5,088 research outputs found
Letter from Nicholas Pitaro, New York State Associate Justice, to Geraldine Ferraro
No full textCongratulatory letter from Nicholas L. Pitaro, New York State Associate Justice, to Geraldine Ferraro. Includes standard response letter from Ferraro.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_new_york/1221/thumbnail.jp
«Il sale della satira è il condimento della commedia». Elements in the European Mock-Heroic Poem
No full textLuca Ferraro
L’articolo è incentrato sul rapporto tra eroicomico e satira. Gli autori passati in rassegna sono i principali del canone europeo: Tassoni, Boileau, Pope e Parini. L’obiettivo è stato quello di verificare quanto l’elemento satirico sia parte integrante del genere inventato da Tassoni. Nella seconda parte del testo si è cercato di dimostrare che la satira diventa la forma del comico predominante nei poemi eroicomici successivi alla Secchia rapita. Analizzandone in ordine cronologico le opere più rappresentative, si è voluto fare una riflessione sul genere e su come mutano gli elementi che lo caratterizzano nel corso dei suoi quasi due secoli di vita.
The focus of this paper is the relationship between mock-heroic and satire. The analysis will deal with the most important satirical and mock-heroic authors in Europe : Tassoni, Boileau, Pope and Parini. The purpose is to prove how the satirical element is an essential part of the genre invented by Tassoni. In the second part of the paper we will try to demonstrate that the satire becomes the main mode of the comic in mock-heroic poems after the Secchia rapita. By analyzing chronologically the most representative works, our article proposes a reflection about the genre and the evolution of its characteristics during almost two centuries
Near-infrared properties of 12 globular clusters towards the inner bulge of the Galaxy
No full textWe present near-infrared colour-magnitude diagrams and physical parameters for a sample of 12 galactic globular clusters located towards the inner bulge region. For each cluster we provide measurements of the reddening, distance and photometric metallicity and of the luminosity of the horizontal branch red clump and the red giant branch bump and tip. The sample discussed here, together with that presented in Valenti, Ferraro & Origlia (2007), represents the largest homogeneous catalogue of bulge globular clusters (comprising ~80 per cent of the entire bulge cluster population) ever studied
Prenatal THC exposure permanently disturbs kynurenic acid and glutamate levels and amplifies the responsivity to an acute kynurenine challenge in the rat prefrontal cortex
No full textThroughout the world, cannabis remains one of the most widely used illicit drugs during pregnancy (Porath-Waller, 2015). The main psychoactive component of marijuana (delta9-tetrahydrocannabinol, THC) passes through the placenta, and its use is correlated with early physiological effects in the offspring. Neurobehavioural and cognitive impairments have been reported in several longitudinal studies on children and adolescents prenatally exposed to marijuana (Calvigioni et al., 2014), and a link to psychiatric disorders has been proposed (Jutras-Aswad et al., 2009; Mathews et al., 2014). Prenatal exposure to cannabinoids induces cognitive deficits in rat offspring (Ferraro et al., 2009) and is associated with alterations in cortical/hippocampal glutamate and GABA levels (Antonelli et al., 2005, Beggiato et al., 2017). Interestingly, the deleterious effects of cannabinoids on cognitive functions are similar to those observed in adult rats prenatally exposed to (L)-kynurenine (KYN), which is the direct bioprecursor of kynurenic acid (KYNA), a neuroactive metabolite of tryptophan degradation (Pocivavsek et al., 2014). We therefore investigated whether alterations in KYNA levels in the rat brain might play a role in the long-term consequences of prenatal cannabinoid exposure. Pregnant Wistar rats were treated daily with THC [5 mg/kg or vehicle (sesame oil) by oral gavage] from gestational day (GD) 5 through GD 20. One adolescent [postnatal day 35-45] and one adult male rat per litter was then used to determine the extracellular levels of KYNA and glutamate before and after a challenge with KYN (5 mg/kg i.p.) by in vivo microdialysis in the medial prefrontal cortex (mPFC). Compared to vehicle-treated controls, extracellular basal KYNA levels were higher in adolescent and adult rats that had been prenatally treated with THC (p<0.01; p<0.05, respectively). These rats also had lower extracellular glutamate levels than respective controls (p<0.01; p<0.05, respectively). Following a challenge with KYN, extracellular KYNA levels increased in both adolescent groups (i.e. vehicle- and THC-treated; p<0.05) Interestingly, this effect was more pronounced in adult rats which had been prenatally exposed to THC. KYN also caused a trend towards a reduction in extracellular glutamate levels in vehicle-treated adolescent and adult rats. We propose that these permanent alterations in KYNA and glutamate signalling in the mPFC of prenatally THC-exposed rats could be relevant for cognitive dysfunction. Our results are also in line with the hypothesis that a “double-hit” may precipitate psychiatric disorders such as schizophrenia later in life
Ariosto, poeta della forma: dalle lezioni giovanili alla Storia della letteratura italiana di Francesco De Sanctis
