105,067 research outputs found

    La Nature a-t-elle une fin? Le problème de la téléologie chez Kant

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    Zanetti V. La Nature a-t-elle une fin? Le problème de la téléologie chez Kant. Bruxelles: Ousia; 1994

    [Andy Zanetti, 2003]

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    Photograph of Andy Zanetti standing with his arms crossed in front of a shrub. Zanetti wears a wristwatch and a t-shirt with the phrase "How Wash Your Genes" printed on it. Large trees grow in front of a brick house beyond the shrub

    Esperienze

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    Probing the role of lysine 116 and lysine 244 in the spinach ferredoxin-NADP+ reductase by site-directed mutagenesis

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    Two mutants of the spinach ferredoxin-NADP+ reductase (FNR) were constructed, expressed by using a heterologous expression system previously described (Aliverti, A., Jansen, T., Zanetti, G., Ronchi, S., Herrmann, R. G., and Curti, B. (1990) Eur. J. Biochem. 191, 551-555), and purified to homogeneity. The mutant enzymes FNR-Lys116Gln and FNR-Lys244Gln were similar to the wild-type enzyme in the physicochemical properties measured; however, both enzymes showed a lower activity. Steady-state kinetic analyses and NADP+ binding measurements of the mutant proteins have revealed that the Lys116Gln enzyme had a catalytic efficiency (kcat/KmNADPH) 500-fold lower than that of the wild-type enzyme, and its interaction with NADP+ was greatly impaired. The Lys244Gln enzyme instead had almost the same kcat in the ferricyanide reductase reaction as the wild-type enzyme, while higher values of KmNADPH and Kd for NADP+ were observed. Thus, protein engineering has enabled us to define the role of Lys-116 and Lys-244 in ferredoxin-NADP+ reductase; whereas Lys-244 contributes to the stabilization of the Michaelis complex, the Lys-116 side chain plays an important role also in the further steps of the catalytic cycle, because both Km and kcat are highly affected by the mutation

    Forecasting banknotes

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    A central bank’s liquidity forecast is important in ensuring that it supplies the banking system’s need for central bank money. Banknote (or currency in circulation) demand is the largest and for some central banks the most variable component of the liquidity forecast. Accurate forecasting of banknotes is essential in ensuring an accurate liquidity forecast and in turn effective monetary policy implementation. This Handbook discusses these issues and outlines a structural time series state space (STSSS) model which is now used by central banks including the Bank of England and ECB to forecast banknotes (currency in circulation).Forecasting banknotes

    Editoriale. Concordia e conflitto

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    Editoriale alla sezione monografica "Concordia" di «Filosofia Politica» (https://www.rivisteweb.it/doi/10.1416/89148

    Tetartopeus ciceronii ZANETTI 1998

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    <i>Tetartopeus ciceronii</i> ZANETTI, 1998 <p> Comment: In a recent paper, BORDONI (2013) proposed several, partly rather bizarre synonymies, among them the (repeated) synonymy of <i>T. ciceronii</i> with <i>T. rufonitidus</i> REITTER (1909), without providing any new evidence whatsoever. As argued in detail earlier (ASSING 2008), <i>T. ciceroni</i> undoubtedly represents a distinct species differing from <i>T. rufonitidus</i> in numerous constant characters and is consequently revalidated.</p>Published as part of <i>Assing, V., 2014, A revision of Tetartopeus IV. A new species from Turkey, new synonymies, and additional records (Coleoptera: Staphylinidae: Paederinae), pp. 1119-1131 in Linzer biologische Beiträge 46 (2)</i> on page 1121, DOI: <a href="http://zenodo.org/record/5307283">10.5281/zenodo.5307283</a&gt

    Omalium schuberti ZANETTI 2002

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    <i>Omalium schuberti</i> ZANETTI, 2002 <p>M a t e r i a l e x a m i n e d: Israel: 3, 1, Har Hermon, 33°18'N, 35°46'E, 1780 m, S-slope, pitfall, 2.IV.2011, leg. Drees (cAss); 1, Har Hermon, 33°18'N, 35°47'E, 2000 m, doline, pitfall, 13.XI.2010, leg. Drees (cAss).</p> <p> C o m m e n t: The previously known distribution of <i>O. schuberti</i> was confined to Turkey, where this species is widespread but rather uncommon (ASSING 2009a, 2013a; ZANETTI 2002). The above specimens represent the first records from Israel.</p>Published as part of <i>Assing, V., 2014, On the Staphylinidae of Israel II, with a revision of some species of Dinusa SAULCY (Insecta: Coleoptera), pp. 1179-1210 in Linzer biologische Beiträge 46 (2)</i> on page 1181, DOI: <a href="http://zenodo.org/record/5308301">10.5281/zenodo.5308301</a&gt
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