3,318 research outputs found
Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium
No full textINTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes. PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change. RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m 2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m 2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively). CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
No full textGenome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer
WI told to embrace change
No full textNewspaper Article - 'WI told to embrace change' - By Mary MacArthur-Camrose bureau - June 19, 1998. Delegates at the Alberta Women's Institutes meeting in Camrose were told to change with the times.AWI CollectionWI told to embrace change
By Mary MacArthur
Camrose bureau
Marion Brown stood at the front of the convention
hall and asked the women if they could remember
when they were afraid to eat food
cooked in a microwave oven.
Then the Alberta Women's Institutes'
convener on agriculture education
asked how they feel today about
biotechnology and genetically altered
food.
Agriculture is changing, the world is
changing and Brown challenged the
women to find out as much as they can
about the changing world to help
them face the upcoming
changes to
theWI.
The Challenge of
Change was the
theme of the two-day
AWI convention
in Camrose.
Keynote speaker
Morris Flewwelling
said the women may
feel overwhelmed
with changes facing
their organization
established in 1909,
but change is nothing
new.
In the past 50
years homes have
gone from rotary
telephones to computers
and the in-
V ou have to
change the WI to
remain strong,
relevant and vital."
— MORRIS FLEWWELLING,
SPEAKER
WP photo by Mary MacArthur
DELEGATES AT THE ALBERTA WOMEN'S INSTITUTES MEETING IN
CAMROSE WERE TOLD TO CHANGE WITH THE TIMES.
ternet. Hospitals and libraries, once established by
Women's Institutes to help the community, are being
run by government- appointed boards and the rural
economy is tied to global happenings.
" The WI has been an engine on the
train in many areas of social change," said
Flewwelling, adding that the organization
must continue its community work.
" At no time in our history have we
needed people like you more."
With an aging membership and a
structure that hasn't changed much since
it was established, Flewwelling challenged
the women to adopt change within
their organization.
" You may have
to change the WI
in order to remain
strong, relevant
and vital. You may
have to change
your structure.
" You need an organization
that is
responsive, athletic
and loving."
President Doris
Northey of Red
Deer echoed Flew-welling's
remarks
that change is necessary.
" We will move
forward. We will
have regrets, but
we will move forward.
Recent Case Law on External Competences of the European Union: How Member States can embrace their own Treaty. EPIN Working Paper No. 43 / January 2017
No full textThe challenges facing Europe today cannot be addressed without putting into practice one of the main objectives pursued by member states when concluding the Treaty of Lisbon, argues the author of this paper; that objective being that the Union should be capable of acting as a strong and united player on the international scene, rather than as a more or less effective coordination platform for 28 international policies. Brexit and the new administration in Washington only reinforce this finding. To ensure that the Union can play this role, member states must, however, accept that the Union effectively exercises the competences that have been attributed to it.
This EPIN working paper offers a systematic analysis of the consequences that should be drawn from recent case law. Mostly, it seeks to identify possible avenues to allow legal disputes to be overcome, with a view to achieving the objectives that were pursued through the Treaty of Lisbon; in effect allowing member states to embrace their own Treaty. The author seeks to show that the conclusion of agreements by the Union alone (without ‘mixity’) neither leads to ‘uncontrolled power creep by Brussels’, nor to the disappearance of member states from the international scene
Height and body mass index as Modifiers of breast cancer risk in BRCA1/2 mutation carriers: A Mendelian randomization study
No full textBackground: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants.We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. Results: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P=1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P=.47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P=.007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P=.02). BMI was primarily associated with premenopausal breast cancer. Conclusion: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management
Intimacy. The embrace in the Argentine tango
No full textThe Argentine tango, a genre that originated from migrant music and dance traditions in the port districts of Buenos Aires and Montevideo in the late 19th century, has enjoyed a revival in the last two decades. The tango is listened to, learned, and danced around the world, at local milongas, marathons, and festivals gathering even as many as hundreds of dancers. This article presents the history of the tango and discusses its present popularity through the prism of intimacy that forms between two dancers connected in the close embrace that satisfies their deep emotional needs. The author also highlights the social and cultural dimension of the tango’s popularity driven by the currently common deficit of a non-sexual touch. Intimacy in the abrazo, the tango embrace, may appear when certain technical conditions are met by the dancers (relaxed muscles, open chest, proper floor work, breathing exercises). Referring to Richard Shusterman’s somaesthetics as the primary theoretical perspective, the author conducts a phenomenological analysis of the abrazo, trying to construct the ‘somaesthetics of the embrace’
