123 research outputs found
PLoS One
No full textIn England, during pandemic 2009 H1N1, vaccine efficacy and immunogenicity population studies in priority groups were rolled out in parallel to evaluate the pandemic vaccination programme. This provided a unique opportunity to compare immunogenicity and clinical protection in the same population and thus provide insights into the correlates of protection for the pandemic H1N1 2009 vaccine in risk groups. While clinical protection from AS03-adjuvanted pandemic 2009 H1N1 vaccine was high in those aged <25 years and pregnant women, effectiveness in older adults with chronic conditions has been found to be surprisingly poor. Here we present results from the immunogenicity study derived from the same population. Individuals from priority groups eligible for pandemic vaccination attending participating general practices were recruited. Pre and post-vaccination blood samples were collected and HI antibody testing to assess immune response to vaccination performed. The final cohort consisted of 610 individuals: 60 healthy children aged <5 years; 32 healthy pregnant women; 518 individuals from risk groups. Seroconversion rate in healthy children aged <5 years (87%, 95% CI: 75% to 94%) was higher than that of risk groups combined (65%, 95% CI: 61% to 69%) (p<0.001). Multivariable analysis of risk groups showed that the size of response in those who did seroconvert was lower in those who received the 2009/10 seasonal TIV (Fold effect: 0.52, 0.35 to 0.78). Predicted immunological boosting from higher pre-vaccine titres after 2009 pandemic H1N1 vaccination only occurred in children (seroconversion rate = 92%) and not in individuals aged 10 to 39 from risk groups (seroconversion rate = 74%). The lack of clinical protection identified in the same population in older adults from risk groups could be attributed to these lower seroresponses. Current immunogenicity licensing criteria for pandemic influenza vaccine may not correlate with clinical protection in individuals with chronic disease or immunocompromised
The China which is here : translating classical Chinese poetry
No full textThe thesis proposes to address how the tradition of translating Chinese poetry
in the English speaking world developed in the early twentieth century and has
continued. Problems relating to this issue, such as the great change in poetics and
intellectual atmosphere since 1915 when Cathay appeared, its impact on the
translation of Chinese poetry, and the universe of discourse of the two cultures
involved, those of the Chinese and the English speaking world, as well as the
constraints of the target system on the translations, will also be discussed.
The introduction provides an overview of the poetics that valued traditional
metres at the turn of the century, and applies polysystem theory to explain the lack of
enthusiasm for translations of classical Chinese poetry before 1915. Chapter 2
discusses the constraints of language, the poetics and universe of discourse in the
target system, suggesting that these constraints handicapped the widespread transfer of
classical Chinese poetry before 1915.
Chapter 3 examines xing, the poetic device in Chinese poetry that emphasizes
the poet's spontaneous response to nature and the merging of scene and feeling. The
very nature of xing defies any attempt to make it explicit. The chapter is divided into
two parts, discussing xing in the encoding and decoding process respectively. Readerresponse
criticism and phenomenology are also incorporated in the discussions. The
chapter is followed by an analysis of various attempts to translate poems that are
presented with zing in Chapter 4, which shows that there is a tendency on the part of
some translators to add logical links between the scene and the feelings expressed.
Chapter 5 looks at the translation strategies of Arthur Waley, investigating
the traditions of translating classical Chinese poetry that he has helped to build up.
The kind of smooth grammatical lines he uses and the Chineseness he conveys have
had great influence on subsequent translators. Chapter 6 studies Ezra Pound, with
special focus on his innovative work Cathay, and his juxtaposition techniques.
Chapter 7 studies Kenneth Rexroth's translations of Du Fu, while Chapter 8
examines Gary Snyder's translations of Cold Mountain. The vehicle of translating
Chinese poetry in general-- language and poetics-- was close to that of modern
poetry in the target culture.
