1,189 research outputs found
<b>Supplemental Material - The relationship between toluene diisocyanate exposure and respiratory health problems: A meta-analysis of epidemiological studies</b>
No full textSupplemental Material for The relationship between toluene diisocyanate exposure and respiratory health problems: A meta-analysis of epidemiological studies Evangelia E Antoniou and Maurice P Zeegers in Toxicology and Industrial Health</p
Supplemental Material - Perceptions of effective policy interventions and strategies to address antibiotic misuse within primary healthcare in India: A qualitative study
No full textSupplemental Material for Perceptions of effective policy interventions and strategies to address antibiotic misuse within primary healthcare in India: A qualitative study by Mohit Nair, Nora Enge, Maurice P Zeegers and Sakib Burza in Journal of Infection Prevention</p
Antoniou_et_al.Supplementary_file_2 - The influence of airborne <i>N</i>,<i>N</i>-dimethylformamide on liver toxicity measured in industry workers: A systematic review and meta-analysis
No full textAntoniou_et_al.Supplementary_file_2 for The influence of airborne N,N-dimethylformamide on liver toxicity measured in industry workers: A systematic review and meta-analysis by Evangelia E Antoniou, Heinz-Peter Gelbke, Jochen Ballach and Maurice P Zeegers in Toxicology Research and Application</p
Antoniou_et_al.Supplementary_file_1 - The influence of airborne <i>N</i>,<i>N</i>-dimethylformamide on liver toxicity measured in industry workers: A systematic review and meta-analysis
No full textAntoniou_et_al.Supplementary_file_1 for The influence of airborne N,N-dimethylformamide on liver toxicity measured in industry workers: A systematic review and meta-analysis by Evangelia E Antoniou, Heinz-Peter Gelbke, Jochen Ballach and Maurice P Zeegers in Toxicology Research and Application</p
High vaccine effectiveness against severe COVID-19 outcomes and population preventable fraction during the Omicron era in Luxembourg:A nationwide retrospective risk factor analysis
No full textBackground: Luxembourg experienced major consecutive SARS-CoV-2 infection waves due to Omicron variants during 2022 while having achieved a high vaccination coverage in 2021. We investigated the risk factors associated to severe outcomes (i.e., hospitalisation, deaths) and estimated vaccine effectiveness (VE) as well as the role of immunity conferred by prior infections against severe outcomes in adults. Methods: We linked reported SARS-CoV-2 cases among residents aged = 20 years with vaccination data and SARS-CoV-2 related hospitalisations and deaths. Cases were followed-up until day 14 for COVID-19 related hospital admission and up to day 28 for mortality after a positive test. We analysed the association between the vaccination status and severe forms using proportional Cox regression, adjusting for previous infection, age, sex and nursing homes residency. VE was measured as 1-adjusted hazard ratio of vaccinated vs unvaccinated individuals. The population preventable fraction was computed using the adjusted hazard ratio and the proportion of cases within the vaccination category. Results: Between December 2021, and March 2023, we recorded 187 143 SARS-CoV-2 cases, 1 728 (0.93%) hospitalizations and 611 (0.33%) deaths. The risk of severe outcomes increased with age, was higher among men and nursing home residents. Compared to unvaccinated adults, VE against hospitalization was 38.8% (95%CI: 28.1%-47.8%) for a complete primary cycle of vaccination, 62.1% (95%CI: 57.0%-66.7%) for one booster, and 71.6% (95%CI: 66.7%-76.2%) for two booster doses. VE against death was respectively 49.5% (95%CI: 30.8%-63.3%), 69.0% (95%CI: 61.2%-75.3%) and 76.2% (95%CI: 68.4%-82.2%). Previous infection was not associated with lower risk of hospitalisation or mortality. The vaccination lowered mortality by 55.8 % (95%CI: 46.3%-62.8%) and reduced hospital admissions by 49.1% (95%CI: 43.4%-54.4%). Conclusions: Complete vaccination and booster but not previous infection were protective against hospitalization and death. The vaccination program in Luxembourg led to substantial reductions in SARS-CoV-2-related mortality and hospitalizations at the population level
Supplementary_Tables_1_12_Sep24_xyz268777d1d25d8 – Supplemental material for Systematic Review: Genetic Associations for Prognostic Factors of Urinary Bladder Cancer
No full textSupplemental material, Supplementary_Tables_1_12_Sep24_xyz268777d1d25d8 for Systematic Review: Genetic Associations for Prognostic Factors of Urinary Bladder Cancer by Nadezda Lipunova, Anke Wesselius, Kar K Cheng, Frederik J van Schooten, Jean-Baptiste Cazier, Richard T Bryan and Maurice P Zeegers in Biomarkers in Cancer</p