The elusive embrace : desire and the riddle of identity /
No full text"Hailed for its searing emotional insights, and for the astonishing originality with which it weaves together personal history, cultural essay, and readings of classical texts by Sophocles, Ovid, Euripides, and Sappho, The Elusive Embrace is a profound exploration of the mysteries of identity. It is also a meditation in which the author uses his own divided life to investigate the "rich conflictedness of things," the double lives all of us lead. Daniel Mendelsohn recalls the deceptively quiet suburb where he grew up, torn between his mathematician father's pursuit of scientific truth and the exquisite lies spun by his Orthodox Jewish grandfather; the streets of manhattan's newest "gay ghetto," where "desire for love" competes with "love of desire;" and the quiet moonlit house where a close friend's small son teaches him the meaning of fatherhood. And, finally, in a neglected Jewish cemetery, the author uncovers a family secret that reveals the universal need for storytelling, for inventing myths of the self. The book that Hilton Als calls "equal to Whitman's 'Song of Myself, '" The Elusive Embrace marks a dazzling literary debut."--Geographies; Multiplicities; Paternities; Mythologies; Identities."Hailed for its searing emotional insights, and for the astonishing originality with which it weaves together personal history, cultural essay, and readings of classical texts by Sophocles, Ovid, Euripides, and Sappho, The Elusive Embrace is a profound exploration of the mysteries of identity. It is also a meditation in which the author uses his own divided life to investigate the "rich conflictedness of things," the double lives all of us lead. Daniel Mendelsohn recalls the deceptively quiet suburb where he grew up, torn between his mathematician father's pursuit of scientific truth and the exquisite lies spun by his Orthodox Jewish grandfather; the streets of manhattan's newest "gay ghetto," where "desire for love" competes with "love of desire;" and the quiet moonlit house where a close friend's small son teaches him the meaning of fatherhood. And, finally, in a neglected Jewish cemetery, the author uncovers a family secret that reveals the universal need for storytelling, for inventing myths of the self. The book that Hilton Als calls "equal to Whitman's 'Song of Myself, '" The Elusive Embrace marks a dazzling literary debut."--Rubin, Dere
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers
No full textBACKGROUND: Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS: We applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS) using 586 height-associated variants and a BMI genetic score (BMI-GS) using 93 BMI-associated variants. Associations were assessed using weighted Cox models. RESULTS: Observed height was not associated with ovarian cancer risk (hazard ratio [HR]: 1.07 per 10-cm increase in height, 95% confidence interval [CI]: 0.94-1.23). Height-GS showed similar results (HR = 1.02, 95% CI: 0.85-1.23). Higher BMI was significantly associated with increased risk in premenopausal women with HR = 1.25 (95% CI: 1.06-1.48) and HR = 1.59 (95% CI: 1.08-2.33) per 5-kg/m 2 increase in observed and genetically determined BMI, respectively. No association was found for postmenopausal women. Interaction between menopausal status and BMI was significant (P interaction < 0.05). CONCLUSION: Our observation of a positive association between BMI and ovarian cancer risk in premenopausal BRCA1/2 mutation carriers is consistent with findings in the general population
Toward a Cultural Heritage of Adaptation: A Plea to Embrace the Heritage of a Culture of Risk, Vulnerability and Adaptation
No full textWe need to tell a new story about urbanizing delta regions. Historically, large-scale ‘iconic’ hydraulic works and modern industrial ports have been celebrated as showing the power of humans to control and subject nature. The emphasis on this part of cultural heritage tends to bury the remains of engineering and urban development of the previous periods and to erase the ebb and flow of natural processes in the earlier landscape. Instead of emphasizing resistance against nature and victories over nature, we need to embrace mitigation, adaptation, and uncertainty. Many urbanized delta regions, including the Dutch delta, have a rich history of such approaches. We can learn from that history, from the successes as well as from the failures. This chapter is a plea to embrace the dynamic and evolutionary character of delta regions and the cultures of adaptation which have been developed over many centuries. It means that another policy concerning cultural heritage should be stimulated in urbanizing deltas, fostering a heritage with an adaptive approach, not as a complete departure from present ways of doing things, but as a new stage in a centuries-long tradition.Urban Desig
ISC/OSI Journal Authors Survey Report
No full textOn behalf of the Joint Information Systems Committee (JISC) and the Open Society Institute (OSI) a survey of journal authors has been carried out by Key Perspectives Ltd. The terms of reference were to poll a cohort of authors who had published on an open access basis and another cohort of authors who had published their work in conventional journals without making the article available on open access. The survey’s aims were to investigate the authors’ awareness of new open access possibilities, the ease of identification of and submission to open access outlets, their experiences of publishing their work in this way, their concerns about any implications open access publishing may have upon their careers, and the reasons why (or not) they chose to publish through an open access outlet
- …
