376 research outputs found
Codes for theoretical calculation of group-induced subharmonics using near-resonant solutions
No full text% This is the codes for comparison of different solutions of group-forced infragravity waves based
% on the A-4 case of the experiment of Noorloos 2003. It is used to generate figure 6 in a manuscript to be published
%
% Usage:
% change to this folder and run main_compareNL03.m
%
% Author: Zhiling Liao @Heriot-watt Univ
% Date: 2022-12-18
% Email: [email protected]
sj-docx-1-cll-10.1177_09636897221139734 – Supplemental material for Therapeutic Efficacy of Human Mesenchymal Stem Cells With Different Delivery Route and Dosages in Rat Models of Spinal Cord Injury
No full textSupplemental material, sj-docx-1-cll-10.1177_09636897221139734 for Therapeutic Efficacy of Human Mesenchymal Stem Cells With Different Delivery Route and Dosages in Rat Models of Spinal Cord Injury by Guangyang Liu, Zhiling Zhao, Herui Wang, Chunhua Hao, Weiting Wang, Chenliang Zhang, Tiehua Wang, Xin Li, Jingjing Xi, Shaoyun Li, Haomiao Long, Yi Mi, Li Miao, Yaoyao Chen, Liqiang Xu, Libo Zheng, Hao Wang, Ning Ding, Fengmei Zhu, Qinggang Ge and Yongjun Liu in Cell Transplantation</p
Characterizing Electron Flow through Catechol-Graphene Composite Hydrogels
No full textElectronic materials that allow the controlled flow of electrons in aqueous media are required for emerging applications that require biocompatibility, safety, and/or sustainability. Here, a composite hydrogel film composed of graphene and catechol is electrofabricated, and that this composite offers synergistic properties is reported. Graphene confers metal-like conductivity and enables charge-storage through an electrical double layer mechanism. Catechol confers redox-activity and enables charge-storage through a redox mechanism. Importantly, there are two functional populations of catechols: conducting-catechols (presumably in intimate contact with graphene) allow direct electron-transfer; and non-conducting-catechols (presumably physically separated from graphene) require diffusible mediators to enable electron-transfer. Using a variety of spectroelectrochemical measurements, that the capacity of the composite for charge-storage increases in proportion to the extent by which the catechol-groups can undergo redox-state switching is demonstrated. To illustrate the broad relevance of this work, how the redox-state switching can be related to both the charge storage of energy materials and the memory of molecular electronic materials is discussed. The authors believe this work is significant because it demonstrates that: conducting and redox-active components enable distinctly different mechanisms for charge-storage and electron-transfer; these components act synergistically; and mediators provide unique opportunities to extend the capabilities of electronic materials
regreen/EMBD_public: Published version of the code
No full text<p>Code associated with:</p>
<p>Automated Profiling of Gene Function During Embryonic Development</p>
<p>Rebecca A. Green, Renat N. Khaliullin, Zhiling Zhao, Stacy. D. Ochoa, Jeffrey M. Hendel, Tiffany-Lynn Chow, HongKee Moon, Ronald J. Biggs, Arshad Desai and Karen Oegema</p>
<p>Submitted for publication 2023</p>
“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation
No full textThe loss in age-related immunological markers, known as immunosenescence, is caused by a combination of factors, one of which is inflammaging. Inflammaging is associated with the continuous basal generation of proinflammatory cytokines. Studies have demonstrated that inflammaging reduces the effectiveness of vaccines. Strategies aimed at modifying baseline inflammation are being developed to improve vaccination responses in older adults. Dendritic cells have attracted attention as an age-specific target because of their significance in immunization as antigen presenting cells that stimulate T lymphocytes.This article is published as Ananya, Ananya, Kaitlyn G. Holden, Zhiling Gu, Dan Nettleton, Surya K. Mallapragada, Michael J. Wannemuehler, Marian L. Kohut, and Balaji Narasimhan. “Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation. Immunity & Ageing 20, no. 1 (2023): 1-16.
DOI: 10.1186/s12979-023-00332-0.
Copyright 2023 The Author(s).
Attribution 4.0 International (CC BY 4.0).
Posted with permission
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Roles of mitosis and planar cell polarity pathway play in early amniote midline patterning
No full textMidline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline patterning in non-amniotes can occur without cell proliferation, in part by Planar Cell Polarity (PCP) signaling. On the contrary, both cell proliferation and PCP signaling are required in amniote for patterning early midline structure, the primitive streak (PS). Yet, their role in post PS-extension stages remains rudimental. Here, we systematically examined and defined their roles for midline patterning in amniotes using early chicken embryogenesis as a model system. Cell proliferation was indispensable for PS extension. In contrast, at the post PS-extension stages, notochord (NC) extension and Hensen’s node (HN)/PS regression persisted under mitotic arrest, although the embryo became shorter. Gene expression analysis revealed that midline identities were maintained while laterality was lost upon mitotic arrest. Further, while the majority of PCP core components were undetectable in the NC-HN-PS area at post PS-extension stages, Prickle-1 was robustly detected. However, morpholino knockdown of Prickle-1 showed little influence on midline patterning but suppressed embryonic growth. Lastly, associated with mitotic arrest-induced embryonic size reduction, midline tissues were consistent of cells with hypertrophy. At least two mitosis sensitivity phases are present from pre PS-formation to post PS-extension stages, including PS extension that requires mitosis and midline patterning that persists under mitotic arrest at post PS-extension stages. While PCP is indispensable for PS extension, the role of PCP for amniote midline patterning at post PS-extension stages remains to be explored
Roles of mitosis and planar cell polarity pathway play in early amniote midline patterning
No full textRoles of mitosis and planar cell polarity pathway play in early amniote midline patterning
No full textIntranasal exposure to ZnO nanoparticles induces alterations in cholinergic neurotransmission in rat brain
No full textThe neurotoxicity of inhaled ZnO nanoparticles (NPs) and the underlying mechanisms remain largely unknown. In this study, ZnO NPs (30 ± 6 nm) were intranasally instilled to rats via a single dose (13 mg Zn/kg BW), with ZnSO4 as the ionic control, and analysis 7-days post exposure. The hippocampus was found to be the main target for Zn accumulation for both ZnO NPs and ZnSO4. Synchrotron radiation based X-ray absorption fine structure (XAFS) analysis showed that no particulate ZnO was found, suggesting the occurrence of dissolution and transformation of ZnO NPs. Multi-omics analysis, including transcriptomics, proteomics and metabolomics, demonstrated that cholinergic neurotransmission was the main biological process affected following both treatments. The release of the key neurotransmitter acetylcholine (ACh) was increased by enhanced ACh synthesis, upregulation of vesicular ACh transporter, and suppression of the activity of ACh hydrolysis enzyme (AChE), either by direct Zn-AChE interaction or a transcriptional down-regulation mechanism. In addition, ZnO NPs and ZnSO4 induced similar molecular consequences and exhibited the same Zn chemical speciation (100 % of Zn complexes) in the hippocampal region evidenced by XAFS analysis, suggesting that the observed biological effects were mainly derived from Zn2+ released from the ZnO NPs. This study not only evidences a new pathway for the impact of ZnO NPs on the brain, but also identifies the origin of the impact as ionic Zn, which provides the basis for safe-by-design of ZnO NPs.</p
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