491 research outputs found

    Supplemental Material - Identification of shared mechanisms and targets between immune checkpoint inhibitor-associated myocarditis and autoimmune myocarditis

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    Supplemental Material for Identification of shared mechanisms and targets between immune checkpoint inhibitor-associated myocarditis and autoimmune myocarditis by Kai Yang, Min Zhang, Dong Li, Yuandong Yu, Fengjun Cao and Guoxing Wan in European Journal of Inflammation.</p

    Analysing the successful reasons of Time Fengjun entertainment based on marketing mix theory

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    This study examined the operational strategies of Beijing Time Fengjun Entertainment in the Chinese market. Using the Marketing Mix Theory, it analysed Time Fengjun’s promotion, product, and place strategies. Effective promotion, high-quality products, and diverse marketing channels were found to positively influence consumer purchasing intent. The research focused on understanding the factors driving Time Fengjun’s success. It provided valuable insights for entertainment companies operating in China, aiding in the formulation of effective strategies. Multiple sources, including academic papers, industry reports, and case studies, support the research findings. The analysis confirmed that Time Fengjun’s success stems from its effective promotions, high-quality products, and diverse marketing channels. They serve as a roadmap for other companies seeking success in the dynamic Chinese entertainment industry. The study’s implications were relevant to entertainment companies aiming to enter or expand in China. Understanding the identified success factors enables the development of strategies to navigate the market and increase the likelihood of success. In conclusion, this study unveils the operational strategies of Beijing Time Fengjun Entertainment and highlights the key factors driving its success. It offered actionable insights for entertainment companies operating in China

    The multicomparative 2-n-way genome suite

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    To effectively analyze the increasing amounts of available genomic data, improved comparative analytical tools that are accessible to and applicable by a broad scientific community are essential. We built the “2-n-way” software suite to provide a fundamental and innovative processing framework for revealing and comparing inserted elements among various genomes. The suite comprises two user-friendly web-based modules. The 2-way module generates pairwise whole-genome alignments of target and query species. The resulting genome coordinates of blocks (matching sequences) and gaps (missing sequences) from multiple 2-ways are then transferred to the n-way module and sorted into projects, in which user-defined coordinates from reference species are projected to the block/gap coordinates of orthologous loci in query species to provide comparative information about presence (blocks) or absence (gaps) patterns of targeted elements over many entire genomes and phylogroups. Thus, the 2-n-way software suite is ideal for performing multidirectional, non-ascertainment-biased screenings to extract all possible presence/absence data of user-relevant elements in orthologous sequences. To highlight its applicability and versatility, we used 2-n-way to expose approximately 100 lost introns in vertebrates, analyzed thousands of potential phylogenetically informative bat and whale retrotransposons, and novel human exons as well as thousands of human polymorphic retrotransposons

    A BI-DIRECTIONAL ACTIVE CELL BALANCING OPTIMIZATION BASED ON STATE-OF-CHARGE ESTIMATION

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    Recently, Electric Vehicles (EVs) have received extensive consideration since they offer a more sustainable and greener transportation alternative compared to fossil-fuel propelled vehicles. Lithium-ion batteries are increasingly being considered in EVs due to their high energy density, slow loss of charge when not in use, and for lack of hysteresis effect. Conventionally, the batteries are connected in series to achieve the load voltage requirements. However, for the batteries with intrinsic discrepancies or different initial states, cell balancing is a concern because it is the weakest cell that determines the empty point for the battery and an undercharged series cell will shorten the lifetime of the entire pack. The imbalance potential of the battery behaves as the way of State-of-Charge (SOC) mismatch and it’s also temperature dependent. Therefore, in this thesis, an active cell balancing optimization was proposed and conducted in MATLAB to optimize battery unused capacity and thermal effect simultaneously based on bi-directional balancing system and pre-estimated SOC. The bi-directional balancing system was physically built based on “Fly-back” converter to compare balancing performance in discharging, idle, and plug-in charging mode. Moreover, a battery combined model worked collaboratively with robust state and parameter estimation strategies, namely Extended Kalman Filter (EKF) and Smooth Variable Structure Filter (SVSF) in order to estimate SOC for cell balancing. As a result, the proposed method can effectively optimize SOC mismatch around 2.5%. Meanwhile, more uniform temperature was achieved and the maximum temperature can be reduced about 7 ℃.ThesisMaster of Applied Science (MASc

