6,682 research outputs found
sj-pdf-1-aja-10.1177_15333175221085066 – Supplemental Material for Regulation of the Late Onset alzheimer’s Disease Associated <i>HLA-DQA1/DRB1</i> Expression
No full textSupplemental Material, sj-pdf-1-aja-10.1177_15333175221085066 for Regulation of the Late Onset alzheimer’s Disease Associated HLA-DQA1/DRB1 Expression by Xiaoyu Zhang, Meijaun Zou, Yuwei Wu, Danli Jiang, Ting Wu, Yihan Zhao, Di Wu, Jing Cui and Gang Li in American Journal of Alzheimer's Disease & Other Dementias</p
An efficient approach to probe bioactive components of herbal patches by 2D-carbon microfiber fractionation and multi-chamber membrane separation electrophoresis: Spatholobus suberectus Dunn as a case
No full textHerbal patches are widely used in clinics for their good curative effects. However, due to the complexity of plant matrices and the extremely low content of transdermal components, the individuation of their effective bioactive compounds represents a challenge: there is then a great need for an efficient method to reveal the bioactive ingredients of herbal patches. In this work, a wide-screening approach is proposed to an individuation of transdermal bioactive components in herbal patches obtained by Spatholobus suberectus Dunn (S. suberectus). Using a two-dimensional microscale carbon fiber/active carbon fiber system combined with a quadrupole time-of-flight high-resolution mass spectrometry (2DμCFs-QTOF-HRMS), a rapid and comprehensive analysis, lasting only 5 min, allowed the identification of 45 distinct polar components within S. suberectus extracts. Among these, 30 components exhibited a transdermal penetration estimated at values higher than 10 %. The key target, predicted by bioinformatics, was prostaglandin-endoperoxide synthase 2 (PTGS2). From the transdermal components of S. suberectus, four potential inhibitors of PTGS2 (protocatechuic acid, isoliquiritigenin, medicarpin, and catechin) were screened by multi-chamber membrane separation electrophoresis (MCMSE). The presence of binding pockets and action sites for medicarpin, isoliquiritigenin, and catechin determines higher binding energy towards PTGS2, with lower IC50 values (12.27, 9.08, and 41.68 μM, respectively). The high-throughput and high-sensitivity analysis by 2DμCFs-QTOF-HRMS, combined with a high-accuracy screening of MCMSE, provides strong technical support for the discovery of trace transdermal bioactive components of herbal patches. The integration of the two technologies could accelerate the study of action mechanisms, quality control, and product improvement of herbal patches
Native p-type transparent conductive CuI via intrinsic defects
No full textThe ability of CuI to be doped p-type via the introduction of native defects has been investigated using first-principles pseudopotential calculations based on density functional theory. The Cu vacancy has a lower formation energy than any of the other native defects, which include I vacancy (V(I)), Cu interstitial (Cu(i)), I interstitial (I(i)), Cu antisite (Cu(I)), and I antisite (I(Cu)). Combined with its shallow acceptor level, it offers sufficient hole concentrations in CuI. The natural band alignments as compared to zinc-blende ZnS, ZnSe, and ZnTe have also been calculated in order to further identify the p-type dopability of CuI. It is found that CuI has a relatively high valence band maximum and conduction band minimum, which also makes it easy to dope CuI p-type in terms of the doping limit rule. In addition, the small effective mass of the light hole-about 0.303m(0)-can provide high mobility and p-type conductivity in CuI. All of these results make CuI an ideal candidate for native p-type materials (C) 2011 American Institute of Physics. [doi:10.1063/1.3633220
Micro-scale Fracture Toughness Testing and Finite Element Analysis of Transparent Ceramics
No full textRelative surface energies of low-index planes and the effect of Europium segregants on grain boundary structure and fracture strength of magnesium aluminate spinel (MgAl2O4) bicrystals were evaluated by micro scale fracture tests and high-resolution electron microscopy. Single crystal specimens with {111}, {110}, and {100} boundary planes were bonded together using hot pressing to make {111}/{100} and {100}/{110} interfaces. Certain of the resulting specimens were doped with Eu. Micro cantilever deflection tests were employed to measure fracture toughness within each single crystal and at both bicrystal boundaries. Correlating surface energy with fracture energy measurements, the surface energies of {111}, {110}, and {100} planes were found to have a decreasing trend. High-angle annular dark-field-scanning transmission electron microscopy (HAADF-STEM) was utilized to characterize grain boundary structure and chemistry. Differences in Eu segregation behavior on the two grain boundaries resulted in differences in grain boundary structure and differences in corresponding interfacial fracture strength. Eu segregated more uniformly to the {111}/{100} interface where it bonded strongly to the {111} plane but not to the {100} plane. The doped {100}/{110} boundary was characterized by a lack of uniform segregation. Corresponding fractography work and an in-situ foil fracture test was carried out in addition at the interface, aiding the structure and fracture behavior analysis. Here, we demonstrate how micro-cantilever fracture toughness measurements