1,721,017 research outputs found
Possible involvement of complement receptor 1 (CR1) polymorphisms in the pathogenesis of atherosclerosis.
No full textPossibile involvement of complement receptor 1 (CR1) polymorphisms in the pathogenesis of atherosclerosis.
No full textImplicazione del gene RAGE nell’estensione della lesione a livello coronarico in pazienti affetti da CAD
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Association between two polymorphisms in the HLA-G gene and angiographic coronaryartery disease
No full textAtherosclerosis and related complications still represent the major cause of morbidity and mortality in industrialized countries. Therefore, it is particularly important to investigate the molecules involved in cardiac inflammation. Evidence exists showing that the human leukocyte antigen-G (HLA-G) gene tissue expression and related protein physiological significance is influenced by two polymorphisms, rs16375 and rs1632933. In this study, allelic, genotypic and haplotypic frequencies of a 14-bp insertion/deletion (Ins/Del) (rs16375) and of rs1632933 polymorphisms of the HLA-G gene were investigated in 664 patients with coronary artery disease (CAD) and 345 matched controls by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis and real-time PCR. The frequency of the Ins/Ins genotype was significantly higher in patients with CAD compared to the controls (P=0.018). After analysis of confounding variables, the results showed that the homozygous Ins/Ins was significantly and independently associated with the presence of angiographic CAD (odds ratio 2.09, 95% confidence interval 1.10-4.02, P=0.03). Our data demonstrate a new risk factor for this multifactorial inflammatory disease
Inflammation and atherosclerosis:the role of TNF and TNF receptors polymorphisms in coronary artery disease
No full textDiversa estrinsecazione dell¿infiammazione nella Sindrome da Fatica Cronica (CFS), Sarcoidosi e Sclerosi Laterale Amiotrofica (SLA)
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