and Bidirectional Causation between Smoking and Blood DNA Methylation: Evidence from Twin-based Mendelian Randomisation

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    This project contains the supplementary materials of the manuscript: Singh M., Dolan C.V., Lapato D.M., Hottenga J.-J., Pool R., Verhulst B., Boomsma D.I., Breeze C.E., de Geus E.J.C., Hemani G., Min J.L., Peterson R.E., Maes H.H.M., van Dongen J. & Neale M.C. (2025). Unidirectional and Bidirectional Causation between Smoking and Blood DNA Methylation: Evidence from Twin-based Mendelian Randomisation. European Journal of Epidemiology. https://doi.org/10.1007/s10654-024-01187-
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