Chapter 9, the conclusion, asserts that various strategies are adopted for
various purposes. It tries to place the position of the translators discussed in a
polysystem context. In the target system, poems are appreciated more for their charm
than their being supposedly faithful to an original. The image of China created
through translators remains distant. To the reader in the West, China is always far out
"there," not here
Emerg Infect Dis
No full textWe analyzed data from hospital admissions and enhanced mumps surveillance to assess mumps complications during the largest mumps outbreak in England and Wales, 2004-2005, and their association with mumps vaccination. When compared with nonoutbreak periods, the outbreak was associated with a clear increase in hospitalized patients with orchitis, meningitis, and pancreatitis. Routine mumps surveillance and hospital data showed that 6.1% of estimated mumps patients were hospitalized, 4.4% had orchitis, 0.35% meningitis, and 0.33% pancreatitis. Enhanced surveillance data showed 2.9% of mumps patients were hospitalized, 6.1% had orchitis, 0.3% had meningitis, and 0.25% had pancreatitis. Risk was reduced for hospitalization (odds ratio [OR] 0.54, 95% confidence interval [CI] 0.43-0.68), mumps orchitis (OR 0.72, 95% CI 0.56-0.93) and mumps meningitis (OR 0.28, 95% CI 0.14-0.56) when patient had received 1 dose of measles, mumps, and rubella vaccine. The protective effect of vaccination on disease severity is critical in assessing the total effects of current and future mumps control strategies
Timeliness of childhood vaccination coverage: the Growing Up in Singapore Towards Healthy Outcomes Study
No full textStudies investigating timeliness for childhood vaccination are limited especially in Asia. We examined the timeliness of vaccine administration and associated factors among infant and young children in Singapore. A total of 782 children born between November 2009 and July 2011 from a prospective cohort in Singapore were studied. Vaccination records from birth to 24 months of age were obtained from the National Immunization Registry of Singapore. Multivariable logistic regression models were performed. By 2 years of age, 92.8% of children in our cohort experienced a delay in receiving 1 or more vaccine doses according to the recommended national immunization schedule. When vaccinations were reviewed by series for each vaccine, 15.6% received all vaccine series outside the recommended age ranges. Factors associated with receiving vaccination series outside the recommended ages included maternal aged ≤ 35 years (OR 2.00; 95% CI 1.09, 3.66), Malay (1.71; 1.01, 2.89) or Indian ethnicity (2.06; 1.19, 3.59), low monthly household income (1.91; 1.14, 3.18), having at least four children (3.46; 1.62, 7.38) and private (3.42; 1.80, 6.48) and multiple vaccination providers (3.91; 1.23, 12.48). These findings show an unacceptably high proportion of children experienced a delay in the receipt of their vaccinations. The identification of several demographic, socioeconomic, health-seeking behavioural and vaccine provider factors provides opportunities for targeted interventions to enhance the timeliness of childhood vaccination in Singapore.</p
Guillain-Barré Syndrome and Zika Virus: Estimating Attributable Risk to Inform Intensive Care Capacity Preparedness: Table 1.
No full textPrice Discovery in Real Estate Auctions: The Story of Unsuccessful Attempts
No full textLittle is known of the effects of the auction mechanism in relation to post-auction market sales. This empirical study of unsuccessful auctions shows that approximately half of these properties were eventually sold via private negotiations, at higher prices relative to last bids. The probability of a subsequent post-auction transaction is significantly higher for apartments and terrace houses and when auction turnout is high; and lower in the absence of any bid and in some years. In addition, downward revisions to the opening bid improve the probability of subsequent sale. Prices of subsequent re-auctioned and privately negotiated sales decline with time to sale, consistent with the search process explanation.
Power-control design of resonant converters
No full textNovel design techniques are presented for load-resonant and quasi-resonant converters for
use in, for example, arc-welding and fan-load power supplies. Both converters are capable of
very high switching frequency over a wide range of output power, with high efficiency and the
presentation of near-unity power factor to the primary power supply.
