1,721,189 research outputs found
The role of radiation therapy in locally advanced rectal cancer [In regard to primary surgery followed by selective chemoradiotherapy versus preoperative chemoradiotherapy followed by surgery for locally advanced rectal cancer: a randomized clinical trial]
No full textThe role of radiation therapy in locally advanced rectal cance
Docetaxel plus radiotherapy for head and neck cancer
No full textDocetaxel and radiotherapy in head and neck cance
FLASH radiotherapy in head and neck cancer: myth or reality?
No full textFlash RT in head and neck cance
Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: hypothesis coming from the subgroup analysis
No full textPembrolizumab in head and neck cancer
Harrington et al reported on the updated results of the phase III KEYNOTE-048 trial assessing pembrolizumab, an anti-PD-1 monoclonal antibody, with or without chemotherapy in recurrent/metastatic (RM) head and neck squamous cell carcinoma (HNSCC). A total of 882 recurrent/metastatic HNSCC patients were randomized 1:1:1 to pembrolizumab monotherapy (PM) (n = 301), pembrolizumab-chemotherapy (PC) (n = 281) or cetuximab-chemotherapy (n = 300).
we congratulate the study authors on this important contribution to the clinical management of such a highly complex disease. The subgroup analysis data suggests that there could be a population of patients achieving greater benefit from ICI in RM-HNSCC, thus giving a boost to clinical and translational research
Delineation of organs at risk in the head and neck region
No full textDelineation of organs at risk in the head and neck regio
Coronavirus disease (COVID-19): a machine learning bibliometric analysis
Full text linkBackground/Aim: To evaluate the research trends in coronavirus disease (COVID-19). Materials and Methods: A bibliometric analysis was performed using a machine learning bibliometric methodology. Information regarding publication outputs, countries, institutions, journals, keywords, funding and citation counts was retrieved from Scopus database. Results: A total of 1883 eligible papers were returned. An exponential increase in the COVID-19 publications occurred in the last months. As expected, China produced the majority of articles, followed by the United States of America, the United Kingdom and Italy. There is greater collaboration between highly contributing authors and institutions. The “BMJ” published the highest number of papers (n=129) and “The Lancet” had the most citations (n=1439). The most ubiquitous topic was COVID-19 clinical features. Conclusion: This bibliometric analysis presents the most influential references related to COVID-19 during this time and could be useful to improve understanding and management of COVID-19
Risk-reducing surgery in BRCA 1/2 mutation carries: a point of view
Full text linkThe work aspires to provide a reliable evaluation of the effect of risk-reducing surgery, both salpingoophorectomy (RRSO) and bilateral mastectomy (BRRM), to reduce long-term onset of ovarian cancer OC and/or BC in BRCA 1/2 mutation carries
IAP inhibitor plus chemoradiotherapy for the treatment of bulky anal canal carcinoma
Full text linkThe aim of this editorial is to focus on the urgent need to improve clinical outcomes in patients with bulky primary anal canal carcinoma
Impact of sphincter invasion on T stage definition in rectal cancer
No full textDear Editor: Uniform stage is the strongest predictor of survival for patients with rectal cancer. Accurate staging is paramount for appropriate patient management and clinical research comparison. Historically, tumor staging is based on local tumor characteristics (T), lymph nodes involvement (N), and presence of distant metastasis (M). In the seventh edition of the American Joint Committee on Cancer (AJCC) staging, T4 was subdivided into T4a (tumor penetrates to the surface of thevisceralperitoneum) andT4b(tumordirectlyinvadesoris adherent to other organs or structures) [1]. These changes were supported by SEER rectal cancer outcomes data that showed a 10 % improvement in 5-year overall survival in patients with T4a lesion compared with T4b [2]
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