on single crystal and individual grain boundaries can indicate surface energy trends. And by combining micro fracture tests and HAADF-STEM analysis, a method to investigate the correlation between the grain boundary structure and fracture strength was established to interpret how rare earth segregation behavior affects intrinsic toughening mechanisms of magnesium aluminate spinel.In recognition of the shortcomings of the microcantilever bend fracture test, a new micro-scale fracture test that uses a bowtie-shaped micro-beam specimen with a chevron notch was designed and employed in transparent ceramic toughness testing. This clamped-clamped specimen can produce stable crack growth in brittle materials. Cyclic loading causes progressive crack extension, thereby producing multiple fracture toughness results in one experiment. The symmetric geometry eliminates the mixed mode fracture that exists in single-ended cantilevers. A 3D finite element analysis (FEA) model built in ANSYS Mechanical APDL and Altair Hypermesh was used to relate the crack length to the beam compliance. Full analysis of the bowtie chevron specimen geometry sensitivity has been carried out with FEA. A detailed crack stability analysis was conducted combining different nano-mechanical testing system, loading conditions, FEA analysis and TEM experimental methods. MATLAB programming was utilized to process large experimental data and to apply a polynomial fit in establishing a compliance and crack extension length relationship. The fracture energy could then be evaluated using an energy approach (‘Work of Fracture’) by combining FEA and experimental data. The results of tests using fused quartz and a glass-ceramic material match very well with published fracture toughness values. This validates the new micro scale testing method that possesses a combination of advantages not available in any other testing methods
Youthhood
No full textTESTING-GROUND issue 03, Youthhood, examines worlds through youthful eyes, makes evident young ambitions, and questions how we can better empower young people to design cities, landscapes, and a planet that works for them. The issue includes contributions from: Carmel Keren, Jude Daniel Smith, Claire Edwards, Kazeem Kuteyi, Emmanuel Adarkwah, Reza Nik, Dan Cui, Kristofer Cullum-Fernandez, Fida Sassi, Simeon Shtebunaev, Daze Aghaji, Averill Dimabuyu, Sarri Elfaitouri, Rebecca McDonald-Balfour, and Ed Wall.
Rebecca McDonald-Balfour (Author), Jude Daniel Smith (Author), Daze Aghaji (Author), Carmel Keran (Author), Alexis Liu (Author), Dan Cui (Author), Kristofer Cullum-Fernandez (Author), Fida Sassi (Author), Averill Dimabuyu (Author), Ed
Impact damage of composite laminates with high-speed waterjet
No full textRain erosion may cause substantial damage to aircrafts during supersonic flight. Such event is investigated here via high-speed waterjet impact on composite laminates. An experimental setup is developed to produce waterjets with the speed up to 700m/s and a finite element model of the waterjet-composite impact event is established. The consistency of experiment and simulation results validates the adopted numerical methods. The distribution of the water-hammer pressure is non-uniform and the maximum pressure occurs near the contact periphery when the water is about to eject laterally. After a high-speed (300∼560m/s) waterjet impacts a composite laminate, the impacted surface depression is observed, and the typical surface damage presents a central region with no visible surface damage surrounded by a faded “failure ring” with resin removal, matrix cracking and minor fiber fracture. Delamination occurs at the interfaces of adjacent layers with unequal dimensions and longitudinal matrix cracking appears on the back surface. Both the velocity and the diameter of waterjets are crucial factors on CFRP damage extents. Water-hammer pressure, the stagnation pressure and propagation of stress waves are failure mechanisms for most matrix damage in CFRP impacted by waterjets.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Structural Integrity & Composite
Sampling and Reconstruction of Signals on Product Graphs
No full textIn this paper, we consider the problem of subsampling and reconstruction of signals that reside on the vertices of a product graph, such as sensor network time series, genomic signals, or product ratings in a social network. Specifically, we leverage the product structure of the underlying domain and sample nodes from the graph factors. The proposed scheme is particularly useful for processing signals on large-scale product graphs. The sampling sets are designed using a low-complexity greedy algorithm and can be proven to be near-optimal. To illustrate the developed theory, numerical experiments based on real datasets are provided for sampling 3D dynamic point clouds and for active learning in recommender systems.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Signal Processing System
Ban dao ti yi zhi jie gou zai guang cui hua he guang dian cui hua zhong de yan jiu
No full textLi, Qian = 半導體异质结构在光催化和光電催化中的研究 / 李乾.Thesis Ph.D. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 145-162).Abstracts also in Chinese.Title from PDF title page (viewed on 30, December, 2016).Li, Qian = Ban dao ti yi zhi jie gou zai guang cui hua he guang dian cui hua zhong de yan jiu / Li Qian
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