Previous work, by the author and his colleagues, has produced. a frequency-domain approach
to produce circuit-designs for use in load-resonant converter applications. This design technique,
although simple and straight-forward to understand, suffers by requiring some rather tedious
trial-and-error algebraic and arithmetic manipulations albeit computer assisted. In this thesis, a
systematic way of designing such circuits, based on Gr6bner Basis ideas, is explained, developed
and compared with the previous best-practice design method. By employing the Gr6bner Basis
techniques to synthesize electrical circuits, an entirely novel approach to the design of series-parallel
load-resonant converter circuits is presented. This has led to the formulation of a new
output-power control methodology in the design of the converters. These techniques produce
output-power-control designs that have superior properties, compared with other established
methods, in the sense of their simplicity, robustness and flexibility.
It is found that the methodology can be further extended to alter any resonant circuits and,
hence enables multilevel-output power to be controlled without involving complex control and
advanced mathematical theories, while still preserving the desirable characteristics of resonant
switching. The technique is, in fact, far more generally useful in the circuit-design/synthesis
arena than the specific load-resonant-converter application for which it was developed.
The novel technique used to vary the speed of an induction motor is found to be promising.
Various test results are presented based on an experimental system
Acceptance and uptake of influenza vaccines in Asia: A systematic review
No full textIn Asia, the public health burden of influenza is significant despite the existence of efficacious influenza vaccines. Annual seasonal influenza vaccination can reduce the incidence of influenza significantly, yet influenza vaccination coverage remains low in this part of the world. As a densely populated region with varying climatic zones and a larger proportion of developing countries compared to the West, Asia is at increased risk of influenza. To provide a more comprehensive and nuanced understanding of the Asian region, the key objective of this systematic review is to examine the determinants of vaccination uptake in Asia, beyond that of existing studies that have largely been western-centric.
We carried out a systematic review of peer-reviewed scientific research, examining the key determinants, acceptance and uptake of influenza vaccinations across Asia. A comprehensive search strategy was defined to capture studies that met the inclusion criteria of articles published in English, from 2008 to 2018, focusing on adult populations within Asia. A total of 83 relevant studies were appraised in this review. Analyses of the extant data confirmed that vaccination rates within Asia are low, and that most countries lack scientific research on vaccination behaviours. Studies were categorised into four different population groups: healthcare workers, high risk groups, general population and uniform groups. The motivators and deterrents for vaccine uptake varied according to population groups and characteristics. Both general populations and healthcare workers were concerned with vaccine safety and efficacy, and recommendations from health authorities were influential in vaccine uptake within the other populations.
The findings suggest that further research is needed within a broader range of Asian countries to garner greater in-depth knowledge of vaccination behaviours in the region. In particular, influenza vaccination programs within Asia should focus on improving engagement more effectively, through greater relatability and transparency of data when educating the public.Ministry of Health (MOH)This research is supported by the Singapore Ministry of Health's Communicable Diseases Public Health Research Grant MOH/CDPHRG/0017/2015
Emerg Infect Dis
No full textRespiratory syncytial virus (RSV) is the most common cause of pediatric acute lower respiratory tract infection worldwide. Detailed data on the health and economic burden of RSV disease are lacking from tropical settings with year-round RSV transmission. We developed a statistical and economic model to estimate the annual incidence and healthcare cost of medically attended RSV disease among young children in Singapore, using Monte Carlo simulation to account for uncertainty in model parameters. RSV accounted for 708 hospitalizations in children <6 months of age (33.5/1,000 child-years) and 1,096 in children 6-29 months of age (13.2/1,000 child-years). The cost of hospitalization was SGD 5.7 million (US $4.3 million) at 2014 prices; patients bore 60% of the cost. RSV-associated disease burden in tropical settings in Asia is high and comparable to other settings. Further work incorporating efficacy data from ongoing vaccine trials will help to determine the potential cost-effectiveness of different vaccination strategies
