1,721,483 research outputs found

    Esercizio fisico nei pazienti in trattamento dialitico: mortalità e performance

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    Progetto inserito nel Programma Strategico del Ministero della Salute (Area tematica: 5. Malattie dell’apparato urinario e dialisi) approvato nell’ambito del Programma per la Ricerca Sanitaria 2006: attività di ricerca finalizzata. RESPONSABILE SCIENTIFICO DEL PROGETTO: Zoccali C; RESPONSABILE SCIENTIFICO UNITÀ OPERATIVA TRAINING: Manfredini F; Obiettivo principale: valutare se un intervento originale basato su un programma di esercizio a bassa intensità prescritto nel Centro Dialisi e svolto a domicilio nei giorni di non dialisi rappresenti un modello esente da rischi per il paziente ed in grado di modificare significativamente la capacità funzionale e la Qualità della Vita dei pazienti in dialisi rispetto a un gruppo di controllo. Obiettivo secondario è valutare se nel periodo di osservazione (36 mesi) il rischio di mortalità totale e per cause cardiovascolari, di eventi CV non fatali e la sopravvivenza dell’accesso vascolare, risulti significativamente diverso in un gruppo di pazienti in dialisi sottoposti ad esercizio rispetto a un gruppo di controllo

    Arthroscopic patterns of the poster-medial aspect of the knee joint: classification of the gastrocnemius-semimembranosus gateway and its relationship with Baker's cyst

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    Background The gastrocnemius-semimembranosus bursa may communicate with the knee joint. The arthroscopic anatomy of the posteromedial aspect varies depending on the angle of the oblique popliteal ligament, the level at which it crosses the medial gastrocnemius tendon, and its relationship with the capsular joint and synovia. The aim of this paper is to identify possible patterns, and to evaluate their characteristics and their relationship with Baker’s cyst. Methods data archived from 185 consecutive arthroscopies were evaluated; an anatomic description and classification was carried out; the percentages of association with BC and the associated pathologies were reported. Results The different anatomies were classified into six groups based on the relationship above the medial gastrocnemius tendon, the capsular joint and synovia. The prevalence of Baker’s cyst was 28.3%. The main associated intra-articular pathological condition was the contemporary presence of a meniscal tear and chondropathy. Conclusion Exploration of the posterior aspect of the knee must be performed routinely. Knowing the possible anatomy patterns of the posteromedial arthroscopic aspect of the knee joint could help to identify the cyst and its gateway, thus facilitating its treatment

    Age, stage and biomarkers for the definition of CKD: a construction in progress.

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    The international recommendations of the Kidney Disease: Improving Global Outcomes (KDIGO) to define chronic kidney disease (CKD) and classify patients in CKD stages are discussed in an opinion paper published in this issue of the journal. In this counterpoint, we will review some questions and criticisms raised by the authors to provide further contribution on the issue. In particular, we would like to discuss the age issue in the definition of CKD, the validity of the KDIGO staging, the validity of creatinine-based equations for the estimation of the glomerular filtration rate (GFR), as well as the clinical value of cystatin C and the epidemiological rather than clinical nature of the arguments proposed to justify recommendations in the KDIGO guidelines

    Salvage revision surgery after inappropriate approach for primary spine tumors: long term follow-up in 56 cases

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    Background: The mainstay treatment of primary malignant bone tumors is wide surgery in the spine. Unfortunately, most cases undergo the first approach in a nonspecialized center; this often means adopting an inappropriate approach with contamination, which consistently decreases the effectiveness of a second surgery. The aim of the present paper is to evaluate recurrence and survival rates after en-bloc resection. Methods: All patients underwent wide resection by the senior author from January 1997 to December 2013 after the first inappropriate approach was reviewed. Fifty-six patients were included in the present evaluation. Epidemiologic and clinical characteristics, surgeries, early and late complications, and survival rate were reported. Results: The margin obtained was wide, marginal, and intralesional in 9, 28, and 19 cases, respectively. The complication rates were 55.4% and 44.6% for early and late complications, respectively. Most (73.2%) of the patients had complications. The survival rate is 82.1% at 1 year and then decreases 10% each year until 42.1% at 5 years from surgeries. No statistically significant correlation was found between margin and local recurrence and survival. Conclusion: In our series, the first inappropriate approach had already compromised patient prognosis, so in case of suspicious primary spine tumor, the patient had to be referred to a specialized center. The margin obtained during salvage surgery does not appear to influence recurrence and survival, probably because it is already compromised by the first surgery. More prospective studies are necessary to confirm our data and verify the impact of the margin obtained during salvage surgery on patients' survival
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