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Studies on solubility and dissolution rate of gemfibrozil after its complexation with cyclodextrins
No full textThe aim of the present work was to improve the physicochemical properties of Gem through cyclodextrin (-CD) or hydroxypropyl-cyclodextrin (HP-CD) interactions. Gemfibrozil water solubility and dissolution rate were increased by cyclodextrin complexation. The study has shown that complex formation, in 1:1 stoichiometric ratio,
was successfully obtained in aqueous solution while in
the solid state only very small interactions between drug and different cyclodextrins were revealed. The pH value, changing the ionization degree of drug molecule, influenced the complexation process, as indicated by different stability constant values obtained at various pH
Influence of the microwave technology on the physical-chemical properties of solid dispersion with Nimesulide
No full textThis work describes a new approach to prepare solvent-free solid dispersions (SDs) for Nimesulide (NMS), involving the use of microwaves irradiation (MW). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage form for the poorly soluble drug Nimesulide (NMS), employing Gelucire® 50/13 and Poloxamer 188 (Lutrol® F 68) as surfactant carriers. Their physicochemical characteristics and dissolution properties were compared to the corresponding physical mixtures and the drug alone. The results attested a correspondence of the solid state of the drug before and after the irradiation treatment and that an amorphisation form of the drug in SD systems was obtained. After six months this data was confirmed
Analysis of chlorcyclizine and related compounds by liquid chromatography for stability studies.
No full textPreparazione e caratterizzazione di compresse a rilascio sostenuto di fluoxetina cloridrato
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