1,721,075 research outputs found
Long-term Stability and Hyaluronic Acid Filler Selection for Forehead Contouring
No full text: Hyaluronic acid (HA) fillers have progressed from superficial wrinkle correction to tools for deep 3-dimensional facial remodeling. The forehead, once addressed exclusively through surgical procedures or botulinum toxin, can now be effectively reshaped using HA fillers. This retrospective study evaluates the long-term outcomes of forehead contouring in 38 patients (36 males, 2 females; mean age: 47.6 y) treated between January 2021 and January 2024 using a low G' (20 Pa), monophasic cross-linked HA filler. Injections were performed perpendicularly to the frontal bone, targeting the space just above the periosteum to correct frontal bossing and restore contour. The mean volume used was 16 mL per patient. No major or minor complications occurred, and patient satisfaction, measured through Visual Analog Scale (VAS), averaged 91 at 12 months. Follow-up up to 36 months demonstrated stable aesthetic results, with no evidence of filler resorption, nodules, or irregularities. The use of a low-cohesivity, low-elasticity filler allowed for precise molding and excellent integration without visible distortion, even in the thin tissue planes of the forehead. Despite the absence of a filler specifically designed for this region, this approach proved effective, cost-efficient, and safe. These findings suggest that deep HA filler injections may offer a reliable, reversible, and long-lasting alternative to surgical forehead contouring. Further randomized, controlled trials are needed to define the ideal rheological parameters for forehead applications
Remodeling the neck and the lower jaw with Dehoxycholate injections
No full textNonsurgical cosmetic facial procedures have gained popularity in recent decades. These procedures are commonly referred to as facial rejuvenation, and only a few are performed in the neck region. Herein, the authors describe their experience with off-label use of deoxycholic acid (DC) injections on 18 patients for remodeling of the neck and lower jaw. The injection protocol was personalized for each patient, and lidocaine was always premixed with the DC. After the initial injection visit, at least 3 months passed before further injections were considered. All documented side effects, including swelling and dysesthesia, resolved spontaneously. All patients received follow-up for at least 3 months, and only 2 patients required a second session of injections. By personalizing the injection protocol for each patient, good outcomes were achieved, including aesthetic enhancement of the shape and contour of the jaw and neck. Although the study is limited by the relatively small sample size, the results are promising and warrant additional investigations
Cutaneous ulcers associated with hydroxyurea therapy
No full textHydroxyurea is an antitumoral drug mainly used in the treatment of Philadelphia chromosome-negative myeloproliferative syndromes and sickle-cell disease. Ulcers represent a rare but severe long-term adverse effect of hydroxyurea therapy. Hydroxyurea-induced ulcers are often multiple and bilateral, typically developing in the perimalleolar region, although any cutaneous district is potentially affected. They generally look small, well-defined, shallow with an adherent, yellow, fibrinous necrotic base. A constant finding is also an extremely intense, treatment-resistant pain accompanying these ulcerations. Withdrawal of the drug generally leads to spontaneous healing of these lesions. Care providers tend to show insufficient awareness of this highly debilitating cutaneous side effect, and late or missed diagnoses are frequent. Instead, regular dermatologic screening should be performed on hydroxyurea-treated patients. This article will present a comprehensive review of indexed case reports and clinical studies, followed by a discussion about treatment options aiming at increasing knowledge about this specific topic. © 2013 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved
Remodeling the neck and the lower jaw with Dehoxycholate injections
No full textNonsurgical cosmetic facial procedures have gained popularity in recent decades. These procedures are commonly referred to as facial rejuvenation, and only a few are performed in the neck region. Herein, the authors describe their experience with off-label use of deoxycholic acid (DC) injections on 18 patients for remodeling of the neck and lower jaw. The injection protocol was personalized for each patient, and lidocaine was always premixed with the DC. After the initial injection visit, at least 3 months passed before further injections were considered. All documented side effects, including swelling and dysesthesia, resolved spontaneously. All patients received follow-up for at least 3 months, and only 2 patients required a second session of injections. By personalizing the injection protocol for each patient, good outcomes were achieved, including aesthetic enhancement of the shape and contour of the jaw and neck. Although the study is limited by the relatively small sample size, the results are promising and warrant additional investigations
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