1,715 research outputs found
Ran liao min hua tai yang neng dian chi de guang pu xiang ying zeng qiang
No full textChang, Shuai = 染料敏化太陽能電池的光譜響應增強 / 常帥.Thesis Ph.D. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 125-130).Abstracts also in Chinese.Title from PDF title page (viewed on 02, November, 2016).Chang, Shuai = Ran liao min hua tai yang neng dian chi de guang pu xiang ying zeng qiang / Chang Shuai
Energy-Efficient Train Operation: Conclusions and Future Work
No full textThis chapter gives the basic conclusions about energy-efficient train operation covering energy-efficient train driving, energy-efficient train timetabling, regenerative braking, energy storage systems and power supply networks. Future work that will develop energy-efficient train operation further include the interaction of connected driver advisory systems (C-DAS) and automatic train operation (ATO) with railway traffic management systems, cooperative train control in platoons of virtually coupled trains, digital twin technology and particularly its application to power supply systems, and the interaction between the railway network with the electrical power grid and renewable energy generation.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and Plannin
Influence of pressure on stable carbon isotope ratio and production yield of coal-derived methane
No full textOn blowup techniques and the pluricomplex Green's function
No full textThe pluricomplex Green's functions on a compact K ahler manifold have been extensively studied over the past decades. Following and generalizing the blow up techniques in [PS12], we use pluripotential theory to show the existence and uniqueness of pluricomplex Green's functions with two types of prescribed singularities at a finite number of interior points.Ph.D.Includes bibliographical referencesby Shuai Jian
Shuai bian an wu zhi mo xing xia de yu zhou jie gou yan hua
No full textCheng, Dalong = 衰變暗物質模型下的宇宙結構演化 / 程大龍.Thesis Ph.D. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 105-115).Abstracts also in Chinese.Title from PDF title page (viewed on 26, October, 2016).Cheng, Dalong = Shuai bian an wu zhi mo xing xia de yu zhou jie gou yan hua / Cheng Dalong
Introduction to Energy-Efficient Train Operation
No full textRailway, as one of the most energy-efficient transport, plays an essential role in improving the world’s energy and environmental sustainability. Statistics about rail share of transport activities and the corresponding energy consumption will demonstrate the energy efficiency of railway and indicate the potential of developing railway transport. Therefore, this chapter will provide an overview of the railway's energy consumption and traffic volume shares. Statistics presented in this chapter show that railway energy consumption decreased in these decades while its transport volume kept stable, and the traffic volume share of the railway is extremely large in urban transport. To achieve the goal of carbon neutralization, the European Union and many countries have conducted research projects on railway energy conservation. The technologies developed in these projects include energy-efficient train driving, integrated timetabling, using regenerative braking energy, etc. A summary of these technologies is also given, along with their potential energy savings, which range from 1 to 25%. This book will analyse and illustrate the whole systems processes of train operation with optimisation solutions. The structure of the following chapters will be presented at the end.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and Plannin
Kinetic modeling the effects of primary migration, diffusion and waterwashing on Upper Paleozoic coal-derived gas at the center of Ordos Basin
No full textEasyDelta: A spreadsheet for kinetic modeling of the stable carbon isotope composition of natural gases
No full textAbstract 3143: <i>FBW7</i> mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation
No full textAbstract
Colorectal cancer (CRC), the second leading cause of cancer-related deaths in the US, has been treated with targeted therapies. However, the mechanisms of differential responses and resistance of CRCs to targeted therapies are not well understood. In this study, we found that genetic alterations of FBW7, an E3 ubiquitin ligase and a tumor suppressor frequently mutated in CRCs, contribute to resistance to targeted therapies. CRC cells containing FBW7 inactivating mutations are insensitive to clinically used multi-kinase inhibitors of RAS/RAF/MEK/ERK signaling, including regorafenib and sorafenib. In contrast, sensitivity to these agents is not affected by oncogenic mutations in KRAS, BRAF, PIK3CA, or p53. These cells are defective in apoptosis due to blocked degradation of Mcl-1, a pro-survival Bcl-2 family protein. Deleting FBW7 in FBW7-wild-type CRC cells abolishes Mcl-1 degradation and recapitulates the in vitro and in vivo drug resistance phenotypes of FBW7-mutant cells. CRC cells selected for regorafenib resistance have progressive enrichment of pre-existing FBW7 hotspot mutations, and are cross-resistant to other targeted drugs that induce Mcl-1 degradation. Furthermore, a selective Mcl-1 inhibitor restores regorafenib sensitivity in CRC cells with intrinsic or acquired resistance. Together, our results demonstrate FBW7 mutational status as a key genetic determinant of CRC response to targeted therapies, and Mcl-1 as an attractive therapeutic target.
Citation Format: Jingshan Tong, Shuai Tan, Fangdong Zou, Jian Yu, Lin Zhang. FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3143. doi:10.1158/1538-7445.AM2017-3143</jats:p
Zai yi wei jin na mi dong zhen lie shang de biao mian deng li zi ti ji yuan shuai jian shou ming de zhi jie liang du
No full textNg, Ka Ho = 在一維金納米洞陣列上的表面等離子體激元衰減壽命的直接量度 / 吳家豪.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 101-111).Abstracts also in Chinese.Title from PDF title page (viewed on 31, October, 2016).Ng, Ka Ho = Zai yi wei jin na mi dong zhen lie shang de biao mian deng li zi ti ji yuan shuai jian shou ming de zhi jie liang du / Wu Jiahao
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