86,527 research outputs found
[Minimal Change Relapse During Pregnancy]
No full textThe appearance of nephrotic syndrome during pregnancy is considered an exceptional event, whose incidence is around 0.012-0.025% of all pregnancies, and it is even more rare when the cause is represented by minimal lesions glomerulonephritis. In this article we will describe the case of a patient with a histological diagnosis of glomerulonephritis with minimal lesions, tending to frequent relapses. She was in complete remission since 2013 after treatment with cyclosporine. suspended in May 2017. After few weeks she become pregnant, and the pregnancy was regular until the 23rd week. when a recurrence of nephrotic syndrome appears. She was treated with steroids bolus followed by oral steroid, and afterwards gave birth to a live fetus with spontaneous delivery at 37 weeks The few data in the literature confirm that recurrence of glomerulonephritis due to minimal lesions in pregnancy should be treated rapidly with steroids, that can induce rapid remission and protect both the pregnant than the fetus from even serious damag
Sindrome emolitico uremica atipica secondaria a chemioterapia con Oxaliplatino responsiva a Eculizumab
No full textDescriviamo il caso di una paziente affetta da adenocarcinoma del colon trattata con FOLFOX-4 (5-Fluorouracile, Acido Folinico, Oxaliplatino), con successiva comparsa di sindrome emolitico uremica atipica.
Sono presenti in letteratura dal 1999 al 2009 13 casi di SEU atipica in corso di chemioterapia con Oxali- platino, e sono stati descritti alcuni casi sporadici. Nessuno di questi è stato trattato con Eculizumab.
Il caso che illustriamo è il primo di SEUa secondaria a Oxaliplatino trattato con Eculizumab descritto in letteratura. Il trattamento ha indotto una completa remissione della sindrome, ed è stata possibile la di- scontinuazione del trattamento stesso.
Nel caso esposto sono state individuate mutazioni genetiche (una variante p.Asp98Asn del gene THBD in eterozigosi, di incerto significato patogenetico in presenza dell’aplotipo a rischio CFH-H3 in omozigosi) che potrebbero avere un ruolo patogenetico nell’istituzione della SEUa in concomitanza con l’esposizione a Oxaliplatino, che potrebbe agire come trigger.
L’identificazione dell’Oxaliplatino come fattore trigger nella SEUa e la sua discontinuazione hanno con- sentito alla paziente la prosecuzione di un diverso trattamento chemioterapico di I linea con pari aspet- tativa di vita e periodo libero da sintomi
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
New Mutation of CYP24A1 in a Case of Idiopathic Infantile Hypercalcemia Diagnosed in Adulthood
No full textBackground Since primary membranous nephropathy is a heterogeneous disease with variable outcomes and multiple
possible therapeutic approaches, all 13 Nephrology Units of the Italian region Emilia Romagna decided to analyze their
experience in the management of this challenging glomerular disease.
Methods We retrospectively studied 205 consecutive adult patients affected by biopsy-proven primary membranous nephropathy,
recruited from January 2010 through December 2017. The primary outcome was patient and renal survival. The secondary
outcome was the rate of complete remission and partial remission of proteinuria. Relapse incidence, treatment patterns
and adverse events were also assessed.
Results Median (IQR) follow-up was 36 (24–60) months. Overall patient and renal survival were 87.4% after 5 years. At the
end of follow-up, 83 patients (40%) had complete remission and 72 patients (35%) had partial remission. Among responders,
less than a quarter (23%) relapsed. Most patients (83%) underwent immunosuppressive therapy within 6 months of biopsy.
A cyclic regimen of corticosteroid and cytotoxic agents was the most commonly used treatment schedule (63%), followed
by rituximab (28%). Multivariable analysis showed that the cyclic regimen significantly correlates with complete remission
(odds ratio 0.26; 95% CI 0.08–0.79) when compared to rituximab (p < 0.05).
Conclusions In our large study, both short- and long-term outcomes were positive and consistent with those published in
the literature. Our data suggest that the use of immunosuppressive therapy within the first 6 months after biopsy appear
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
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