4,088 research outputs found
Interface structure of poly(ethylene terephthalate)/silica nanocomposites
No full textThe interface structure of the poly(ethylene terephthalate) (PET)/silica nanocomposites was characterized by Fourier transform infrared and solid-state nuclear magnetic resonance. Our study reveals that PET chains are grafted onto the surface of silica nanoparticles, and they form branched and lightly crosslinking structures during the polycondensation. Gel permeation chromatography measurements
indicate that the grafted PET chains have a lower molecular weight and broader distribution. Furthermore,a model has been developed to elucidate the interaction of an entanglement network between silica and PET chains that lead to enhancements of G′, G〞and η* values of PET/2 wt% silica
nanocomposites.The interface structure of the poly(ethylene terephthalate) (PET)/silica nanocomposites was characterized by Fourier transform infrared and solid-state nuclear magnetic resonance. Our study reveals that PET chains are grafted onto the surface of silica nanoparticles, and they form branched and lightly crosslinking structures during the polycondensation. Gel permeation chromatography measurements
indicate that the grafted PET chains have a lower molecular weight and broader distribution. Furthermore,a model has been developed to elucidate the interaction of an entanglement network between silica and PET chains that lead to enhancements of G′, G〞and η* values of PET/2 wt% silica
nanocomposites
Co-delivery of Aurora-A inhibitor XY-4 and Bcl-xl siRNA enhances antitumor efficacy for melanoma therapy
No full textXingmei Duan,1,2,* Minjie Mu,3,* Junfeng Yan,1 Lan Bai,1 Lei Zhong,1 Yuxuan Zhu,1 Haixia Pan,1 Mei Zhang,3 Jianyou Shi1,3 1Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People`s Hospital, Chengdu, 2State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 3Key Laboratory Standardization of Chinese Herbal Medicines of Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Medicine (TCM), Chengdu, People’s Republic of China *These authors contributed equally to this work Background: The newly synthesized Aurora-A kinase inhibitor XY-4 is a potential anti-cancer agent, but its hydrophobicity and limited efficiency restrict further application. Nanotechnology based combined therapy provides an optimized strategy for solving these issues.Methods: In this study, the newly synthesized Aurora-A kinase inhibitor XY-4 and Bcl-xl targeted siRNA were co-delivered by cationic liposomes, creating an injectable co-delivery formulation. The anti-cancer ability and mechanisms of XY-4/Bcl-xl siRNA co-loaded cationic liposomes were studied both in vitro and in vivo.Results: The prepared liposomes had a mean particle size of 91.3±4.5 nm with a zeta potential of 38.5±0.5 mV and were monodispersed (Polydispersity index =0.183) in water solution, with high drug loading capacity and stability. Intriguingly, the positive charges of co-delivery liposomes not only facilitated gene delivery, but also obviously enhanced drug uptake. The XY-4/Bcl-xl siRNA co-loaded cationic liposomes demonstrated enhanced anti-cancer effects on B16 melanoma cells in vitro by activation mitochondrial apoptosis pathway. Moreover, intratumoral injection of this co-delivery formulation efficiently inhibited the growth of a B16 melanoma xenograft model in vivo.Conclusion: By co-delivering Aurora-A kinase inhibitor XY-4 and Bcl-xl targeting siRNA in a nanoformulation, our study supplied a potential combination strategy for melanoma therapy. Keywords: RNA interference, Aurora-A kinase inhibitor, liposome, co-delivery, melanoma, apoptosi
rxylib: Import XY-Data into R
No full textProvides access to the 'xylib' C library for to import xy data from powder diffraction, spectroscopy and other experimental method
An open-boundary integrable model of three coupled XY spin chains
No full textThe integrable open-boundary conditions for the model of three coupled one-dimensional XY spin chains are considered in the framework of the quantum inverse scattering method. The diagonal boundary K-matrices are found and a class of integrable boundary terms is determined. The boundary model Hamiltonian is solved by using the coordinate space Bethe ansatz technique and Bethe ansatz equations are derived. (C) 1998 Elsevier Science B.V
Disentanglement of two qubits coupled to an XY spin chain: Role of quantum phase transition
No full textWe study the disentanglement evolution of two spin qubits which interact with a general XY spin-chain environment. The dynamical process of the disentanglement is numerically and analytically investigated in the vicinity of a quantum phase transition (QPT) of the spin chain in both weak and strong coupling cases. We find that the disentanglement of the two spin qubits may be greatly enhanced by the quantum critical behavior of the environmental spin chain. We give a detailed analysis to facilitate the understanding of the QPT-enhanced decaying behavior of the coherence factor. Furthermore, the scaling behavior in the disentanglement dynamics is also revealed and analyzed
Rényi entropy and subsystem distances in finite size and thermal states in critical XY chains
No full textWe study the Rényi entropy and subsystem distances on one interval for the finite size and thermal states in the critical XY chains, focusing on the critical Ising chain and XX chain with zero transverse field. We construct numerically the reduced density matrices and calculate the von Neumann entropy, Rényi entropy, subsystem trace distance, Schatten two-distance, and relative entropy. As the continuum limit of the critical Ising chain and XX chain with zero field are, respectively, the two-dimensional free massless Majorana and Dirac fermion theories, which are conformal field theories, we compare the spin chain numerical results with the analytical results in conformal field theories and find perfect matches in the continuum limit
Do deep regional trade agreements strengthen anti‐corruption? A social network analysis
No full textThis paper adds to research on the international drivers of corruption and anti-corruption by focusing on the influence of regional trade agreements (RTAs). Using cross-national data and employing a social network analysis, we provide descriptions of the evolution of deep integration of RTAs' network in anti-corruption and transparency with a comprehensive view in which we utilise the network's Closeness, Harmonic, Betweenness, Eigenvector, and PageRank centralities to demonstrate the positions of member countries. We examine the relations of the positions of member countries in the deep RTAs' network and the performance of those countries in fighting corruption. Our empirical results suggest that the countries which hold dominant positions in the deep RTAs' network may be associated with better performance in fighting corruption. At the same time, countries which may have traditionally lagged in the enforcement of anti-bribery and corruption laws will benefit through the transfer of best practices and technical expertise in rulemaking and enforcement by using their positions in the deep RTAs' network. Furthermore, our results indicate that the provisions related to anti-corruption or transparency in RTAs will play more important roles in fighting public sector corruption for member countries. The findings are robust to alternate corruption and governance measures
XY displacement device
No full textAn XY-displacement device (1) with a four-fold symmetry comprises a reference frame (10); an object mount (20) for holding an object (22) to be displaced; an X-manipulator (100) coupled between the reference frame (10) and the object mount (20), which provides a rigid coupling between the object mount (20) and a piezoelectric X-actuator (140), allows a Y-displacement of the object mount (20) relative to the reference frame (10), and counteracts a Z-displacement of the object mount (20) relative to the reference frame (10); ; and a Y-manipulator (200) coupled between the reference frame (10) and the object mount (20), which provides a rigid coupling between the object mount (20) and a piezoelectric Y-actuator (240), allows an X-displacement of the object mount (20) relative to the reference frame (10), and counteracts a Z-displacement of the object mount (20) relative to the reference frame (10).Applied Science
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