4,422 research outputs found
Torque prediction using the flux-MMF diagram in AC, DC, and reluctance motors
No full textThis paper uses the flux-MMF diagram to compare and contrast the torque production mechanism in seven common types of electric motor. The flux-MMF diagram is a generalized version of the flux-linkage versus current (ψ-i) diagram for switched-reluctance motors. It is illustrated for switched-reluctance, synchronous-reluctance, induction, brushless AC, brushless DC, interior PM and commutator motors. The calculated flux-MMF diagrams for motors with the same electromagnetic volume, airgap, slotfill, and total copper loss are shown and are used to compare the low-speed torque and torque ripple performance. The motor designs used were reasonably optimized using a combination of commercially available motor CAD packages and finite-element analysis
A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium
No full textOBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease. This study tests whether common genetic variants with pleiotropic effects account for some of the correlated architecture among five metabolic phenotypes that define MetS. RESEARCH DESIGN AND METHODS Seven studies of the STAMPEED consortium, comprising 22,161 participants of European ancestry, underwent genome-wide association analyses of metabolic traits using a panel of ∼2.5 million imputed single nucleotide polymorphisms (SNPs). Phenotypes were defined by the National Cholesterol Education Program (NCEP) criteria for MetS in pairwise combinations. Individuals exceeding the NCEP thresholds for both traits of a pair were considered affected. RESULTS Twenty-nine common variants were associated with MetS or a pair of traits. Variants in the genes LPL, CETP, APOA5 (and its cluster), GCKR (and its cluster), LIPC, TRIB1, LOC100128354/MTNR1B, ABCB11, and LOC100129150 were further tested for their association with individual qualitative and quantitative traits. None of the 16 top SNPs (one per gene) associated simultaneously with more than two individual traits. Of them 11 variants showed nominal associations with MetS per se. The effects of 16 top SNPs on the quantitative traits were relatively small, together explaining from ∼9% of the variance in triglycerides, 5.8% of high-density lipoprotein cholesterol, 3.6% of fasting glucose, and 1.4% of systolic blood pressure. CONCLUSIONS Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants
Performance estimation of interior permanent-magnet brushless motors using the voltage-driven flux-MMF diagram
No full textThe flux-magnetomotive force (flux-MMF) diagram, or "energy conversion loop," is a powerful tool for computing the parameters of saturated interior permanent-magnet brushless motors, especially when the assumptions underlying classical dq theory are not valid, as is often the case in modern practice. Efficient finite-element computation of the flux-MMF diagram is possible when the motor current is known a priori, but in high-speed operation the current regulator can lose control of the current waveform and the computation becomes "voltage-driven" rather than "current-driven." This paper describes an efficient method for estimating the motor performance-average torque, inductances-by solving the voltage-driven problem. It presents experimental validation for a two-pole brushless interior permanent-magnet motor. The paper also discusses the general conditions under which this method is appropriate, and compares the method with alternative approaches
Phase diagram of turbulent Taylor-Couette flow
No full textWe will present the results of our recent numerical work on the nature of the phase diagram of turbulent Taylor-Couette (TC) flow, both with co- and counterrotating cylinder. The work can be seen as the extension of the famous experimental Andereck et al. phase diagram for Taylor-Couette flow just above the onset of instabilities, towards the ultimate turbulence regime, and now obtained numerically. In particular, we will understand when and why optimal transport of angular velocity from the inner to the outer cylinder is achieved and how this is connected to the angular velocity profile and the structures in the flow
The SH2B1 obesity locus and abnormal glucose homeostasis:lack of evidence for association from a meta-analysis in individuals of European ancestry
