4 research outputs found
A CLINICAL STUDY OF NEUROFIBROMATOSIS WITH A SPECIAL REFERENCE TO CUTANEOUS MANIFESTATIONS
No full textCLINICAL PROFILE OF PATIENTS WITH CHRONIC DERMATOPHYTOSIS- A DESCRIPTIVE STUDY FROM A TERTIARY CARE CENTRE IN KERALA
No full textPrescription pattern of topical corticosteroids in dermatology department in a tertiary care hospital
No full textBackground: Topical steroids are sometimes combined with other active ingredients including antibacterial agents, antifungal agents and calcipotriol. The study of prescription pattern measures the performance of health care providers in several key dimensions related to the appropriate use of drugs. The objectives of the study were to study the prescription pattern of topical corticosteroids in terms of indications, its potency, average number of topical corticosteroids per patient and in fixed dose combinations.
Methods: Data of patients prescribed with topical corticosteroids in dermatology department OPD were collected. Data included age, gender, clinical diagnosis, topical & systemic corticosteroids prescribed and their dosing schedule
Results: Out of 500 cases, 229 were males and 271 were females. Mean age of patients was 40.60±19.789 years. Most common dermatological condition for topical corticosteroid prescription was dermatitis (43.8%). 45. 9% of prescribed corticosteroids were moderate potent agents. Average number of topical corticosteroids per prescription was 1.04. Most commonly prescribed topical corticosteroids were betamethasone dipropionate. Most common dosage form was cream. Most common fixed dose combination was with gentamicin. Among 103 fixed dose combinations 42.7% were combined with moderately potent steroids. 72% drugs were prescribed in generic name. 4% of prescription had strength of steroids mentioned. 80% of prescription stated site of application and in 76% cases frequency of drug application was mentioned. Duration of treatment was mentioned in 86.4% of cases.
Conclusions: Study demonstrates variability of topical corticosteroid utilization in various dermatological conditions
CLINICAL STUDY OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) – WITH SPECIAL FOCUS ON THE INCITING DRUG AND THE INDICATION FOR STARTING THE DRUG
No full textObjective: This study was undertaken to identify the most common drug causing drug reaction with eosinophilia and systemic symptoms (DRESS) inpatients admitted in our center and possible factors associated with it.
Methods: This was a cross-sectional observational study of patients with DRESS admitted from January 2018 to December 2020. Data were entered in MS Excel and analyzed using SPSS software.
Results: Eighty-four consecutive patients who were diagnosed as DRESS were included in the study. The most common inciting drug was phenytoin and the most common indication for starting phenytoin was traumatic brain injury (TBI) to prevent seizures. DRESS to phenytoin after neurotrauma (NT) was more in patients who sustained combined extradural (EDH) and subdural hematoma (SDH), and those were managed conservatively for NT. None of the patients recognized fever as an initial feature of DRESS and did not stop the drug. More than one-third of patients with erythema multiforme (EM) like rash developed drug induced liver injury(DILI). The majority of patients who had sub-arachnoid hemorrhage (SAH) developed DILI.
Conclusion: Phenytoin though time-tested and cost-effective for prevention of seizures after TBI, it very commonly leads to DRESS which adds to the morbidity and rarely mortality of patient. In this present era of increasing road traffic accidents, using newer non-aromatic anticonvulsants may be more beneficial than phenytoin. The patients should be made aware of the likely time DRESS can occur, the earliest symptom of DRESS, and the need to stop the drug at the earliest
