92 research outputs found

    A three-stage sequential surgical approach to a more efficient management of clinical stage 4 diabetic foot ulcers

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    Background:It has been a great challenge to treat clinical stage 4 Diabetic foot ulcers (DFUs) due to high rates of major amputations and prolonged healing time. This study aimed to assess the effectiveness of a three-stage sequential surgical approach, which based on the Integrated Surgery Wound Treatment (ISWT) mode, to manage clinical stage 4 DFUs and compare the benefit of incorporating tibial cortex transverse transport (TTT) surgery at stage 3 treatment. Methods: Twenty-three patients with clinical stage 4 DFUs aged 45–75 years treated between January 2022 and February 2023 were retrospectively analyzed. Eleven patients (Group A) received wound debridement, antibiotic- loaded bone cement (ALBC) at stage 1 treatment, percutaneous transluminal angioplasty (PTA), wound debridement, and ALBC at stage 2 treatment, and skin grafting with TTT at stage 3 treatment, while twelve patients (Group B) received the same treatment without TTT. Assessed clinical outcomes included length of hospital stay, ulcer healing duration, ulcer recurrence rate, reintervention (re)-PTA rate, amputation rate, mortality rate, visual analog scale (VAS) scores, ankle-brachial index (ABI), and two-point discrimination (2-PD) ability. The computed tomographic angiography (CTA) was used to evaluate vascular hyperplasia. Results: Group A showed no occurrences of re-PTA ( = 0.037) and similar ulcer healing times ( = 0.975) compared to Group B. Ulcer outcome, amputation, and mortality rate were also alike in the two groups ( > 0.05). One year after surgery, Group A demonstrated improvement in VAS scores, ABI, and 2-PD, while Group B showed no significant changes. Additionally, Group A exhibited enhanced lower limb artery characteristics compared to Group B. Conclusion: The sequential three-stage approach based on the ISWT mode effectively manages clinical stage 4 DFUs. Incorporating TTT surgery at stage 3 extends the benefits of PTA surgery

    Illustrations and the Eco-Reality of The Velveteen Rabbit

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    This presentation will offer a look into the Japanese edition of The Velveteen Rabbit, adapted and illustrated by Komako Sakai, as a miniature ecosystem of words and pictures that interact with each other and create meaning through counterpoints. I will analyze primarily the visual narrative, namely Sakai’s use of color and light, relative sizes, and distance and frames in her paintings. I will also focus on the depiction of and implication about nature and how illustrating techniques contribute to our understanding of the story. By acknowledging the interests of animal others (even toy animals) and identifying whether the natural environment is implicated in the story, such reading engages us in the ethics of human relationships with built and natural environments, as well as nonhuman beings

    Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction.

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    Fibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the onset of AMI and remained at high for 7 days, and the FGF21 level (OR: 16.93; 95% confidence interval (CI): 2.65-108.05; P = 0.003) was identified as an independent factor associated with the presence of AMI. On the 7th day, FGF21 levels were significantly higher in the patients who subsequently developed re-infarction within 30 days than in the patients who did not develop re-infarction (with vs. without re-infarction: 0.45 (0.22-0.64) vs. 0.21 (0.15-0.29) ng/mL, P = 0.014).The level of serum FGF21 is independently associated with the presence of AMI in Chinese patients. High FGF21 levels might be related to the incidence of re-infarction within 30 days after onset

    The Estimation of Forest Carbon Sink Potential and Influencing Factors in Huangshan National Forest Park in China

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    In this study, the biomass expansion factor (BEF) method was combined with the tree growth function in order to obtain a more accurate growth function of tree species through the fitting of different growth functions to tree growth, and to determine the characteristics of the forest carbon stock as well as the carbon sink potential of Huangshan National Forest Park (HNFP) in China. The carbon sink potential of each tree species and the integrated influencing factors, such as the stand and soil, were directly represented by structural equation modelling (SEM) to clarify the size and path of each influencing factor against the carbon sink potential. The results showed the following: (1) the logistic growth function fitting results for the seven major tree species in HNFP were better than those from the Richard&ndash;Chapman growth function, and the R2 was greater than 0.90. (2) In 2014, the total carbon stock of the forest in HNFP was approximately 9.59 &times; 105 t, and the pattern of carbon density, in general, was higher in the central region and the northeastern region and lower in the northern and southern regions, while the distribution of carbon density was lower in the northern and southern regions. The carbon density pattern generally showed a higher distribution in the central and northeastern regions and a lower distribution in the northern and southern regions; most of the high-carbon-density areas were distributed in blocks, while the low-carbon-density areas were distributed sporadically. (3) The total carbon sink of the forest in HNFP was 8.26 &times; 103 t in 2014&ndash;2015, and due to the large age structure of the regional tree species, the carbon sinks of each tree species and the total carbon sink of HNFP showed a projected downward trend from 2014 to 2060. (4) For different tree species, the influencing factors on carbon sink potential are not the same, and the main influence factors involve slope position, slope, altitude, soil thickness, etc. This study identified the carbon stock and carbon sink values of the forest in HNFP, and the factors affecting the carbon sink potential obtained by SEM can provide a basis for the selection of new afforestation sites in the region as well as new ideas and methods to achieve peak carbon and carbon neutrality both regionally and nationally in the future
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