No full textL’articolo si occupa dell’evoluzione del pensiero desanctisiano sul Rinascimento e sull’Orlando furioso attraverso tre tappe: Le lezioni giovanili napoletane, Le lezioni zurighesi e La storia della letteratura italiana. L’analisi è svolta individuando tre aspetti fondamentali: il rapporto epica-cavalleria, l’unità di trama, la forma. L’obiettivo è dimostrare come le opinioni di Francesco De Sanctis mutino in modo meno netto di quanto si possa pensare, in quanto alcuni punti fissi restano identici nel tempo. Quello che varia in modo sostanziale è il taglio prospettico attraverso il quale essi sono interpretati.Cet article aborde l’évolution de la pensée desanctisienne sur la Renaissance et le Roland furieux à travers trois étapes : ses premières leçons napolitaines, les Lezioni zurighesi et l’Histoire de la littérature italienne. L’analyse touche à trois aspects fondamentaux : la relation entre genre épique et genre chevaleresque, l’unité de trame, la forme. Notre propos est de démontrer que les opinions de Francesco De Sanctis évoluent moins drastiquement que ce que l’on pourrait penser, puisque certains points fixes restent identiques au fil du temps. Ce qui varie de façon substantielle, c’est la perspective à partir de laquelle ces points sont interprétés.This article focuses on the evolution of the thinking of De Sanctis about the Renaissance and the Orlando Furioso in three steps: the early Neapolitan lessons, the Lezioni Zurighesi and the History of Italian Literature. The analysis deals with three key aspects: the relationship between epic and chivalry, the unity of plot, and form. The purpose is to demonstrate how the opinions of De Sanctis change less radically than we may imagine, as some fixed points remain unchanged throughout time. What significantly changes is the perspective through which these points are interpreted
New species and additional records of Coenogonium (Ostropales : Coenogoniaceae) from southern South America
No full textFour new species of lichenized fungi from northern Argentina are described and illustrated: Coenogonium albomarginatum Michlig & L. I. Ferraro, C. brasiliense L. I. Ferraro & Michlig, C. flavovirens L. I. Ferraro & Michlig, and C. verrucosum Michlig & L. I. Ferraro. In addition, C. isidiatum (G. Thor & Vezda) Lücking et al., C. magdalenae Rivas Plata, Lücking & Lizano, C. persistens (Malme) Lücking et al., C. pusillum (Mont.) Lücking et al., and C. weberi (Vezda) Lücking et al. are recorded for the first time from South America. The known distribution of 24 species of this lichen genus is extended. A revision of the genus in Argentina and Paraguay is also presented.Fil: Ferraro, Lidia Itati. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); Argentina;Fil: Michlig, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Nordeste. Instituto de Botánica del Nordeste (i); Argentina
Evidence of morphological deformities in benthic foraminifera from holocene sediments of Sorrento Peninsula (South Tyrrhenian Sea)
No full textUn esempio di metodo critico in Tassoni: la lettura di Dante nel postillato alle "Terze rime" e nei "Pensieri"
No full textTHE PAPER FOCUSES ON THE WAY ALESSANDRO TASSONI READS AND ASSESSES THE COMMEDIA. IN THE FIRST PART IT EXAMINES HIS AUTOGRAPH NOTES ON THE EDITION OF DANTE’S TERZE RIME HELD IN THE BIBLIOTECA APOSTOLICA VATICANA (ALDINE III 8), WHICH WERE ONLY PARTIALLY EDITED SO FAR. THE FOLLOWING PART OF THE PAPER OFFERS A WIDER ARGUMENTATION ON THE LECTURA DANTIS OF THE EMILIAN WRITER, INVOLVING ALSO HIS OTHER WORKS, AND FOCUSING ON THE PECULIAR, AND OFTEN ECCENTRIC FEATURES OF THE NOTES. THE APPENDIX OFFERS THE WHOLE EDITION OF HIS NOTES ON THE TERZE RIME
CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation
No full textBackground: Naive T lymphocytes recirculate through the body, traveling from secondary lymphoid organs through tissues and via lymphatic vessels and peripheral blood into other secondary lymphoid organs and into the bone marrow. In these tissues, lymphocytes are exposed to the chemokine CXCL12 which is abundantly produced in bone marrow and in lymph nodes by stromal cells. CXCL12 is known to drive lymphocytes chemotaxis and, in cells types such as stem cells, an antiapopototic effect has been described.
Methods: Here we analyzed the effect of CXCL12 exposure on naive CD4+ T lymphocytes purified from peripheral blood by immunomagnetic negative isolation and cultured in a nutrient poor medium. We also studied, mainly by western blot analysis, the signaling pathways involved in CXCL12 action on naive CD4+ T lymphocytes.
Results: We found that CXCL12-exposed cells survived longer than untreated ones and this prolonged lifespan was specific for resting naive lymphocytes, while in vitro activated lymphoblasts died rapidly despite CXCL12 treatment. We demonstrated that the increased percentage of living cells observed upon CXCL12 administration was not due to induction of proliferation but to a prosurvival effect of this chemokine. Moreover, our data suggest that this prosurvival effect on naive CD4+ T lymphocytes might likely be mediated by PKA-dependent CREB activation and consequent increased expression of the antiapoptotic factors Bcl2 and BclXl.
Conclusions: This newly reported activity of CXCL12 might contribute to the maintenance of the naive T lymphocytes pool in vivo, which is needed to ensure a proper immune response to new antigens. (C) 2016 Elsevier Ireland Ltd. All rights reserved
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