43 research outputs found
Yoğun bakım hastalarında diyabetes mellitus malnütrisyonla ilişkili midir? Diyabet ve malnütrisyon
No full textAmaç: Hastalık türleri ve tedavi yöntemleri yetersiz beslenmenin alevlenmesine yol açabilir. Bu çalışmada, üçüncü basamak bir hastanenin yoğun bakım ünitesinde (YBÜ) diyabetes mellituslu hastaların beslenme durumunun araştırılması amaçlandı.Yöntem: Yüz doksan iki hasta çalışmaya dahil edildi ve iki gruba ayrıldı. Çalışma grubuna tip 2 diyabetli 77 hasta, kontrol grubuna ise diyabeti olmayan 115 hasta alındı. Beslenme durumu ve riski NRS (Nutritional Risk Screening) 2002, Nutric skoru, MNA (Mini-Nutritional Assessment) ve MUST (Malnutrition Universal Screening Tool) testleri ile değerlendirildi.Bulgular: Gruplar NRS 2002 (3.37 ± 1.84 vs. 3.93 ± 1.72, p = 0.075), Nutric skoru (4.61 ± 1.85 vs. 4.56 ± 1.85, p = 0.869), MNA (8.0 ± 3.1 vs. 7.1 ± 3.2, p = 0.068) ve MUST skoruna (1.62 ± 1.46 vs. 1.81 ± 1.59, p = 0.456) göre benzer bulundu.Sonuç: Bu çalışmada, malnütrisyon riski her iki grupta benzer bulundu. Bu sonuç malnütrisyonun diyabete ek olarak eşlik eden diğer hastalıklarla da ilişkili olduğunu düşündürmektedir.Aim: Types of diseases and treatment modalities can also lead to the exacerbation of malnutrition. The aim of this study was to investigate nutritional status of patients with diabetes mellitus in the intensive care unit of a tertiary hospital.Materials and methods: One hundred and ninety-two patients were enrolled and divided into two groups. The study group comprised of 77 patients with type 2 diabetes and the control group comprised of 115 patients without diabetes. The nutritional risk assessment was tested with NRS (Nutritional Risk Screening) 2002, Nutric score, MNA (Mini-Nutritional Assessment) and MUST (Malnutrition Universal Screening Tool). Results: The groups were comparable according to the NRS 2002 (3.37 ± 1.84 vs. 3.93 ± 1.72, p = 0.075), Nutric score (4.61 ± 1.85 vs. 4.56 ± 1.85, p = 0.869), MNA (8.0 ± 3.1 vs. 7.1 ± 3.2, p = 0.068) and MUST score (1.62 ± 1.46 vs. 1.81 ± 1.59, p = 0.456). Conclusion: In this study, the risk of malnutrition is comparable in both groups. This result may suggest that malnutrition is also related to co-morbidities in addition to diabetes
D-Dimer/Fibrinogen Ratio as a Prominent Predictor of Mortality in COVID-19 Patients Admitted To the Intensive Care Unit
No full textPurpose: In this retrospective cohort study, evaluating the role of the D-dimer/fibrinogen ratio in predicting the in-hospital mortality rate of COVID-19 regardless of the presence of comorbidities was aimed.
Materials and Methods: This retrospective cohort study included patients admitted to the intensive care unit. The demographic data of the patients (sex, age, body mass index, comorbidities), their prognostic clinical scores, laboratory results, and need for and duration of invasive mechanical ventilation (IMV) were recorded.
Results: The rates of chronic renal diseases, acute renal failure, cardiac diseases, and severe sepsis were significantly higher in the exitus group. It was found that lower levels of lymphocytes were associated with increased mortality. Furthermore, neutrophil counts and the neutrophil to lymphocyte ratio (NLR) were associated with increased mortality. A higher D-dimer/fibrinogen ratio (DDFR) was a predictor of mortality but not a predictor of the duration of hospitalization in the ICU.
