754 research outputs found
FIGURE 1. Liparis casseabria Q. Liu & X.F in Liparis casseabria, (Malaxideae: Orchidaceae) a new species from Chin State, Myanmar
No full textFIGURE 1. Liparis casseabria Q. Liu & X.F Wu, sp. nov. A. Habitat (Dipterocarp-forest); B. Plant; C. Inflorescence; D. Floral bract; E. Subterranean tuber; F. Lateral view of flower; G. Front view of flower; H. Ovary and column; I. Sepals and petals; J. Lateral view of labellum; K. Front view of labellum; L. Anther cap; M. PollinariumPublished as part of Wang, Yu-Qian, Wu, Xun-Feng, Li, Jin-Long, Zhou, Shi-Shun, Li, Ren, Liu, Qiang & Li, Lin, 2022, Liparis casseabria, (Malaxideae: Orchidaceae) a new species from Chin State, Myanmar, pp. 109-114 in Phytotaxa 575 (1) on page 111, DOI: 10.11646/phytotaxa.575.1.9, http://zenodo.org/record/740336
Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors
No full textAbstract not availableC.S. Ruan, F.H. Zhou, Z.Y. He, S.F. Wang, C.R. Yang, Y.J. Shen, Y. Guo, H.B. Zhao, L. Chen, D. Liu, J. Liu, B.T. Baune, Z.C. Xiao, X.F. Zho
High-resolution evidence from southern China of an early Holocene optimum and a mid-Holocene dry event during the past 18,000 years
No full textDifferent patterns of changes in the Asian summer and winter monsoons on the eastern Tibetan Plateau during the Holocene
No full text Previous sedimentological studies on peat sequences from the eastern Tibetan Plateau showed that there have been eolian dust inputs to the wetlands on the eastern Tibetan Plateau, thereby providing an opportunity to reconstruct the history of the Asian winter monsoon at a higher temporal resolution. Here the dust flux and the content of trace metallic elements (Ti, Ni, and V) in a peat sequence from the Hongyuan Swamp (32°46.7′N, 102°31.0′E) are used to reconstruct variations in the intensity of the Asian winter monsoon during the Holocene. This record, when compared with the summer monsoon proxy, can help elucidate the phase relationship between these two systems. Our proxy-based reconstructions show different patterns of changes in the Asian winter and summer monsoons before and after 5.5 cal. ka BP. Generally, the two monsoons varied reciprocally before 5.5 cal. ka BP; however, after 5.5 cal. ka BP, these two systems exhibit synchronous changes. Moreover, both the frequency and amplitude of the variations in these two monsoons are different before and after 5.5 cal. ka BP. The rate of changes in the solar insolation during the Holocene matches well with these monsoon records, implying that the mid-Holocene climate transition may have resulted from orbital forcing
Peripheral proBDNF delivered by an AAV vector to the muscle triggers depression-like behaviours in mice
No full textMajor depression is a leading cause of morbidity and disease burden in modern society. Current drug treatment is only effective in a fraction of patients as underlying mechanisms of depression are not fully understood. ProBDNF, a precursor of brain-derived neurotrophic factor (BDNF), and its receptor p75(NTR) are highly upregulated in patients with major depression and in animal models of depression induced by chronic stress. Here, we hypothesise that proBDNF may be a pathogenic factor triggering depression. C57BL/6 mice were injected in the bilateral gluteus maximus muscle with AAV-proBDNF or AAV-EGFP. Four weeks after the injection, AAV-proBDNF injected animals developed depression-like behaviours, which were evident for 4-8 weeks and then returned to the control level after 12 weeks. In the second experiment, mice were divided into three groups; one group was treated with sheep anti-proBDNF antibody after AAV-proBDNF injection whereas the other two groups received PBS injection after the AAV-proBDNF or AAV-EGFP delivery. The group that was injected with AAV-proBDNF showed a time-dependent increase in immobility time in the tail suspension test and forced swim test, reduced sucrose consumption and decreased grooming time after sucrose spraying. Treatment with sheep anti-proBDNF antibody alleviated the depressive-like symptoms. Peripheral AAV-proBDNF delivery also resulted in a reduction of density and length of dendritic spines in the dentate gyrus and amygdala. Thus, we conclude that peripheral proBDNF is a primary pathogenic factor triggering depression-like behavioural changes in mice likely by reducing dendritic spine plasticity.L.Y. Lin, S. Kelliny, L.C. Liu, M. Al-Hawwas, X.F. Zhou, L. Bobrovskay
Data assimilation in air pollution modelling
No full textElectrical Engineering, Mathematics and Computer Scienc
Foraging activity is reduced in a mouse model of depression
No full textDepression interferes with the human ability to make decisions. Multiple criteria have been adopted for the diagnosis of depression in humans, but no clear indicators are available in animal models to reflect the depressive mood, involving higher cognitive functions. The act of foraging is a species-specific behaviour which is believed to involve the decision-making and higher cognitive functions. We previously established a method to detect the foraging behaviour of rodents, in which our results demonstrated that NMDA and dopamine receptors were involved. Conversely, increased NMDA receptors and reduced dopamine have been reported in depression model rodents. However, we hypothesise that foraging activities may also be impaired in depression. To test the theory, we successfully established a mouse model of depression using the chronic unpredictable mild stress (CUMS) paradigm. Most interestingly, the food foraging activity of mice after CUMS was significantly reduced. In addition, the treatment of anti-depressant fluoxetine reversed most depressive symptoms and reduced glial fibrillary associated protein (GFAP) expression in the hippocampus, but was less effective in the reduction of foraging activities. However, clozapine reversed all symptoms of CUMS-exposed mice including reduction of GFAP expression in the hippocampus and impaired foraging activity. Our findings of GFAP expression as a marker to validate the CUMS protocol provide further validation of our hypothesis, that the reduced food foraging is probably a new behavioural finding of depression in which the serotoninergic system could not be singly involved. Our study suggests that NMDA receptors, serotoninergic and dopaminergic systems are differentially involved in these food foraging behaviours. Our data suggest that the foraging test in rodents can be a useful tool to assess the ability of decision-making in depression.C.R. Yang, Z.G. Zhang, Y.Y. Bai, H. Fiona Zhou, L. Zhou, C.S. Ruan, F. Li, C.Q. Li, H.Y. Zheng, L.J. Shen, X.F. Zho
Compositions of aliphatic des-A-triterpenes in the Hani peat deposit, Northeast China and its biological significance
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