1,721,268 research outputs found
Apoptosis in mouse skeletal muscles after physical exercise.
No full textApoptosis in mouse skeletal muscles after physical exercise.
Podhorska-Okołów M, Krajewska B, Carraro U, Zabel M.
Folia Histochem Cytobiol. 1999;37(2):127-8. No abstract available.
PMID:
10352991
[PubMed - indexed for MEDLINE
Information provided by home monitoring is highly predictive for the necessity of therapeutic measures in ICD patients
No full textInformation provided by home monitoring is highly predictive for the necessity of therapeutic measures in ICD patients
No full text
Exercise-induced apoptosis in rat kidney is mediated by both angiotensin II AT1 and AT2 receptors
No full textHistol Histopathol. 2006 May;21(5):459-66.
Exercise-induced apoptosis in rat kidney is mediated by both angiotensin II AT1 and AT2 receptors.
Podhorska-Okolow M, Dziegiel P, Gomulkiewicz A, Kisiela D, Dolinska-Krajewska B, Jethon Z, Carraro U, Zabel M.
Source
Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland. [email protected]
Abstract
Excessive physical exercise may lead to disturbance of the entire homeostasis in the body, including damage not only in skeletal muscles but also in many distant organs. The mechanisms responsible for the exercise-induced changes could include oxidative stress or angiotensin II. We previously showed that acute exercise led to apoptosis in kidney but not as a result of oxidative stress. In this study, we examined the role of angiotensin II and its AT1 and AT2 receptors in mediation of exercise-induced apoptosis in kidney. We clearly demonstrated that acute physical exercise induced apoptosis in renal cells of distal convoluted tubuli and cortical and medullary collecting ducts. Moreover, the cells displayed an increased expression of both AT1 and AT2 angiotensin II receptors and of p53 protein. The results suggest that angiotensin II could upregulate p53 expression in renal distal convoluted tubular cells and in the cells collecting ducts via both AT1 and AT2 receptors, which might be the crucial apoptosis-mediating mechanism in kidneys after excessive exercise.
PMID:
16493576
[PubMed - indexed for MEDLINE
Comparison of single-lead ICD system capable of atrial sensing (A plus ICD) and a DDD-ICD system in patients without antibradycardia pacing indications
No full text
Role of coronary angiography before radiofrequency ablation in patients presenting with paroxysmal supraventricular tachycardia
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