45 research outputs found
Flow State at Impeller Inlet: Optimization of Conical Frustum Section of Elbow Inlet Conduit in Large Low-Lift Pump Station
No full textIn large low-lift pump stations, the pump assembly comprises an inlet conduit, a pump, and an outlet conduit. A short conical frustum section that connects the elbow section with the impeller inlet directly affects the impeller inflow state, thereby influencing the overall performance. Therefore, investigating the conical frustum section contributes to studying the effect of inflow states on the performances of pump assemblies and similar
pumping systems. To improve the pump assembly efficiency, three parameters of the conical frustum section, i.e., the contraction angle, height, and centerline inclination angle, are investigated and optimized via univariate and multivariate analyses. The flow field and external characteristics of the pump assembly are investigated via computational fluid dynamics simulation with a constant head. Furthermore, a comprehensive analysis and discussion of the performance improvement mechanisms are presented. The results indicate that the axial velocity distribution at the impeller inlet conforming to the cascade high-efficiency characteristics will achieve a better pump performance compared with a uniform distribution. The pump efficiency distribution can be predicted and visualized based on the cascade efficiency characteristics and the flow state at the impeller inlet using a machine learning method. In addition, the directions and distribution of the lateral and axial components of the inflow velocities have great impacts on the circulation distribution. A sensible circulation distribution at the guide vane outlet can suppress the
entropy production and reduce hydraulic loss of the outlet conduit. In this case, a significant increase in the pump assembly efficiency is obtaine
Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP+
No full textIncreasing evidence has solidified the involvement of α-synuclein (α-Syn) and neurotoxins in the pathogenesis of Parkinson’s disease (PD), suggesting a combination of genetic and environmental influences. 2,3,5,4’-Tetrahydroxystilbene -2-O-β-D-glucoside (TSG) is one of the main active components extracted from Polygonum multiflorum. The purpose of the present study was to investigate the effects of TSG on α-Syn aggregation, mitochondrial dysfunction, oxidative stress and apoptosis in vitro. A53T mutant α-synuclein-transfected cells (A53T AS cells) plus MPP+The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Energy saving and safe operation of Tidal Pumping Stations
No full textTidal pumping station pumps would consume lots of energy for pumping massive water. This paper provides an effective method to optimize operating schedules of the tidal pumping stations. A multi-objective model was proposed to minimize the total switching times and energy power. In the model, sub-periods are divided according to heads. A classical tidal pumping station, which mainly serves for the China's South to North Water Transfer Project, is performed as a case. As the energy consumption per unit pumped decreases, the switching times increases, and the operational reliability of the T-PS decreases. The optimal operation scheme reduces the switching times by about 58.824% and saves the energy consumption per unit pumped by about 3.803%, respectively. Therefore, the optimal operation scheme not only has excellent safety but also effectively reduces the operation energy consumption. Thus, this paper could provide effective optimized operation schedules for tidal-pumping stations
Estimation of Water Environment Capacity:Example as Four Basin in Shandong Province, China
No full textAbstractEstimating of the water environment capacity is an important content of the assessment of regional environmental impact. This article estimates the environmental capacity of surface water of the Yellow River basin, Haihe River basin, Huaihe River basin, Jiaodong Peninsula rivers basin in Shandong based on discussing the concept of water environmental capacity and estimation methods. This article selects the appropriate water quality model and determines the appropriate parameters looking the basin divided unit as the basic unit of the water environment capacity, based on the results of the division of surface water basin and the comprehensive comparison of the multiple water quality model. Then the author calculates the water environmental capacity and gets the control unit of the water environmental capacity, the results will be visualized feedback by GIS. The study has important reference value for assessment of regional environmental and a reasonable estimate of the water environmental capacity
Preparation and characterization of polyethylene–clay nanocomposites by using chlorosilane‐modified clay
No full textThe prodrome of migraine: mechanistic insights and emerging therapeutic strategies
No full textMigraine is a common clinical chronic neurovascular disease characterized by recurrent, mostly unilateral, moderate or severe, pulsatile headache. It can be divided into four clinical stages: premonitory (prodrome), aura, headache and postdrome. The early warning value of the prodrome in migraine has been largely verified in various studies. In fact, the prodrome of migraine has received increasing attention as it can serve as an ideal therapeutic window for early intervention and effective treatment of migraine. In recent years, the pathophysiological and molecular biological mechanisms in the prodromal stage of migraine have been extensively studied, and great progress has been made in understanding the disease. This review paper aims to provide an overview of recent studies mainly focused on the prodrome of migraine, discuss the biological mechanisms underlying the clinical profile, and reveal novel therapeutic strategies for preventing or blocking migraine onset during its prodrome
Conformation Analysis of Soybean Protein in Reverse Micelles by Circular Dichroism Spectroscopy
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