Translation and response between Maurice Blanchot and Lydia Davis
Full text linkWhen an author translates a text by another writer, this translation is one form of a response to that text. Other responses may appear in their own writings that are more inflected with their authorial persona. Lydia Davis translated six books by Maurice Blanchot, including fiction and theoretical writings. Blanchot’s concept of the récit privileges non-conventional forms of narrative and it can be considered to have influenced Davis, a view shared in critical writing about Davis. However, responses to his fiction can also be found in Davis’s work. This article reads Lydia Davis’s story “Story” as a response to Maurice Blanchot’s récit, La Folie du jour, translated by Davis as “The Madness of the Day”. Both texts develop a narrative that questions the possibility of arriving at a single story: Blanchot’s narrator cannot tell the story of how he came to have glass ground into his eyes, while Davis’s narrator must try to understand a contradictory story told to her by her lover. However, Davis responds to Blanchot by reversing the perspective in the story: where Blanchot’s narrator must and cannot create a story that explains his situation in a judicial/medical context, Davis’s narrator is struggling to understand her lover’s story which does not explain the situation that they find themselves in. Davis’s narrator is therefore motivated by an emotional need to find an acceptable story that is absent from Blanchot’s narrator. This difference in motivation is central to the difference between Davis’s and Blanchot’s approach, and complicates any reading of his influence on her because she responds to his text in her own
Relationship between multimorbidity, functional limitation, and quality of life among middle-aged and older adults: findings from the longitudinal analysis of the 2013–2020 Survey of Health, Ageing, and Retirement in Europe (SHARE)
Full text linkPURPOSE
The increased burden of multimorbidity is restricting individuals' ability to live autonomously, leading to a poorer quality of life. This study estimated trajectories of functional limitation and quality of life among middle-aged (ages 50 to 64 years) and older (aged 65 years and older) individuals with and without multimorbidity. We also assessed differences in the relationship between these two trajectories by multimorbidity status and separately for each age cohort.
METHODS
Data originated from the Survey of Health, Ageing, and Retirement in Europe (SHARE). In Luxembourg, data were obtained between 2013 and 2020, involving 1,585 respondents ≥ 50 years of age. Multimorbidity was defined as a self-reported diagnosis of two or more out of 16 chronic conditions; functional limitation was assessed by a combined (Instrumental) Activities of Daily Living (ADL/IADLI) scale; and to measure quality of life, we used the Control, Autonomy, Self-Realization, and Pleasure (CASP-12) scale. Latent growth curve modelling techniques were used to conduct the analysis where repeated measures of quality of life and functional limitation were treated as continuous and zero-inflated count variables, respectively. The model was assessed separately in each age cohort, controlling for the baseline covariates, and the estimates from the two cohorts were presented as components of a synthetic cohort covering the life course from the age of 50.
RESULTS
Middle-aged and older adults living with multimorbidity experienced poorer quality of life throughout the life course and were at a higher risk of functional limitation than those without multimorbidity. At baseline, functional limitation had a negative impact on quality of life. Furthermore, among middle-aged adults without multimorbidity and older adults with multimorbidity, an increase in the number of functional limitations led to a decline in quality of life. These results imply that the impact of multimorbidity on functional limitation and quality of life may vary across the life course.
CONCLUSION
Using novel methodological techniques, this study contributes to a better understanding of the longitudinal relationship between functional limitation and quality of life among individuals with and without multimorbidity and how this relationship changes across the life course. Our findings suggest that lowering the risk of having multimorbidity can decrease functional limitation and increase quality of life
Evaluating Registered Reports with P-curves
No full textResearch project on Registered Reports, aiming to evaluate their evidential value with the help of p curves. Is the evidential value from Registered better than from regular publications
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