102,683 research outputs found
Engineering of human bone with Plexur MTM in acetabular roof reconstruction after curettage of a giant aggressive aneurismal bone cyst of the left emypelvis.
No full textA cyanoacrylate and silastic patch to reduce the risk of opening of the tumor: Technical note
No full textBACKGROUND: Wide surgery is the main factor influencing survival in muscular skeletal tumor. Sometimes the margin can be very thin and the contamination risk can be very high because of manipulation of the mass.
MATERIALS AND METHODS: A patch of cyanoacrylate and a silastic mesh are applied on tumor surface. In order to demonstrate the tumor sealing an histologic exam was performed.
DISCUSSION: The application of protective patch can decrease the risk of accidental tumor rupture and neoplastic cells spreading
Cutaneous cyanoacrylate glue and silastic patch to reduce the risk of tumor wide spreading after incisional biopsy.
No full textComfort Perception Analysis of Human Models Interfacing with Novel Biped-Wheeled-Exoskeletons
No full textThis paper presents a comfort perception analysis of human models interfacing with a novel biped-wheeled-exoskeleton. Usually, many attentions are given to the exoskeleton machine design but, in many cases, without considering the human comfort point of view. This paper merges the conceptual design of the novel biped-wheeled-exoskeleton machine, here proposed in a first time, with the analysis of the comfort perception of human models. The simulation of the human muscular activation is performed using the OpenSim software and the comfort analyses are done thanks to the literature review. Results underline how the comfort perception analysis of a human model with the same constraints of a wearable machine, may optimize the design process of a comfortable wearable hardware by the user. Novel comfortable joints range of motions of a human model, wearing biped-wheeled-exoskeletons, are also the results of this research work
Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases
No full textBackground: The mainstay treatment of primary malignant bone tumors is wide surgery in the spine. Unfortunately, most cases undergo the first approach in a nonspecialized center; this often means adopting an inappropriate approach with contamination, which consistently decreases the effectiveness of a second surgery. The aim of the present paper is to evaluate recurrence and survival rates after en-bloc resection.
Methods: All patients underwent wide resection by the senior author from January 1997 to December 2013 after the first inappropriate approach was reviewed. Fifty-six patients were included in the present evaluation. Epidemiologic and clinical characteristics, surgeries, early and late complications, and survival rate were reported.
Results: The margin obtained was wide, marginal, and intralesional in 9, 28, and 19 cases, respectively. The complication rates were 55.4% and 44.6% for early and late complications, respectively. Most (73.2%) of the patients had complications. The survival rate is 82.1% at 1 year and then decreases 10% each year until 42.1% at 5 years from surgeries. No statistically significant correlation was found between margin and local recurrence and survival.
Conclusion: In our series, the first inappropriate approach had already compromised patient prognosis, so in case of suspicious primary spine tumor, the patient had to be referred to a specialized center. The margin obtained during salvage surgery does not appear to influence recurrence and survival, probably because it is already compromised by the first surgery. More prospective studies are necessary to confirm our data and verify the impact of the margin obtained during salvage surgery on patients' survival
Chemotherapeutically induced cutaneous tubercolosis after BCG injection in a patient with pelvic osteosarcoma
No full textAbstract Background: Tuberculosis (TB) is a serious infection afflicting a multitude of people worldwide. Recently, its prevalence has increased. The incidence of skin involvement generally is low. Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that typically is administered as a vaccine to stimulate the immune system when treating some early neoplasms or to guard against tuberculosis. Methods: Case report and literature review. Case Report: The authors describe a young man with osteosarcoma of the left hemipelvis who received intradermal BCG injection for immune stimulation prior to surgery. In the course of neoadjuvant chemotherapy, he developed cutaneous tuberculosis. Conclusion: It is our opinion that BCG injection should be avoided in all patients requiring surgery, especially in oncologic patients, where the immunodeficiency brought on by chemotherapy predisposes to active opportunistic infection
Epithelioid hemangioendothelioma of the spine: results at seven years of average follow-up in a series of 10 cases surgically treated and a review of literature
No full textPurpose
To review a series of ten cases with epithelioid hemangioendothelioma of the spine, that have undergone surgery to describe clinical presentation, results and complications associated with surgical treatment; a review of literature reporting the main characteristics of the cases already published has been reported.
Methods
A review of patients affected by epithelioid hemangioendothelioma surgically treated by the senior author from 1995 to 2012 was carried out. Ten cases were identified and clinical and radiological characteristics, therapy, complications and survival were valued.
Results
Wide margin was achieved in two out of ten cases, marginal margin in seven and intralesional margin in one case. Average intraoperative blood loss was about 2,800 ml. Reported complications were one case of cord injury, one of dural tear, two cases of massive blood loss, a case of reconstruction failure, a wound dehiscence with deep infection, a pneumonia episode and a deep vein thrombosis with pulmonary embolism. Average follow-up was 84.4 months. Two local recurrences, after 32 and 37 months and two deaths for metastasis, after 14 and 36 months, were reported. Although several chemotherapy protocols are available for the treatment of EH of soft tissue, they are not relevant for the bone.
Conclusions
Wide surgery is probably associated with a better prognosis. Indeed most deaths and local recurrences reported in literature happened after intralesional surgery or chemotherapy/RT alone. The presenting study suggests that the best approach to achieve long-term local control and a major survival could be wide surgery, nevertheless more cases series are necessary to verify survival rate
The formation history of the Galactic bulge
No full textThe distributions of the stellar metallicities of K giant stars in several fields of the Galactic bulge, taken from the literature and probing projected Galactocentric distances of similar to500 pc to similar to3 kpc, are compared with a simple model of star formation and chemical evolution. Our model assumes a Schmidt law of star formation and is described by only a few parameters that control the infall and outflow of gas and the star formation efficiency. Exploring a large volume of parameter space, we find that very short infall time-scales are needed (less than or similar to0.5 Gyr), with durations of infall and star formation greater than 1 Gyr being ruled out at the 90 per cent confidence level. The metallicity distributions are compatible with an important amount of gas and metals being ejected in outflows, although a detailed quantification of the ejected gas fraction is strongly dependent on a precise determination of the absolute stellar metallicities. We find a systematic difference between the samples of Ibata & Gilmore, at projected distances of 1-3 kpc, and the sample in Baade's window (Sadler et al.). This could be caused either by a true metallicity gradient in the bulge or by a systematic offset in the calibration of [Fe/H] between these two samples. This offset does not play an important role in the estimate of infall and formation time-scales, which are mostly dependent on the width of the distributions. The recent bulge data from Zoccali et al. are also analysed, and the subsample with subsolar metallicities still rules out infall time-scales greater than or similar to1 Gyr at the 90 per cent confidence level. Hence, the short time-scales we derive based on the observed distribution of metallicities are robust and should be taken as stringent constraints on bulge formation models
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