Interconnection networks for parallel and distributed computing
No full textParallel computers are generally either shared-memory machines or distributed- memory machines. There are currently technological limitations on shared-memory architectures and so parallel computers utilizing a large number of processors tend tube distributed-memory machines. We are concerned solely with distributed-memory multiprocessors. In such machines, the dominant factor inhibiting faster global computations is inter-processor communication. Communication is dependent upon the topology of the interconnection network, the routing mechanism, the flow control policy, and the method of switching. We are concerned with issues relating to the topology of the interconnection network. The choice of how we connect processors in a distributed-memory multiprocessor is a fundamental design decision. There are numerous, often conflicting, considerations to bear in mind. However, there does not exist an interconnection network that is optimal on all counts and trade-offs have to be made. A multitude of interconnection networks have been proposed with each of these networks having some good (topological) properties and some not so good. Existing noteworthy networks include trees, fat-trees, meshes, cube-connected cycles, butterflies, Möbius cubes, hypercubes, augmented cubes, k-ary n-cubes, twisted cubes, n-star graphs, (n, k)-star graphs, alternating group graphs, de Bruijn networks, and bubble-sort graphs, to name but a few. We will mainly focus on k-ary n-cubes and (n, k)-star graphs in this thesis. Meanwhile, we propose a new interconnection network called augmented k-ary n- cubes. The following results are given in the thesis.1. Let k ≥ 4 be even and let n ≥ 2. Consider a faulty k-ary n-cube Q(^k_n) in which the number of node faults f(_n) and the number of link faults f(_e) are such that f(_n) + f(_e) ≤ 2n - 2. We prove that given any two healthy nodes s and e of Q(^k_n), there is a path from s to e of length at least k(^n) - 2f(_n) - 1 (resp. k(^n) - 2f(_n) - 2) if the nodes s and e have different (resp. the same) parities (the parity of a node Q(^k_n) in is the sum modulo 2 of the elements in the n-tuple over 0, 1, ∙∙∙ , k - 1 representing the node). Our result is optimal in the sense that there are pairs of nodes and fault configurations for which these bounds cannot be improved, and it answers questions recently posed by Yang, Tan and Hsu, and by Fu. Furthermore, we extend known results, obtained by Kim and Park, for the case when n = 2.2. We give precise solutions to problems posed by Wang, An, Pan, Wang and Qu and by Hsieh, Lin and Huang. In particular, we show that Q(^k_n) is bi-panconnected and edge-bipancyclic, when k ≥ 3 and n ≥ 2, and we also show that when k is odd, Q(^k_n) is m-panconnected, for m = (^n(k - 1) + 2k - 6’ / ‘_2), and (k -1) pancyclic (these bounds are optimal). We introduce a path-shortening technique, called progressive shortening, and strengthen existing results, showing that when paths are formed using progressive shortening then these paths can be efficiently constructed and used to solve a problem relating to the distributed simulation of linear arrays and cycles in a parallel machine whose interconnection network is Q(^k_n) even in the presence of a faulty processor.3. We define an interconnection network AQ(^k_n) which we call the augmented k-ary n-cube by extending a k-ary n-cube in a manner analogous to the existing extension of an n-dimensional hypercube to an n-dimensional augmented cube. We prove that the augmented k-ary n-cube Q(^k_n) has a number of attractive properties (in the context of parallel computing). For example, we show that the augmented k-ary n-cube Q(^k_n) - is a Cayley graph (and so is vertex-symmetric); has connectivity 4n - 2, and is such that we can build a set of 4n - 2 mutually disjoint paths joining any two distinct vertices so that the path of maximal length has length at most max{{n- l)k- (n-2), k + 7}; has diameter [(^k) / (_3)] + [(^k - 1) /( _3)], when n = 2; and has diameter at most (^k) / (_4) (n+ 1), for n ≥ 3 and k even, and at most [(^k)/ (_4) (n + 1) + (^n) / (_4), for n ^, for n ≥ 3 and k odd.4. We present an algorithm which given a source node and a set of n - 1 target nodes in the (n, k)-star graph S(_n,k) where all nodes are distinct, builds a collection of n - 1 node-disjoint paths, one from each target node to the source. The collection of paths output from the algorithm is such that each path has length at most 6k - 7, and the algorithm has time complexity O(k(^3)n(^4))
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