17 research outputs found
Ritsa' اتجاهات إبراهيم بن المهدي في قصيدته الرثاء
No full textAbstract: This article aims to know the Ittijahat of Ibrahim Bin Al-Mahdy in his poem of Ritsa’. Ittijahat in this study is a description of the poet's tendency to divide Ritsa'. Ritsa is one of the various forms of Arabic poetry. To analyze the discussion problem, the author uses the descriptive analysis method, because this method is very appropriate to find out the picture and state of a thing by describing it in as much detail as possible based on the facts found in the data in question. The results obtained are: That Ritsa’ Ibrahim Bin Al-Mahdy varied in two directions namely, Nadb and Ta’bin. In the first direction, the poet tended to mourn his eldest son, where he showed a lot of sorrow, grief, and crying after his son went to the afterlife. Whereas in the second direction, the poet tended to eulogize his strength and highlight his heroism and masculinity, this arose because he was surprised by the sudden death of his son due to illness.
Keywords: Ritsa’, Ittijahat, Nadb, Ta’bin</jats:p
Editorial Expression of Concern: Prevalence and risk factors for female sexual dysfunction among Egyptian women
No full textRole of 1,25-dihydroxyvitamin D (vitamin D3) as immunomodulator in recurrent missed miscarriage
No full textObjective: To evaluate the immunomodulatory role of vitamin D3 in prevention of pregnancy loss in cases of recurrent miscarriage.
Patients and methods: A total of 40 pregnant women with gestational age at or less than 6 weeks with recurrent miscarriage were enrolled in the present study and randomly assigned to study and control group each (n = 20 for each group) after fulfilling certain inclusion and exclusion criteria. All participants were assessed through complete history, general and obstetric history, ultrasound assessment and routine full laboratory evaluation. IFN-γ was assessed at ⩽6 week gestation on recruitment, then after treatment every 2 weeks till 14th week for both groups. Both groups received standard measures for cases with recurrent miscarriage. Study group participants were treated with oral vitamin D3 supplementation. Outcome measures included continuing pregnancy rate and change in INF-γ values between first and final assays.
Results: No statistically significant difference was noted between both groups regarding baseline demographic, clinical characteristics and ultrasonographic findings. Control group participants were found to have significantly higher levels of IFN-γ compared to the study group after treatment. Risk of miscarriage was 15% lower among the study group than the control group. Continuing pregnancy rate was 70% in the study group and 55% in the control group. No significant difference was found between both groups regarding symptoms suggesting vitamin D3 side effects.
Conclusion: Although statistically insignificant, vitamin D3 oral supplementation has resulted in reducing risk of pregnancy loss up to 15% among women with recurrent miscarriage so it is a matter that is worth more attention and large scale studies with larger sample size may result in more significant results
Micro-dose flare-up gonadotrophin-releasing hormone (GnRH) agonist vs. flexible gonadotrophin-releasing hormone (GnRH) antagonist protocol in patient with poor ovarian reserve
No full textObjective: To compare the efficacy of two methods of ovarian stimulation, namely micro-dose flare-up gonadotrophin-releasing hormone (GnRH) agonist protocol and flexible gonadotrophin-releasing hormone (GnRH) antagonist protocol in patients with poor ovarian reserve.
Design: A prospective, randomized, double blind clinical trial.
Setting: Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Infertility Clinic, Ismailia, Egypt, Private Center, Cairo, Egypt, December 2006–May 2008.
Patient(s): Fifty-nine patients with poor ovarian responses based on the following criteria ovarian volume 8 IU/l (29) undergoing IVF/ICSI treatment. Exclusion criteria: (1) any other cause of infertility other than poor ovarian reserve; (2) refusal of the patient to be enrolled to the study.
Intervention(s): All women were prospectively randomized into two groups by computer-assisted randomization. The patients in group 1 were stimulated according to the micro-dose flare-up protocol (n = 30), while the patients in group 2 were stimulated according to flexible antagonist protocol (n = 29).
Main outcome measure(s): The mean number of oocytes retrieved was the primary outcome measure, number of mature oocytes retrieved, number of fertilized oocytes, number of embryos transferred, stimulation duration (days), total dose of gonadotrophin IU, estradiol concentration on the day of hCG administration, fertilization rate, implantation rate, ongoing pregnancy rate were secondary outcome measures, cancellation rate.
