102,333 research outputs found

    First-line steroid treatment for spontaneous intracranial hypotension

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    Background: Spontaneous intracranial hypotension (SIH) is a syndrome characterized by low cerebrospinal fluid (CSF) pressure and postural headaches, and affects 1 per 20,000 individuals every year. Case report: We report an otherwise healthy 38-year-old man admitted to the hospital with orthostatic headache that developed 48 h after a short-haul flight during which he sustained a neck injury due to turbulence. Neurological examination, blood analysis and computed tomography scan performed at the emergency service were normal. Brain and spine magnetic resonance imaging (MRI) showed diffuse pachymeningeal enhancement and contrast medium egress from the subarachnoid space into the epidural space at the level of C2. The patient was treated with bed rest, hydration and 1 mg/kg/day oral prednisone for 5 days, with a gradual withdrawal in the following 7 days. Complete symptomatic relief was observed after 16 days, with resolution of the pathological findings on brain and spinal MRI after 1 month, except for localized pachymeningeal enhancement. Clinical relief was maintained over time until last follow-up visit 9 months later. Conclusion: Successful conservative treatment barely exceeds one quarter of cases of SIH. The clinical benefits of steroids may result from several mechanisms of action, for example, improving brain oedema and inflammation, determining fluid retention, and facilitating reabsorption of the CSF from extradural space. Notwithstanding that epidural blood patch remains the most successful treatment for SIH, future studies should explore the effectiveness of steroids as first-line therapy in addition to the most commonly suggested measures of bed rest and hydration

    Complications of microwave ablation for liver tumors: Results of a multicenter study

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    Purpose New technologies for microwave ablation (MWA) have been conceived, designed to achieve larger areas of necrosis compared with radiofrequency ablation (RFA). The purpose of this study was to report complications by using this technique in patients with focal liver cancer. Methods Members of 14 Italian centers used a 2.45- GMHz generator delivering energy through a cooled miniature- choke MW antenna and a standardized protocol for follow-up. They completed a questionnaire regarding number and type of deaths, major and minor complications and side effects, and likelihood of their relationship to the procedure. Enrollment included 736 patients with 1.037 lesions: 522 had hepatocellular carcinoma with cirrhosis, 187 had metastases predominantly from colorectal cancer, and 27 had cholangiocellular carcinoma. Tumor size ranged from 0.5 to 10 cm. In 13 centers, the approach used was percutaneous, in 4 videolaparoscopic, and in 3 laparotomic. Results No deaths were reported. Major complications occurred in 22 cases (2.9%), and minor complications in 54 patients (7.3%). Complications of MWA do not differ from those RFA, both being based on the heat damage. Conclusion Results of this multicenter study confirmed those of single-center experiences, indicating that MWA is a safe procedure, with no mortality and a low rate of major complications. The low rate of complications was probably due to precautions adopted, knowing in advance possible risk conditions, on the basis of prior RFA experience. © Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011

    Impact of COVID-19 Outbreak on Healthcare Workers in Italy: Results from a National E-Survey

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    Italy has been the first-hit European country to face the outbreak of coronavirus disease 2019 (COVID-19). Aim of this survey was to assess in depth the impact of the outbreak on healthcare workers (HCW). A 40-item online survey was disseminated via social media inviting Italian HCW, with questions exploring demographics, health status and work environment of respondents. A total of 527 were invited to take part in March 2020, of whom 74% (n = 388) responded to the survey. Of these, 235 (61%) were women. HCW were mostly physicians (74%), from high-prevalence regions (52%). 25% experienced typical symptoms during the last 14 days prior to survey completion, with only 45% of them being tested for COVID-19. Among the tested population, 18 (18%) resulted positive for COVID-19, with 33% being asymptomatic. Only 22% of HCW considered personal protective equipment adequate for quality and quantity. Females and respondents working in high-risk sectors were more likely to rate psychological support as useful (OR, 1.78 [CI 95% 1.14–2.78] P = 0.012, and 2.02 [1.12–3.65] P = 0.020, respectively) and workload as increased (mean increase, 0.38 [0.06–0.69] P = 0.018; and 0.54 [0.16–0.92] P = 0.005, respectively). The insights from this survey may help authorities in countries where COVID-19 epidemic has not yet broken out. Management strategies should be promptly undertaken in order to enhance safety and optimise resource allocation

    Lo scavo del teatro romano di Aquileia: ricerche in corso

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    Dal 2015 il Dipartimento dei Beni Culturali dell’Università di Padova opera ad Aquileia nell’ampio terreno compreso tra le Grandi terme a sud e le mura bizantine a nord, con l’obiettivo primario di indagare i resti del teatro romano della città altoadriatica. Inizialmente una serie di prospezioni geofisiche e le prime verifiche archeologiche hanno permesso di accertare la presenza del teatro aquileiese nell’area dei fondi ex Comelli-Moro, come già ipotizzato da Luisa Bertacchi. Le successive indagini hanno consentito di precisare la collocazione topografica dell’edificio e di ricostruire l’articolazione planimetrica e l’ampiezza complessiva della cavea. Tra i molteplici obiettivi delle ricerche in corso rientrano lo studio planimetrico-strutturale del teatro e la ricostruzione della sua decorazione architettonica, per la quale si offrono in questa sede alcuni dati preliminari. Parallelamente, particolare attenzione è rivolta alle attività di rilievo e di restituzione grafica, sia di tipo tradizionale sia con metodologia 3D

    Efeito da virose do enrolamento da folha na composição química do vinho Cabernet Franc.

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    Foram comparados vinhos da cultivar Cabernet Franc (Vitis vinifera L.) provenientes de plantas sadias e atacadas pela virose do enrolamento da folha. O experimento foi realizado em Bento Gonçalves, RS, durante as safras de 1986, 1987, 1988, 1990 e 1991. O vinhedo foi instalado em 1982, sendo as videiras enxertadas sobre o porta-enxerto '101-14' e dispostas em 10 fileiras divididas por plantas sadias e plantas doentes. Os vinhos foram elaborados pelo processo de microvinificação a partir de 20kg de uva colhidos de maneira homogênea em toda a área. Os principais efeitos da virose na composição dos vinhos foram a diminuição do teor alcoólico, pH, cinzas, intensidade de cor e polifenóis totais. A virose também diminuiu o teor de acetato de etila e a soma de álcoois superiores. Quanto aos minerais, a virose determinou uma diminuição do K e Rb e um aumento nos teores de Ca e Mg
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