907 research outputs found
Measuring accuracy of delivery quantities from ZF Aftermarket Frydlant
No full textBakalářská práce na téma Statistické měření přesnosti dodávek výrobků od ZF Aftermarket Frýdlant je zaměřena na aplikaci statistických metod, díky kterým je možné získat potřebné informace o tom, jak si pobočka ZF Aftermarket Frýdlant stojí v roli dodavatele.V teoretické části bakalářské práce jsou uvedeny poznatky týkající se dodavatelsko-odběratelských vztahů, logistiky a statistických analýz. V praktické části je popsána práce s vnitřními systémy společnosti ZF Aftermarket Frýdlant a dále s předplacenými programy od společnosti Microsoft jako jsou MS Word, MS Excel a MS Access. Tyto programy napomáhají vytvoření databáze, která bude sloužit jako týdenní report pro Supply Chain Managera a vedení společnosti pobočky ZF Aftermarket Frýdlant.Cílem práce je vytvoření sebereflexního zhodnocení pobočky ZF Aftermarket Frýdlant v roli dodavatele.The bachelor thesis Measuring accuracy of delivery quantities from ZF Aftermarket Frydlant is focused on the application of statistical methods, which enables us to obtain the necessary information on how the ZF Aftermarket Frýdlant branch proves itself to be a supplier.The theoretical part of the bachelor thesis presents current knowledge of supplier-buyer relationships, logistics and statistical analyses. In the practical part of this work, the author works with ZF Aftermarket Frýdlant internal systems, as well as prepaid Microsoft applications such as MS Word, MS Excel and MS Access. These applications help to create the database which would be used as a weekly report for the RMG Manager and the management of the branch ZF Aftermarket Frýdlant. The main aim of this thesis is to create a self-reflective evaluation of the branch ZF Aftermarket Frýdlant as a supplier
Study on soil moisture remote sensing
No full textA series of field and aircraft experiments have been done in quantifying the capabilities of passive microwave sensors for the remote sensing of soil moisture. In this paper we present the brief characters of the multi-frequency microwave radiometer, and discuss the results of above experiments. The 2.1-cm wavelength radiometer has been shown to be the best single sensor for soil moisture measurement. While the results from those experiments verify the basic relationship between sensor's measurement and soil moisture, they also demonstrate the limited utility of a single-sensor approach to soil moisture, prediction for a wide variety of surface conditions
Next-Generation Sequencing: Application in Liver Cancer—Past, Present and Future?
No full textHepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying pathobiological layers resulting in hepatocarcinogenesis. More recently, improvements of sophisticated next-generation sequencing (NGS) technologies have enabled complete and cost-efficient analyses of cancer genomes at a single nucleotide resolution and advanced into valuable tools in translational medicine. Although the use of NGS in human liver cancer is still in its infancy, great promise rests in the systematic integration of different molecular analyses obtained by these methodologies, i.e., genomics, transcriptomics and epigenomics. This strategy is likely to be helpful in identifying relevant and recurrent pathophysiological hallmarks thereby elucidating our limited understanding of liver cancer. Beside tumor heterogeneity, progress in translational oncology is challenged by the amount of biological information and considerable “noise” in the data obtained from different NGS platforms. Nevertheless, the following review aims to provide an overview of the current status of next-generation approaches in liver cancer, and outline the prospects of these technologies in diagnosis, patient classification, and prediction of outcome. Further, the potential of NGS to identify novel applications for concept clinical trials and to accelerate the development of new cancer therapies will be summarized
Development of nitrile-functionalized ionic liquids for C-C coupling reactions: Implication of carbene and nanoparticle catalysts
No full textA series of nitrile-functionalized imidazolium salts (many of which are liquid at room temperature) have been prepared. The reactivity of these salts with PdCl(2) has been studied, resulting in salts containing a tetrachloropalladate dianion or compounds in which the nitrile substituent coordinates to the palladium center. Further derivation of the latter compounds affords carbenes. All the new compounds have been characterized by spectroscopic methods and nine of them by single-crystal X-ray diffraction. The catalytic activity of the different palladium salts in Suzuki, Stille, and Heck reactions has been evaluated in some of the nitrile-functionalized ionic liquids (ILs) and compared with that of nonfunctionalized ILs, providing insights into the nature of the actual catalyst. In some instances, palladium nanoparticles have been identified, but the nature of the catalyst strongly depends on the IL employed
