1,720,986 research outputs found
The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research
No full textWnt signaling is an important pathway in health and disease and a key regulator of stem cell maintenance, differentiation, and proliferation. During heart development, Wnt signaling controls specification, proliferation and differentiation of cardiovascular cells. In this regard, the role of activated Wnt signaling in cardiogenesis is well defined. However, the knowledge about signaling transmission has been challenged. Recently, the packaging of hydrophobic Wnt proteins on extracellular vesicles (EVs) has emerged as a mechanism to facilitate their extracellular spreading and their functioning as morphogens. EVs spread systemically and therefore can have pleiotropic effects on very different cell types. They are heavily studied in tumor biology where they affect tumor growth and vascularization and can serve as biomarkers in liquid biopsies. In this review we will highlight recent discoveries of factors involved in the release of Wnts on EVs and its potential implications in the communication between physiological and pathological heart cells
Expression and role of EpoR/Epo signaling in the biology of mouse cardiac progenitor cells
No full textLoss of cardiac mass and function induced by 17beta-oestradiol via a beta-catenin mechanism in C57Bl/6N female mice
No full textAdministration of 17 beta-Estradiol in C57Bl/6N Female Mice Leads to Cardiac Atrophy and Dysfunction via a beta-Catenin Mechanism
No full textLoss of Krueppel-like Factor 15 (KLF15) Leads to Altered Wnt-dependent Gene Regulation in Hearts With Systolic Dysfunction
No full textLoss of cardiac mass and function induced by 17beta-oestradiol via a beta-catenin mechanism in C57Bl/6N female mice
No full textAdministration of 17 beta-Estradiol in C57Bl/6N Female Mice Leads to Cardiac Atrophy and Dysfunction via a beta-Catenin Mechanism
No full textLoss of Krueppel-like Factor 15 (KLF15) Leads to Altered Wnt-dependent Gene Regulation in Hearts With Systolic Dysfunction
No full textExpression and role of EpoR/Epo signaling in the biology of mouse cardiac progenitor cells
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