12 research outputs found
Investigation on Anti-Proliferation Properties of Porcupine Bezoar (Hystrix Brachyuran) Extracts Exposed on Hela Cells Lines Combined with Electroporation Technique
Full text linkElectroporation (EP) is a technique whereby the biophysical changes on the cells that induced external highintensity electrical field pulses in order to enhance applications in the medical field. It is a molecular biology technique in order to create pores through a cell wall membrane, boost the permeability of the cell membrane, and support chemicals, drugs or DNA to be imported into Hela cells. While by combining electroporation (EP) technique with porcupine bezoar (PB) extract might reduce the proliferation of HeLa cells because this compound extract has the ability of antiproliferation and also anti-angiogenesis properties for controlling cancer cell growth. This research concentrate on reviewing and analyses the basic concepts and methods of combining electroporation and porcupine bezoar (PB) extract as applied in cancer treatment application. The combination of this technique might be a new alternative for anti-cancer treatment. The combination of this technique might be a new way for anticancer treatment
Influence of artocarpus altilis fruit extract on cancer cell
Full text linkConventional chemopreventive agents causes adverse side effects in cancer patients. Thus, this study focuses on the effects of natural plant extract against cancer cell as a way to reduce or detrimental effects of orthodox drugs. The present study emphasizes on anti-cancer potentiality of Artocarpus altilis fruit extract against cervical cancer cell. Cervical cancer cell treated with methanol extract of artocarpus altilis fruit with the concentration varied from 10μg/ml, 20μg/ml, 30μg/ml, 40μg/ml and 50μg/ml. Treated and untreated (cells without treatment) cell proliferation and half maximal inhibitory concentration IC50 measured after 72 hours of incubation. Cells without treatment, 10μg/ml, 20μg/ml, 30μg/ml, 40μg/ml and 50 μg/ml of extract concentration showed 1.3, 0.98, 0.72, 0.65, 0.51, and 0.3 of cell proliferation factor accordingly with 40μg/ml of IC50 value. The result shows that artocarpus altilis is capable in opposing cervical cancer cell proliferation or growth as the proliferation factor decreases with the increasing dose of extract concentration which can be attributed to the presence of bioactive compound in Artocarpus altilis
Automated human cortical bone Haversian canal histomorphometric comparison system
No full textThis research presents comparison of histological parameters of cortical bones for Malaysian population. For this research 44 samples were collected from Department of Pathology, Faculty of Medicine Universiti Kebangsaan Malaysia. Sample preparation being one of the important aspects of this research, is described in detail. Six Haversian canal-based parameters were selected for the comparison. Sex and race comparisons were performed on the collected Malaysian samples. Race comparison was performed between the two Malaysian races (Chinese-Indian). The results obtained from sex comparison demonstrates difference in mean Haversian canal area (hcm). The hcm parameter in female samples were found to be significantly larger than male samples (P < .05). This research also presents an automated system which can be used as a platform to perform Haversian canal parameter comparison. The system is designed to automatically check normality of the parameters measurement data and select the relevant comparison test. It is divided into two main section. The first section provides race comparison platform while the second section is dedicated for sex comparison
Nanocomposite-Based Electrode Structures for EEG Signal Acquisition
No full textObjective: To fabricate a lightweight, breathable, comfortable, and able to contour to the curvilinear body shape, electrodes built on a flexible substrate are a significant growth in wearable health monitoring. This research aims to create a GNP/FE electrode-based EEG signal acquisition system that is both efficient and inexpensive. Methodology: Three distinct electrode concentrations were developed for EEG signal acquisition, three distinct electrode concentrations (1.5:1.5, 2:1, and 3:0). The high strength-to-weight ratio to form the tribofilm in the fabrication of the electrode will provide good efficiency. The EEG signal is first subjected to a wavelet transform, which serves as a preliminary analysis. The use of biopotential signals in wearable systems as biofeedback or control commands is expected to substantially impact point-of-care health monitoring systems, rehabilitation devices, human–computer/machine interfaces (HCI/HMI), and brain–computer interfaces (BCIs). The graphene oxide (GO), glycerol (GL), and polyvinyl alcohol (PVA) GO/GL/PVA plastic electrodes were measured and compared to that of a commercially available electrode using the biopic equipment. The GO/GL/PVA plastic electrode was able to detect EEG signals satisfactorily after being used for two months, demonstrating good conductivity and lower noise than the commercial electrode. The GO/GL/PVA nanocomposite mixture was put into the electrode mold as soon as it was ready and then rapidly chilled. Results: The quality of an acquired EEG signal could be measured in several ways including by its error percentage, correlation coefficient, and signal-to-noise ratio (SNR). The fabricated electrode yield detection ranged from 0.81 kPa−1 % to 34.90 kPa−1%. The performance was estimated up to the response of 54 ms. Linear heating at the rate of 40 °C per minute was implemented on the sample ranges from 0 °C to 240 °C. During the sample electrode testing in EEG signal analysis, it obtained low impedance with a good quality of signal acquisition when compared to a conventional wet type of electrode. Conclusions: A large database was frequently built from all of the simulated signals in MATLAB code. Through the experiment, all of the required data were collected, checked against all other signals, and proven that they were accurate representations of the intended database. Evidence suggests that graphene nanoplatelets (GNP) hematite (FE2O3) polyvinylidene fluoride (PVDF) GNP/FE2O3@PVDF electrodes with a 3:0 concentration yielded the best outcomes
Causes and alternative treatments of neurological conditions due to environmental toxins:An overview
No full textIt is fairly obvious that we live in a toxic world and our brains are poisoned continuously, and this constant low level of exposure over time is slowly damaging our neurons and brain cells. The worse news is that this harmful toxic environment is not going to stop anytime in the foreseeable future and environmental toxins are a leading cause of neurological illnesses. It is also well established that oxidative stress contributes to various diseases including diabetes, heart disease, inflammatory conditions, high blood pressure, and neurological diseases such as Alzheimer's and Parkinson's. It is therefore inevitable that exposure to such conditions including heavy metals, EMF radiation, bacteria and viruses will require a strong immune system to defeat such harmful toxins, and that almost 80 percent of the immune system is located in the gut. The main causes of neurological diseases are already known and the standard drug treatments (e.g., Aricept and Namenda for Alzheimer's) slow the progression of such terrible diseases, but they do not address the root cause of memory loss. Glutathione is known as body's master antioxidant being effective against oxidative stress and inflammation. Along with other natural antioxidants in the body, it works to defeat the harmful effects of free radicals which cause damage to cells and tissue leading to various health conditions. In this review, the main factors, including environmental toxins, causing neurological illnesses like Alzheimer's and Parkinson's, and natural ways of prevention and treatment protocols have been discussed. The proposed treatment protocol could be lifesaving and is supported by the extensively published literature. </p