Zircon U-Pb age, element and C-O isotope geochemistry of post-collisional mafic-ultramafic rocks from the Dabie orogen in east-central China
No full textRemarkable anion and cation effects on Stille reactions in functionalised ionic liquids
No full textTask-specific ionic liquids bearing nitrile functional groups attached to the cation and nitrogen-donor-containing anions strongly affect the efficiency of the Stille cross-coupling, influencing, the nature of the catalyst and its stability. The relative strengths of the coordinating power of the cations and anions are varied and compared, and under certain conditions nanoparticles are observed
Half-ZF beamforming scheme for downlink two-user multiple input single output-based non-orthogonal multiple access systems
No full textThe authors investigate the beamforming (BF) problem to minimise the power consumption for the downlink 2-user multiple input single output-based non-orthogonal multiple access system. Inspired from the conventional zero-forcing (ZF) scheme, they propose the Half-ZF scheme which only mitigates the interference introduced by the signal of the cell-interior user through the ZF method. Meanwhile, the interference introduced by the signal of the cell-edge user is removed through the SIC technology. We derive the closed-form expression for the BF vectors of the two users under the Half-ZF scheme. The optimal power consumption for the Half-ZF scheme is analysed and the corresponding solution of the BF factors are also obtained. Compared with the conventional ZF scheme, both the Half-ZF scheme and the existing quasi-degradation (QD) scheme can achieve lower power consumption than the ZF scheme. However, the Half-ZF scheme can achieve this advantage under more relaxed conditions. Consequently, the Half-ZF scheme consumes lower power than the QD scheme when combined with the ZF scheme in practical systems.SCI(E)ARTICLE101633-16401
One-hybrid system for detection of ZF–DNA interactions () Schematic of genetic selection system for interrogating ZF–DNA interactions
No full text<p><b>Copyright information:</b></p><p>Taken from "Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells"</p><p>Nucleic Acids Research 2005;33(18):5978-5990.</p><p>Published online 26 Oct 2005</p><p>PMCID:PMC1270952.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> () Plasmids for one-hybrid genetic selection system. The reporter gene, either chloramphenicol acetyltransferase (CAT), or GFP is located downstream from a weak derivative promoter (P) on pDB series plasmids. A 9 bp target site for binding by the ZF is located at a specific distance from the start of transcription. On the pA series of plasmids, the gene for the ZF is fused to a fragment of the α-subunit of RNA polymerase ([]) via a sequence coding for an amino acid linker. Binding of the RpoA[1–248]–ZF fusion to the 9 bp site in the reporter plasmid recruits the other RNA polymerase subunits to stimulate transcription of the reporter gene
Linear Estimate of the Number of Zeros of Abelian Integrals for a Kind of Quartic Hamiltonians
No full textAbstractAn upper bound B(n)⩽7n+5 is derived for the number of zeros of Abelian integrals I(h)=∮Γhg(x, y)dy−f(x, y)dx on the open interval Σ, where Γh is an oval lying on the algebraic curve H(x, y)=12y2+U(x)=h, degU(x)=4, and Σ is the maximal interval of existence of Γh. f(x, y), g(x, y) are polynomials of x and y and n=max{degf(x, y), degg(x, y)}
Systematic Analysis of Zinc Finger-Homeodomain Transcription Factors (ZF-HDs) in Barley (Hordeum vulgare L.)
No full textZinc finger-homeodomain transcription factors (ZF-HDs) are pivotal in regulating plant growth, development, and diverse stress responses. In this study, we found 8 ZF-HD genes in barley genome. Theses eight HvZF-HD genes were located on five chromosomes, and classified into ZHD and MIF subfamily. The collinearity, gene structure, conserved motif, and cis-elements of HvZF-HD genes were also analyzed. Real-time PCR results suggested that the expression of HvZF-HD4, HvZF-HD6, HvZF-HD7 and HvZF-HD8 were up-regulated after hormones (ABA, GA3 and MeJA) or PEG treatments, especially HvZF-HD6 was significantly induced. These results provide useful information of ZF-HD genes to future study aimed at barley breeding
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