86,676 research outputs found
Patologie gonadiche femminili: Iperandrogenismi e irsutismi, Sindrome ovaio policistico,Menopausa.
No full textNO ABSTRAC
A standardized framework for testing the performance of sleep-tracking technology: step-by-step guidelines and open-source code
No full textSleep-tracking devices, particularly within the consumer sleep technology (CST) space, are increasingly used in both research and clinical settings, providing new opportunities for large-scale data collection in highly ecological conditions. Due to the fast pace of the CST industry combined with the lack of a standardized framework to evaluate the performance of sleep trackers, their accuracy and reliability in measuring sleep remains largely unknown. Here, we provide a step-by-step analytical framework for evaluating the performance of sleep trackers (including standard actigraphy), as compared with gold-standard polysomnography (PSG) or other reference methods. The analytical guidelines are based on recent recommendations for evaluating and using CST from our group and others (de Zambotti and colleagues; Depner and colleagues), and include raw data organization as well as critical analytical procedures, including discrepancy analysis, Bland-Altman plots, and epoch-by-epoch analysis. Analytical steps are accompanied by open-source R functions (depicted at https://sri-human-sleep.github.io/sleep-trackers-performance/AnalyticalPipeline_v1.0.0.html). In addition, an empirical sample dataset is used to describe and discuss the main outcomes of the proposed pipeline. The guidelines and the accompanying functions are aimed at standardizing the testing of CSTs performance, to not only increase the replicability of validation studies, but also to provide ready-to-use tools to researchers and clinicians. All in all, this work can help to increase the efficiency, interpretation, and quality of validation studies, and to improve the informed adoption of CST in research and clinical settings
Selective effect of a maize diet in reducing serum and brain tryptophan contents and blood and brain serotonin levels
No full textThe Maize diet used selectively lowers the tryptophan, serotonin and 5-hydroxyindoleacetic acid levels in the central nervous system without affecting catecholamine content. These changes are maximal as early as 48 hours after exposure to the Maize diet. The brain serotonin decrease is reversed to normal when the Maize diet is supplemented with Tryptophan, while nicotinic acid is ineffective. The maize diet seems to be a rapid and selective means of reducing brain serotonin content. The hypothesis that the psychic depression observed in patients with Pellagra may be related to an altered serotonin metabolism is discussed
Modifications of DOPAC levels in the striatum and olfactory tubercles of the rat after muscimol
No full textWhen muscimol was injected intraventricularly or intraperitoneally to rats at the dose of 0.6 μg/ventricle and 4 mg/kg, respectively, dihydroxyphenylacetic acid (DOPAC) levels, determined by a radioenzymatic method, were statistically increased in a qualitative similar way in the striatum and olfactory tubercles after both routes of administration. The results, in agreement with other Authors' findings, support the hypothesis of a stimulation of dopamine turnover by muscimol
Muscimol antagonism of morphine analgesia in rats
No full text1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia
Nipecotic acid and guvacine antagonism on morphine analgesia in rats
No full textIn the attempt to further characterize the role of the GABA-ergic system on morphine analgesia, nipecotic acid and guvacine, inhibitors of GABA reuptake, were administered intraventricularly in rats pretreated with morphine. Under these conditions the animals showed a decreased response to the antinociceptive effect of morphine when compared to control rats
The effect of GABAergic agents on opiate analgesia
No full textThe present study shows that the intraventricular injection of muscimol (250 ng/ventricle), a potent GABA receptor agonist, strongly antagonized morphine and β-endorphin analgesia. Furthermore, isoguvacine, a compound structurally related to muscimol, and nipecotic acid and guvacine, inhibitors of GABA uptake, administered intraventricularly markedly attenuated the analgesic effect of morphine. These results further substantiate that the GABAergic system is involved in morphine analgesia. A possible mechanism of action is discussed
Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats
No full textIntracerebroventricular administration of muscimol, a potent GABA-receptor agonist, counteracted the antinociceptive effect of morphine or beta-endorphin in rats as measured by the "tail flick" method. Muscimol's activity was reversed by bicuculline. Isoguvacine, another GABA agonist, as well as nipecotic acid and guvacine, two inhibitors of neuronal and glial uptake of GABA, also antagonized morphine's antinociceptive effect. A role of the central GABA-ergic system in mediating opiate antinociception is proposed
TRIGEMINAL TROPHIC SYNDROME: STRANGE EVOLUTION OF MAXILLOFACIAL SURGERY
No full textTrigeminal trophic syndrome (TTS) is a rare facial/cranial affection that arises in ulcerations, itch and paresthesia. Etiology is debated, however trigeminal nerve damage seems to be frequent in pathogenetic patterns. The disease may affect any region innervated by the trigeminal nerve, especially the maxillary branch. A case of TTS, trigged by allergic reaction to osteosynthetic materials and involving infraorbital nerve, was presented. The feature that makes this case one-off in the literature is the association with osteolytic lesion surrounding infraorbital nerve. Diagnosis and treatment were difficult and multidisciplinary approach was required. Treatments administered were satisfying and signs and symptoms remitted, however patient quitted follow-up. TTS is a rare disease, diagnosis is difficult to be performed and it is often a diagnosis of exclusion. Treatment is challenging and it requires a multidisciplinary approach and a great compliance of patients
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