Result(s): The use of flexible GnRH antagonist protocol ended with significantly less gonadotrophin requirements (2831.9 ± 623.02 vs. 3187.5 ± 704.04; p = 0.04) and a shorter duration of stimulation (9.6 ± 2.02 vs. 10.8 ± 2.4 days; p = 0.04). The fertilization rate (77.3% vs. 68.5), implantation rate (12.2% vs. 8.9%), and ongoing pregnancy rate (20.8% vs. 12.5%) were higher in the antagonist group but did not achieve statistical significance. The cancellation rate was higher in the agonist group (20% vs. 17.2%) but the difference was not statistically significant. The numbers of oocytes retrieved, mature oocytes, fertilized oocytes, embryo transfer, and the estradiol concentration on the day of hCG were not significantly different between the two groups compared.
Conclusion(s): The role of flexile GnRH antagonist in women with poor ovarian reserves appear to be promising and further randomized clinical trials are needed
Methylenetetrahydrofolate C677T polymorphism and pre-eclamptic Egyptian women
No full textThrombosis of the maternal spiral arteries can be one of the causative events in pre-eclampsia disease, it has been suggested that the C677T polymorphism may also play a role in the pathogenesis of pre-eclampsia.
Aims of the work: To investigate the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in Egyptian pregnant women’s with pre eclampsia, and compare with the control group.
Type of study: A prospective comparative study among two groups of subjects: 44 preeclamptic women and 44 women with normal pregnancies from November 2008 to April 2010, at Suez Canal University, Faculty of Medicine, Obstetrics and Gynecology Department, DNA was amplified by polymerase chain reaction with sequences specific primers (SSP-PCR). DNA purification capture column kit (Gentra system, USA). Digestion was performed by restrictasc Hinf1 (Fermentas), visualization of genomic DNA by minigel electrophoresis primer sequences. The gels were then photographed under UV light (320 nm) and scored for the presence or absence of an allele specific band.
Results: The study group had a significantly higher frequency of the homozygous mutated TT allele (34.1% vs. 0.0%, P < 0.0001) and T Allele genotype of C677T polymorphisms compared to controls, (56.8% vs. 31.8%) in both groups respectively and significant OR (46.76).
The control group had a higher frequency of both the heterozygous mutated CT and homozygous CC genotypes of C677T polymorphism than the other groups (P < 0.0004)
Conclusion: C677T polymorphism of MTHFR gene was found to be associated with the development of pre-eclampsia. Mutant T allele and TT genotypes of C677T may be considered genetic risk factors for the development of pre-eclampsia among Egyptian pregnant women
Use of the Foley catheter versus a double balloon cervical ripening catheter in pre‐induction cervical ripening in postdate primigravidae
No full textEffect of di(n- butyl) phthalate on the blood–testis barrier during puberty onset
No full textDATA AVAILABILITY : The data that support the findings of this study are available from the corresponding author upon reasonable request.Di(n-butyl) phthalate (DBP) is considered a substance of serious concern because of its reproductive toxicity and endocrine-disrupting properties. Exposure to DBP causes morphological and functional changes in the male reproductive system of birds and mammals. However, there are no detailed reports on the effects of DBP on the Sertoli cell and junctional complexes of the blood–testis barrier (BTB) in birds. The present study investigated dose-related ultrastructural changes in Sertoli cells and junctional complexes of the BTB in adult Japanese quail (Coturnix coturnix japonica) exposed to DBP prior to puberty. A total of 25 Japanese quail were used for the study. Exposure to DBP doses of 50, 200 and 400 mg DBP/kg/d caused dose-related ultrastructural changes in junctional complexes including dilation and separation, while disruption of cytoplasmic membranes and mitochondria was observed in Sertoli cells. There was a significant difference in the sum of vacuoles, vacuole diameter, nuclear width, nuclear length, nuclear area, sum of damaged spherical mitochondria, width of elongated mitochondria and the sum of damaged elongated mitochondria among the five treatment groups (p ˂ 0.05). Prepubertal exposure to DBP at doses of 50, 200 and 400 mg DBP/kg/d for 30 days led to adverse effects in the adult male Japanese quail reproductive system by inducing structural changes in the Sertoli cells and junctional complexes. Such changes might disrupt the BTB and potentially interfere with spermatogenesis. Results indicated that the Sertoli cell is sensitive to DBP exposure and might be an important cellular target for DBP-induced testicular toxicity.The National Research Foundation.http://wileyonlinelibrary.com/journal/ahe2024-01-06Anatomy and PhysiologyParaclinical SciencesProduction Animal Studie
