102,846 research outputs found
F. Nietzsche, Crepuscolo degli idoli.
No full textTrad. ital. di Cristina Zuin; introduzione, commentario e bibliografia di Giorgio Brianese. Testo originale a fronte
Su un casi di occlusione portale preepatica associato a parziale occlusione dell'arteria epatica
No full textOptimal Site for Proximal Optimization Technique in Complex Coronary Bifurcation Stenting: A Computational Fluid Dynamics Study
No full textBackground/purpose: The optimal position of the balloon distal radio-opaque marker during the post optimization technique (POT) remains debated. We analyzed three potential different balloon positions for the final POT in two different two-stenting techniques, to compare the hemodynamic effects in terms of wall shear stress (WSS) in patients with complex left main (LM) coronary bifurcation. Methods/materials: We reconstructed the patient-specific coronary bifurcation anatomy using the coronary computed tomography angiography (CCTA) data of 8 consecutive patients (6 males, mean age 68.2± 18.6 years) affected by complex LM bifurcation disease. Subsequently a virtual bench test was performed in each patient using two different double stenting techniques represented by the DK and Nano crush using the reconstruction of Orsiro stents (Biotronik IC, Bulack, Switzerland). Results: A significant reduction in the mean WSS values in all the lesion's sites was observed when the final POT was performed 1 mm distally the carina cut plane in both techniques. Moreover, a significant improvement in the mean WSS values of the entire SB (e.g. LCX) was obtained performing the POT 1 mm distally to the carina cut plane. The proximal POT resulted in larger area of lower WSS values at the carina using both the Nano crush and the DK crush techniques. Conclusions: In patients with complex LM bifurcation disease the use of a final POT performed 1 mm distally to the carina cut plane might results in more favorable WSS patterns (i.e. higher WSS values) along all stented segments and, especially, along the entire LCX lesions
La broncopneumopatia cronica ostruttiva
No full textLa broncopneumopatia cronica ostruttiva (BPCO) è una condizione clinica caratterizzata da una limitazione al flusso aereo che non è completamente reversibile. La limitazione al flusso aereo è di solito progressiva ed associata ad una anomala risposta infiammatoria dei polmoni all’inalazione di agenti, particelle o gas, nocivi. I principali sintomi della BPCO sono la tosse, l’espettorato e la dispnea 1Molte delle definizioni precedenti di BPCO comprendevano i termini “enfisema” e “bronchite cronica”, non più enfatizzati come singole entità nella definizione attuale. L’enfisema, o distruzione della superficie di scambio dei gas, è un termine anatomopatologico che descrive solo una delle numerose alterazioni strutturali in grado di causare la limitazione al flusso aereo caratteristica della BPCO. La bronchite cronica, o presenza di tosse ed espettorato cronici, è un termine clinico che non descrive l’aspetto funzionale della malattia, cioè la limitazione al flusso aereo.E’ importante sottolineare che, mentre nella maggior parte dei pazienti, i sintomi di bronchite cronica precedono lo sviluppo della limitazione al flusso aereo, in altri pazienti ci può essere un’importante limitazione al flusso aereo in assenza di sintomi di bronchite cronica. Infine, ci sono alcuni pazienti con tosse ed espettorato cronici che non sviluppano mai limitazione al flusso aereo. Queste osservazioni indicano che anche se la BPCO è in generale caratterizzata da peggioramento progressivo della limitazione al flusso aereo, in realtà la storia clinica della malattia può variare da individuo a individuo, e di questo bisogna tener conto nell’inquadramento clinico e terapeutico del singolo paziente.In questo capitolo la BPCO verrà trattata in esteso, dalla patogenesi alla terapi
Giant localized fibrous tumours of the pleura: Report of three subsequent cases
No full textLocalized fibrous tumours of the pleura (LFTP) represent clinical entities rarely encountered, especially in giant forms. We report of three cases of giant localized fibrous tumours of the pleura found last year in a short time. The patients underwent surgery by thoracotomy. All tumours arose from visceral pleura and were radically excised by a wedge resection of the lung. The patients discharged from the hospital after a short postoperative period without complications. Two of three giant localized fibrous tumours were classified as benign forms; in one case a malignant characteristic was found
Averaged strain energy density estimated rapidly from nodal displacements by coarse fe analyses: cracks under mixed mode loadings
No full textThe strain energy density (SED) averaged over a structural volume allows to assess the fracture and fatigue behaviour of cracked components under mixed-mode loadings. To rapidly estimate the averaged SED , two approaches have been previously proposed: (i) the direct approach; (ii) the peak stress method (PSM) and nodal stress (NS) approach. In this paper the nodal displacement (ND) approach is presented to rapidly estimate the averaged SED from the nodal displacements by FE analyses. This method combines the advantages of all previous approaches, i.e. the use of coarse meshes able to capture the contributions of both stress intensity factors (SIFs) and higher order terms, without requiring geometrical modelling of the control volume. To validate the method, cracked plates and cracked bars under mixed-mode loadings have been analysed. The averaged SED values estimated by the ND approach agree with those calculated by the direct approach, within a range of applicability
La previsione delle emergenze ed il controllo delle piante infestanti dei tappeti erbosi
No full text
Risk of incident pericarditis after coronavirus disease 2019 recovery: a systematic review and meta-analysis
No full textAIMS: Data regarding the risk of incident pericarditis in coronavirus disease 2019 (COVID-19) recovered patients are lacking. We determined the risk of incident pericarditis after COVID-19 infection by performing a systematic review and meta-analysis of available data. METHODS: Following the PRISMA guidelines, we searched MEDLINE and Scopus to locate all articles published up to 11 February 2023 reporting the risk of incident pericarditis in patients who had recovered from COVID-19 infection compared to noninfected patients (controls) defined as those who did not experience the disease over the same follow-up period. Pericarditis risk was evaluated using the Mantel-Haenszel random effects models with hazard ratio (HR) as the effect measure with 95% confidence interval (CI) while heterogeneity was assessed using Higgins I2 statistic. RESULTS: Overall, 16 412 495 patients (mean age 55.1 years, 76.8% males), of whom 1 225 715 had COVID-19 infection, were included. Over a mean follow-up of 9.6 months, pericarditis occurred in 3.40 (95% CI: 3.39-3.41) out of 1000 patients who survived COVID-19 infection compared with 0.82 (95% CI: 0.80-0.83) out of 1000 control patients. Recovered COVID-19 patients presented a higher risk of incident pericarditis (HR: 1.95, 95% CI: 1.56-2.43, I2 : 71.1%) compared with controls. Meta-regression analysis showed a significant direct relationship for the risk of incident pericarditis using HT ( P = 0.02) and male sex ( P = 0.02) as moderators, while an indirect association was observed when age ( P = 0.01) and the follow-up length ( P = 0.02) were adopted as moderating variables. CONCLUSIONS: Recovered COVID-19 patients have a higher risk of pericarditis compared with patients from the general population
Reduction of venous thromboembolic events in COVID-19 patients: Which role for IL-6 antagonists?
No full textNo abstract availabl
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