Conclusion: DDFR has a potential impact in anticipating mortality rates in COVID-19 patients
Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients: reply
No full textNoninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients: reply
No full textInvestigation of miRNA-199a-5p Expression and its Clinical Association With LDL Cholesterol Levels in Atherosclerosis
No full textBackground/Aim: Atherosclerosis is a chronic and progressive pathological condition marked by the accumulation of lipids, fibrous materials, and inflammatory cells, within the arterial walls. MicroRNAs (miRNAs) are single-stranded, evolutionarily conserved, non-coding small RNAs, that play a pivotal role in controlling various pathophysiological cellular functions and molecular signalling cascades associated with the development of atherosclerosis. Additionally, dysregulation in cholesterol and lipid metabolism is known to increase susceptibility to atherosclerosis. In this study, we aimed to determine the changes in serum levels of miRNA-199a-5p, examine its relationship with LDL cholesterol, and investigate its diagnostic value in patients diagnosed with atherosclerosis. Materials and Methods: MiRNA-199a-5p expression analysis was conducted using PCR on serum samples from 20 patients diagnosed with atherosclerosis and 26 completely healthy, voluntary control subjects. The blood biochemical analysis values for all groups participating in the study were obtained from their records. Results: The data analysis revealed significant up-regulation of miRNA-199a-5p in the serum of the patient group. Additionally, miRNA-199a-5p expression levels positively correlated with LDL cholesterol levels. Conclusion: miRNA-199a-5p can be considered a reliable biomarker in patients with atherosclerosis, potentially informing and guiding future therapeutic approaches. Additionally, a significant relationship was found between lipid metabolism and miRNA-199a-5p in atherosclerosis. © 2024 The Author(s).The Yeditepe University Open Access System is a compendium of indexed publications. Copyright and usage rights may be held by publishers and/or authors. The collection was established for the scientific publications prepared by Yeditepe University academicians and is to be found in the institutional archive
Knowledge and Attitudes Toward Organ Donation and Brain Death Among Medical Staff of Intensive Care Units
No full textTowards an object-oriented design ontology
No full textObject-oriented ontology, speculative realism, new materialism, and similar contemporary philosophies, proposing alternative theories to understand the world and relations within, became more prevalent and effective in the last two decades. However, expect several solitary examples; these do not seem to be having a transformative effect on design disciplines, theory, and practices. This paper initially introduces primary theorisations of object-oriented thinking and how these theories would inform design thinking, education, theory and practice. The author argues that this is not, by no means, an option or alternative, but is a necessity, an urging fundamental transformation waiting to happen, considering the current environmental, social and cultural concerns of our age
Towards an object-oriented design ontology
No full textObject-oriented ontology, speculative realism, new materialism, and similar contemporary philosophies proposing alternative non-anthropocentric theories to understand the world and relations within, became more prevalent and effective in the last two decades. However, except for severalsolitary examples, these do not seem to be having a transformative effect on design disciplines, theory, and practices. This paper initially introduces primary theorisations of object-oriented thinking and how these theories would inform design thinking, education, theory and practice. The author argues that this is not, by no means, an option or alternative but is a necessity, an urging fundamental transformation waiting to happen, considering the current environmental, social and cultural concerns of our age.</p
Towards an object-oriented design ontology
No full textObject-oriented ontology, speculative realism, new materialism, and similar contemporary philosophies proposing alternative non-anthropocentric theories to understand the world and relations within, became more prevalent and effective in the last two decades. However, except for severalsolitary examples, these do not seem to be having a transformative effect on design disciplines, theory, and practices. This paper initially introduces primary theorisations of object-oriented thinking and how these theories would inform design thinking, education, theory and practice. The author argues that this is not, by no means, an option or alternative but is a necessity, an urging fundamental transformation waiting to happen, considering the current environmental, social and cultural concerns of our age.</p
Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients.
No full textAuto-titrating noninvasive ventilation (NIV) has been developed as a new mode applying variable expiratory-positive airway pressure (EPAP) in addition to variable inspiratory pressures (IPAP), both to deliver targeted tidal volume (VT) and to eliminate upper airway resistance. The purpose of this study is to evaluate whether NIV with auto-titrating mode will decrease more PaCO2 within a shorter time compared to volume-assured mode in hypercapnic intensive care unit (ICU) patients. The hypercapnic respiratory failure patients treated with average volume assured pressure support- automated EPAP mode (group1) were compared with those treated with average volume-assured pressure support mode (group2). Two groups were matched with each other according to baseline diagnoses, demographic characteristics, arterial blood gas values, target VT settings and daily NIV usage times. Built-in software was used to gather the ventilatory parameters. Twenty-eight patients were included in group 1, and 22 in group 2. The decrease in PaCO2 had been achieved within a shorter time period in group 1 (p < 0.05). This response was more pronounced within the first 6 h (mean reduction in PaCO2 was 7 +/- 7 mmHg in group 1 and 2 +/- 5 mmHg in group 2, p = 0.025), and significantly greater reductions in PaCO2 (18 +/- 11 mmHg in group 1 and 9 +/- 8 mmHg in group 2, p = 0.008) and plasma HCO3 levels (from 32 to 30 mEq and from 35 to 35 mEq, p = 0.007) took place within first 4 days. While mean IPAP was similar in both groups, maximum EPAP, mean VT and leak were significantly higher in group 1 than in group 2 (p < 0.05). Results of this preliminary study suggest that, this new auto-titrating NIV mode may provide additional benefit on volume-assured mode in decreasing PaCO2 more efficiently and rapidly in hypercapnic ICU patients