    Topological Aspects of Ferromagnets and Antiferromagnets

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    This dissertation presents our theoretical study of fundamental topological properties of ferromagnetic and antiferromagnetic systems, including topological magnetic excitations and topological magnetic textures. In the first part, we explored the topological magnonic phases in various systems with Dzyaloshinskii-Moriya interaction using a linear spin-wave theory. We have calculated the magnonic Chern number, topological phase diagram, and magnon thermal Hall conductivity at low temperature with tunable interactions due to the lattice deformation. In particular, we have investigated the topological phase transitions between distinct topological magnonic phases characterized by magnonic Chern numbers. We have also studied the magnon band topology and magnonic edge states in each topological phase. We found a sign reversal of the thermal Hall conductivity during topological phase transitions. We explicitly demonstrated the correspondence of thermal Hall conductivity with the topological edge states and their propagation directions. In the second part, a magnonic metamaterial in the presence of spatially modulated Dzyaloshinskii-Moriya interaction was theoretically proposed and demonstrated by micromagnetic simulations. By analogy to the fields of photonics, we first established magnonic Snell’s law for spin waves passing through an interface between two media with different dispersion relations due to different Dzyaloshinskii-Moriya interactions. Based on magnonic Snell’s law, we found that spin waves can experience total internal reflection. The critical angle of total internal reflection was strongly dependent on the sign and strength of Dzyaloshinskii-Moriya interaction. Furthermore, spin-wave beam fiber and spin-wave lens were designed by utilizing the artificial magnonic metamaterials with inhomogeneous Dzyaloshinskii-Moriya interactions. In the last part, we studied the impact of spin Hall torque, spin transfer torque, and topological torque on the velocity-current relation of antiferromagnetic skyrmions with the aim of reducing the deformation. Using a combination of micromagnetic simulations and analytical derivations, we demonstrated that the lateral expansion of the antiferromagnetic skyrmion is reminiscent of the well-known Lorentz contraction identified in one-dimensional antiferromagnetic domain walls. We also showed that in the flow regime the lateral expansion is accompanied by a progressive saturation of the skyrmion velocity when driven by spin Hall and topological torques. This saturation occurs at much smaller velocities when driven by the topological torque, while the lateral expansion is reduced, preventing the skyrmion size from diverging at large current densities. Our findings suggested that a compromise must be made between skyrmion velocity and lateral expansion during the device design. In this respect, exploiting the topological torque could lead to better control of the skyrmion velocity in antiferromagnetic racetracks

    Algorithm and simulation of automatic recommendation based on information requirements

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    Information acquisition is the prerequisite for command decision-making. In the era of big data filled with massive information, the useful information is submerged in useless information. How to efficiently obtain the useful information needed by command personnel is the key to improve operational command effectiveness. The author uses the information automatic recommendation algorithm, on the basis of the information requirements proposed by the commander, extracts the useful information and automatically recommends to commander based on the text similarity. It can effectively improve the timeliness of information acquisition and command decision-making, and thus improve the effectiveness of combat command

    Setting of Natural Fracture Splitting Surface on Connecting Rod and Its Formation Mechanism

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    To break through the limitation of fracture splitting process on material selection and solve problems during fracture splitting such as parts tearing, failing to split, dropping dregs, fracture surface deformation and so on, a new technique of setting natural splitting surface in casting blank is proposed, aiming to achieve brittle fracture along pre-set surface during fracture splitting process. In this research, casting blanks are produced with metal molds. A layer of AZ31 foil is set in advance before casting, the layer interacts with liquid LD10 aluminum alloy, forming a brittle interface layer across the whole casting, then a fracture splitting hole is machined in the middle of the casting blank and cracking grooves are machined on the inner hole near the interface to achieve fracture splitting. Experiment revealed that the initial crack on the specimen starts from the root of the cracking groove, and the crack basically expands along the pre-set fracture splitting surface. The fracture surface is characterized by flaky brittle fracture. There is residual magnesium and pellumina, which have characteristics of melt with low-melting point, and micro-porosity in the fracture. Further analysis suggests that the formation mechanism of a natural fracture splitting surface can be described as follows: the magnesium foil with strong oxidation in high-temperature alloy liquid interacts with the pellumina at the front of liquid flow, which forms a interface. Meanwhile a layer of melt with a low-melting point forming as a result of interface reaction is pushed to the edge of the grain boundary, and surface liquid film shrinks to be micro-porosity. With such a combined effect it finally forms the brittle surface, which provides the condition for conducting subsequent fracture splitting process

    The Way to Realize the Morality-establishing and Talent-cultivating Responsibilities of Postgraduate Tutors in Agricultural and Forestry Universities

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    With the continuous expansion of postgraduate enrollment in China, the phenomenon of postgraduate tutors’ experiencing dereliction of duties, morality and behavior in colleges and universities has become prominent in recent years. It has repeatedly attracted widespread attention from the whole society, producing a negative impact on postgraduate education. Agricultural and forestry universities take root at the grassroots level, serve agriculture, rural areas and farmers, have simple and practical education characteristics, and have made positive adjustments to mutual assistance between teachers and students, teachers’ self-examination and regulatory system. This article analyzes the reasons for the current unethical and dishonest behaviors of postgraduate tutors in colleges and universities from the perspective of postgraduate tutors, and puts forward the implementation mechanism of the morality-establishing and talent-cultivating responsibilities of postgraduate tutors in agricultural and forestry universities combined with the school-running characteristics and practical experience of agricultural and forestry universities, so as to provide a reference for the construction of postgraduate tutor teams in colleges and universities
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