No full textBACKGROUND/AIMS: The development of type 2 diabetes (T2D) is influenced both by environmental and by genetic determinants. Obesity is an important risk factor for T2D, mostly mediated by obesity-related insulin resistance. Obesity and insulin resistance are also modulated by the genetic milieu; thus, genes affecting risk of obesity and insulin resistance might also modulate risk of T2D. Recently, 32 loci have been associated with body mass index (BMI) by genome-wide studies, including one locus on chromosome 16p11 containing the SH2B1 gene. Animal studies have suggested that SH2B1 is a physiological enhancer of the insulin receptor and humans with rare deletions or mutations at SH2B1 are obese with a disproportionately high insulin resistance. Thus, the role of SH2B1 in both obesity and insulin resistance makes it a strong candidate for T2D. However, published data on the role of SH2B1 variability on the risk for T2D are conflicting, ranging from no effect at all to a robust association.METHODS: The SH2B1 tag SNP rs4788102 (SNP, single nucleotide polymorphism) was genotyped in 6978 individuals from six studies for abnormal glucose homeostasis (AGH), including impaired fasting glucose, impaired glucose tolerance or T2D, from the GENetics of Type 2 Diabetes in Italy and the United States (GENIUS T2D) consortium. Data from these studies were then meta-analyzed, in a Bayesian fashion, with those from DIAGRAM+ (n = 47,117) and four other published studies (n = 39,448).RESULTS: Variability at the SH2B1 obesity locus was not associated with AGH either in the GENIUS consortium (overall odds ratio (OR) = 0.96; 0.89-1.04) or in the meta-analysis (OR = 1.01; 0.98-1.05).CONCLUSION: Our data exclude a role for the SH2B1 obesity locus in the modulation of AGH.</p
Domains of Digital Literacy [diagram]
No full textThis diagram illustrates three interconnected domains of digital literacy (procedural and technical, cognitive, and sociocultural). Please cite this diagram as: Smith, E. E., Kahlke, R. & Judd, T. (2018). Domains of digital literacy. [Diagram]. https://doi.org/10.6084/m9.figshare.11908425
This diagram was created for a paper presentation at ASCILITE 2018. The paper informing the diagram, including the full list of references, is available at: Smith, E. E., Kahlke, R. & Judd, T. (2018). From digital natives to digital literacy: Anchoring digital practices through learning design. In M. Campbell, J. Willems, C. Adachi, D. Blake, I. Doherty, S. Krishnan, S. Macfarlane, L. Ngo, M. O’Donnell, S. Palmer, L. Riddell, I. Story, H. Suri & J. Tai (Eds.), Open Oceans: Learning without borders. Proceedings ASCILITE 2018 Geelong (pp. 510-515). http://2018conference.ascilite.org/conference-proceedings/This research was supported by the Social Sciences and Humanities Research Council of Canada
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
No full textPhospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88x10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10x10(-57)). After a correction for multiple comparisons (P-value<2.2x10(-9)), we observed four novel loci significantly associated with phospholipids (PAQR9, AGPAT1, PKD2L1, PDXDC1) and two with sphingolipids (PLD2 and APOE) explaining up to 3.1% of the variance. Further analysis of the top findings with respect to within class molar proportions uncovered three additional loci for phospholipids (PNLIPRP2, PCDH20, and ABDH3) suggesting their involvement in either fatty acid elongation/saturation processes or fatty acid specific turnover mechanisms. Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ITGA9, AGPAT1, FADS1-2-3, APOA1, PCDH20, LIPC, PDXDC1, SGPP1, APOE, LASS4, and PLD2) to the sphingolipid pathways. In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed. In conclusion, our study identified nine novel phospho- and sphingolipid loci, substantially increasing our knowledge of the genetic basis for these traits
Flow diagram of the inclusion criteria of the 135,479 HIV-infected children aged 0–19 years enrolled in the IeDEA Global Cohort Consortium from 2004 to 2015.
No full textFlow diagram of the inclusion criteria of the 135,479 HIV-infected children aged 0–19 years enrolled in the IeDEA Global Cohort Consortium from 2004 to 2015.</p
Macroscopic Fundamental Diagram for Train Platforms
No full textThe macroscopic fundamental diagram (MFD) relates the flow, density and speed of an entire network. So far, the MFD has been mostly applied to cases where pedestrians and vehicles were aiming to reach their destinations as fast as possible. However, pedestrian facilities involve different behaviours. Especially in train stations, travellers spend more time waiting than walking. Moreover, complex passenger flows (i.e. flows in different directions moving to stairs and escalators distributed over the platform) may occur on the platform, due to passengers. In this paper we show that passenger flows on platforms can be described by an MFD.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and PlanningTransport and Plannin
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
No full textType 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR) = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.</p
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