1,721,200 research outputs found
Graphene in Regenerative Medicine: Focus on Stem Cells and Neuronal Differentiation
No full textEmerging graphene-based materials offer numerous opportunities to design novel scaffolds for neural tissue engineering. Graphene is a promising candidate due to its superior topographical, chemical, and electrical cues compared with conventional biomaterials. Here we examine the state of the art in graphene-based materials science for the neurodifferentiation of stem cells
Clinical evidence and therapeutic treatments at the time of the coronaviruses responsible for SARS: a perspective point of view
Full text linkThe clinical evolution of the COVID-19 patients highlights a significant minority of subjects with very rapid lethal outcomes with respect to the almost complete healing after coronavirus infections for most of the subjects involved. In addition, the reckless use of some drugs and therapeutic protocols that have not shown any efficacy in reducing mortality in those patients where the progression of the disease was unstoppable suggests a different interpretative way in the pathogenesis of severe cases. Starting from the 19 clinical data already known for almost twenty years on the behavior of human SARS coronaviruses it is possible to advance a new hypothesis. The reference points taken into consideration are: i) the comparison of the histological evidence of the autoptic material; ii) the poor pharmacological response in subjects with severe phenotype of the pathology; iii) the common elements of endotheliitis that a subgroup of the population characterized by the unfortunate clinical outcome expresses during the evolution of the pathology. The tendency to develop a widespread, massive endothelial lesions not responding to any drug therapy or health treatment necessarily play a crucial role in the onset of the systemic and severe stage of the disease. The present hypothesis opens the door to a different therapeutic approach both to the full-blown phase of COVID-19 and to the preventive phase or the very first manifestations of the disease, suggesting greater attention to the protection of the vascular endothelium in subjects who already have it predisposed to the severe evolution of this ailment than to simple antiviral defense
Clinical evidence and therapeutic treatments at the time of the coronaviruses responsible for SARS: a perspective and points of view with a focus on vascular endothelium
No full textThe clinical outcomes of COVID-19 patients highlight a significant minority of subjects with very rapid lethal outcomes subsequent to the almost complete healing after coronavirus infections for most of the subjects involved. In addition, the reckless use of some drugs and therapeutic protocols that have not shown any efficacy in reducing mortality in those patients where the progression of the disease was unstoppable suggests a different interpretative model in the pathogenesis of severe cases. Starting from the clinical data already known for almost twenty years on the behavior of human SARS coronaviruses it is possible to advance a new hypothesis. The reference points taken into consideration are: i) the comparison of the histological evidence of the autoptic material; ii) the poor pharmacological response in subjects with severe phenotypes of the pathology; iii) the common element of endotheliitis in a subgroup of the population characterized by harmful clinical outcomes during the evolution of the pathology. The tendency to develop widespread, massive endothelial lesions not responding to any drug therapy or other interventions necessarily play a crucial role in the onset of the systemic and severe stage of the disease. The present perspective opens the door to a different therapeutic approach both to the full-blown phase of COVID-19 and to the preventive phase or the very first manifestations of the disease. It is imperative to pay more attention to the protection of the vascular endothelium in subjects who already have a predisposition to the development of a severe evolution of this ailment rather than to give a simple antiviral therapy together with symptomatic drugs
Studio preliminare sull’impiego di una protesi riassorbibile di acido ialuronico per la rigenerazione in vivo di una vena di piccolo diametro
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