1,721,044 research outputs found
Non-Chiral Pool Derived Synthetic Auxiliaries: Use of C2-Symmetric Chiral Diols
No full textSynthesis of enantiomerically pure compounds by the use of “man made” chiral inducers has the greatest potential for general asymmetric synthesis since, in principle, no limits exist in terms of their molecular design. This chapter covers the syntheses and uses of enantiopure 1,2- and 1,3-C2-symmetric diols as chiral inducers for diastereoselective reactions, as well as the prepa-ration and applications of the axially chiral 1,1′ binaphthalene-2,2′-diol (BINOL) structure and its derivatives. The interest for these “privileged ligands” is due to their peculiar steric and electronic properties, able to drive the stereochemical course of important chemical reactions in high levels of enantioselectivity
Selective catalytic hydrogenation of g-amino a,b-unsaturated esters in the presence of hydrogenable protecting groups
No full text
Synthesis of (3R)- and (3S)-3,4-Diamino-Butyric Acid from L-Aspartic Acid
No full textA short and convenient synthesis for both enantiomers of GABOB amino-analogue is reported, starting from L-aspartic acid. The protected diester is the common intermediate for the synthetic pathway
Synthesis of (2R)- and (2S)-benzyl 2,3-epoxypropyl ether from a common precursor: O-benzyl-L-serine
No full textA stereoselective synthesis of both enantiomers of emeriamine from a single precursor: L-aspartic acid
No full text3-Aryl-2-oxazolidinones through the palladium-catalyzed N-arylation of 2-oxazolidinones
Full text link3-Aryl-2-oxazolidinones are obtained in good yields through the palladium-catalyzed N-arylation of 2-oxazolidinones with aryl bromides. The nature of aryl bromides, phosphine ligands, bases, and solvents strongly affects the reaction outcome
A synthesis of pyrrole derivatives from O-(2-hydroxyethyl) ketoximes
Full text linkAcetophenone, cyclohexanone, cycloheptanone, cyclo-octanone, and heptan-4-one were converted, via their
0-(2-hydroxyethyl)-oximes into the corresponding pyrrole derivatives, in satisfactory overall yields
- …