Author Correction: Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries (Nature Medicine, (2025), 10.1038/s41591-024-03345-4)
No full textCorrection to: Nature Medicinehttps://doi.org/10.1038/s41591-024-03345-4, published online 6 January 2025. In the version of the article initially published, in the eighth paragraph of the Discussion, the text “Among large nations, the largest increases in SSB-related T2D burdens were in Mexico, Thailand and the United Kingdom, and in CVD burdens, Colombia, Nigeria, Thailand and Russia. These changes align with rises in SSB consumption in these nations12. Similarly, declining SSB-related cardiometabolic burdens in Brazil, the United States and the United Kingdom (for CVD) are consistent with their decreasing SSB consumption from 1990 to 202012” was incorrect and has now been updated to “Among largely populated nations, the largest increases in SSB-related T2D incidence was in Colombia, USA and Argentina; and in CVD incidence, Nigeria, Russia, Colombia and Thailand. These changes generally align with rises in SSB consumption in these nations, except in the US where slight declines in SSB consumption were offset by increased burdens of diabetes 12. Similarly, declining SSB-related cardiometabolic burdens in Turkey, Brazil, and the United States and the United Kingdom for CVD are consistent with their decreasing SSB consumption from 1990 to 202012.” Additionally, Supplementary Data 1 and 2 have been updated to remove decimals in values greater than 100. These corrections have been made to the HTML and PDF versions of the article. © The Author(s) 2025
In vitro assessment of the antimicrobial activity of silver and zinc oxide nanoparticles against fish pathogens
No full textBackground: Antibiotic resistance is a global issue that threatens public health. The excessive use of antibiotics contributes to this problem as the genes of antibiotic resistance can be transferred between the bacteria in humans, animals and aquatic organisms. Metallic nanoparticles could serve as future substitutes for some conventional antibiotics because of their antimicrobial activity. The aim of this study was to evaluate the antimicrobial effects of silver and zinc oxide nanoparticles against major fish pathogens and assess their safety in vitro. Silver nanoparticles were synthesized by chemical reduction and characterized with UV–Vis spectroscopy, transmission electron microscopy and zeta sizer. The concentrations of silver and zinc oxide nanoparticles were measured using inductively coupled plasma-mass spectrometry. Subsequently, silver and zinc oxide nanoparticles were tested for their antimicrobial activity against Aeromonas hydrophila, Aeromonas salmonicida subsp. salmonicida, Edwardsiella ictaluri, Edwardsiella tarda, Francisella noatunensis subsp. orientalis, Yersinia ruckeri and Aphanomyces invadans and the minimum inhibitory concentrations were determined. MTT assay was performed on eel kidney cell line (EK-1) to determine the cell viability after incubation with nanoparticles. The interaction between silver nanoparticles and A. salmonicida was investigated by transmission electron microscopy.
Results: The tested nanoparticles exhibited marked antimicrobial activity. Silver nanoparticles inhibited the growth of both A. salmonicida and A. invadans at a concentration of 17 µg/mL. Zinc oxide nanoparticles inhibited the growth of A. salmonicida, Y. ruckeri and A. invadans at concentrations of 15.75, 31.5 and 3.15 µg/mL respectively. Silver nanoparticles showed higher cell viability when compared to zinc oxide nanoparticles in the MTT assay. Transmission electron microscopy showed the attachment of silver nanoparticles to the bacterial membrane and disruption of its integrity.
Conclusions: This is the first study on inhibitory effects of silver and zinc oxide nanoparticles towards A. salmonicida and A. invadans. Moreover, zinc oxide nanoparticles inhibited the growth of Y. ruckeri. In low concentrations, silver nanoparticles were less cytotoxic than zinc oxide nanoparticles and represent an alternative antimicrobial compound against A. hydrophila, A. salmonicida and A. invadans.© The Author(s) 201
