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Microsurgical epididymal sperm aspiration and in vitro fertilization in patients with vas deferens agenesis [MESA (MICROSURGICAL EPIDIDYMAL SPERM ASPIRATION) E FERTILIZZAZIONE IN VITRO (IVF) IN PAZIENTI CON AGENESIA DEI DEFERENTI]
Evoluzione a lungo termine dei parametri clinici ed urodinamici in pazienti con IPB ostruttiva trattati con alpha litici
Patients with bladder outlet obstruction who refuse treatment show no clinical and urodynamic change after long-term follow-up
Objective: To evaluate in patients with mild bladder outlet obstruction (BOO) who refused the proposed treatment and were on watchful waiting (WW), the symptomatic and urodynamic changes after 1-5 years of follow-up. Methods: 102 patients with lower urinary tract symptoms (LUTS) and BOO (Schafer class: 2-6, median 3) were clinically and urodinamically re-evaluated after 1-5 years of follow-up. Of these, 82 were submitted to medical (alfuzosin or finasteride) or surgical treatment (prostatectomy or TUIP) and 20, who refused the proposed treatment, were on WW. A retrospective study was made on these 20 patients who underwent a second International Prostatic Symptom Score and pressure-low evaluation after 1-5 years (median: 22 months) of watchful waiting. Wilcoxon matched-pairs signed-ranks test and Kruskal Wallis as appropriate were used for statistical analysis. Results: In the group of patients who refused the proposed treatment, no statistically significant differences between the two evaluations were observed for any of the parameters investigated: International Prostatic Symptom Score (15.1±6.8; 14.7±7.5); maximum flow (11.5±4.2; 12.1±4.3); residual urine (90.2±154.5; 113.3±158.4); Schäfer class (2.9±0.9; 2.8±1.2); Urethral Resistance Algorithm (37.1±14.4; 37.3±16.3); Projected Isometric Pressure (113.7±26.5; 112.7±21.8). Conclusions: Patients with mild BOO may remain clinically and urodynamically stable for a long time
Ruolo delle ricostruzioni microchirurgiche delle vie seminali in era ICSI. Rivista italiana di video urologia. N° 2, Eds TREESSE
The role of microsurgical vasoepididymostomy in the ICSI era
Despite the recent success and diffusion of the techniques of sperm retrieval (MESA,TESE) for ICSI (IntraCytoplasmic Sperm Injection), microsurgical reconstruction of the seminal tract, when possible, should still be considered as the first choice treatment in epididymal obstructions, particularly m younger patients who wish to have more than one child Even in the case of the partial success of the procedure, i.e when only a few motile sperms appear in the ejaculate, it will be possible to use them for ICSI without a sperm retrieval operation. Vaso-epididimostomy can also be simultaneously associated with ICSI, employing fresh sperm aspirated from the tubule during the procedure or freezing the aspirated sperm for subsequent ICSI cycles. In the video-tape the technique of side to end double layer vaso-epididymostomy described by Thomas is illustrated. In our experience this technique is the most adequate and the easiest to accomplish for obstructions at any level of the epididymis (cauda, corpus, caput). After testing the patency of the distal part of the vas, a small opening is made on the albuginea of the epididymis A dilated tubule is incised and the fluid aspirated and examined under the microscope If motile sperm is found, a side to end anastomosis is performed. The inner layer between the mucosa of the vas and the epididymal tubule is sutured first, with five 10-0 nylon stitches. The outer layer between the muscularis of the vas and the albuginea of the epididymis is then sutured with eightten 9-0 nylon stitches. Two cases with obstruction respectively on the epididymal caput and cauda are shown in the video. In conclusion, although the success rate of ICSI in obstructive azoospermia is good, we still believe that an attempt at reconstruction for natural fertilization is to be recommended
The role of cremasteric reflux in the pathogenesis of varicocele: clinical implications of a new venographic approach.
Epididymal and testicular sperm retrievel (MESA-TESE) for ICSI in obstructive and secretory azoospermia
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