621 research outputs found

    Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations.

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    Background The revolution in coronary care in the mid-1980s to mid-1990s corresponded with monitoring of coronary heart disease (CHD) in 31 populations of the WHO MONICA Project. We studied the impact of this revolution on coronary endpoints. Methods Case fatality, coronary-event rates, and CHD mortality were monitored in men and women aged 35-64 years in two separate 3-4-year periods. In each period, we recorded percentage use of eight treatments: coronary-artery reperfusion before, thrombolytics during, and beta-blockers, antiplatelet drugs, and angiotensin-converting-enzyme (ACE) inhibitors before and during non-fatal myocardial infarction. Values were averaged to produce treatment scores. We correlated changes across populations, and regressed changes in coronary endpoints on changes in treatment scores. Findings Treatment changes correlated positively with each other but inversely with change in coronary endpoints. By regression, for the common average treatment change of 20, case fatality fell by 19% (95% CI 12-26) in men and 16% (5-27) in women; coronary-event rates fell by 25% (16-35) and 23% (7-39); and CHD mortality rates fell by 42% (31-53) and 34% (17-50). The regression model explained an estimated 61% and 41% of variance for men and women in trends for case fatality, 52% and 30% for coronary-event rates, and 72% and 56% for CHD mortality. Interpretation Changes in coronary care and secondary prevention were strongly linked with declining coronary endpoints. Scores and benefits followed a geographical east-to-west gradient. The apparent effects of the treatment might be exaggerated by other changes in economically successful populations, so their specificity needs further assessment

    Search for the ZγZ\gamma decay mode of new high-mass resonances in pppp collisions at s=13\sqrt{s}=13 TeV with the ATLAS detector

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    This letter presents a search for narrow, high-mass resonances in the ZγZ\gamma final state with the ZZ boson decaying into a pair of electrons or muons. The s=13\sqrt{s}=13 TeV pppp collision data were recorded by the ATLAS detector at the CERN Large Hadron Collider and have an integrated luminosity of 140 fb1^{-1}. The data are found to be in agreement with the Standard Model background expectation. Upper limits are set on the resonance production cross section times the decay branching ratio into ZγZ\gamma. For spin-0 resonances produced via gluon-gluon fusion, the observed limits at 95% confidence level vary between 65.5 fb and 0.6 fb, while for spin-2 resonances produced via gluon-gluon fusion (or quark-antiquark initial states) limits vary between 77.4 (76.1) fb and 0.6 (0.5) fb, for the mass range from 220 GeV to 3400 GeV.Comment: 35 pages in total, author list starting page 18, 5 figures, 3 tables, submitted to Phys. Lett. B. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2018-4

    Measurement of the cross-sections of the electroweak and total production of a ZγZ \gamma pair in association with two jets in pppp collisions at s\sqrt{s} = 13 TeV with the ATLAS detector

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    This Letter presents the measurement of the fiducial and differential cross-sections of the electroweak production of a ZγZ \gamma pair in association with two jets. The analysis uses 140 fb1^{-1} of LHC proton-proton collision data taken at s\sqrt{s}=13 TeV recorded by the ATLAS detector during the years 2015-2018. Events with a ZZ boson candidate decaying into either an e+ee^+e^- or μ+μ\mu^+ \mu^- pair, a photon and two jets are selected. The electroweak component is extracted by requiring a large dijet invariant mass and a large rapidity gap between the two jets and is measured with an observed and expected significance well above five standard deviations. The fiducial ppZγjjpp \rightarrow Z \gamma jj cross-section for the electroweak production is measured to be 3.6 ±\pm 0.5 fb. The total fiducial cross-section that also includes contributions where the jets arise from strong interactions is measured to be 16.81.8+2.016.8^{+2.0}_{-1.8} fb. The results are consistent with the Standard Model predictions. Differential cross-sections are also measured using the same events and are compared with parton-shower Monte Carlo simulations. Good agreement is observed between data and predictions.Comment: 44 pages in total, author list starting page 27, 6 figures, 3 tables, submitted to PLB. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2018-36

    Measurement of the tt¯ cross section and its ratio to the Z production cross section using pp collisions at s=13.6 TeV with the ATLAS detector

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    The inclusive top-quark-pair production cross section σtt¯ and its ratio to the Z-boson production cross section have been measured in proton–proton collisions at s=13.6 TeV, using 29 fb−1 of data collected in 2022 with the ATLAS experiment at the Large Hadron Collider. Using events with an opposite-charge electron-muon pair and b-tagged jets, and assuming Standard Model decays, the top-quark-pair production cross section is measured to be σtt¯=850±3(stat.)±18(syst.)±20(lumi.) pb. The ratio of the tt¯ and the Z-boson production cross sections is also measured, where the Z-boson contribution is determined for inclusive e+e− and μ+μ− events in a fiducial phase space. The relative uncertainty on the ratio is reduced compared to the tt¯ cross section, thanks to the cancellation of several systematic uncertainties. The result for the ratio, Rtt¯/Z=1.145±0.003(stat.)±0.021(syst.)±0.002(lumi.) is consistent with the Standard Model prediction using the PDF4LHC21 PDF set
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