818 research outputs found
Correction: Corrigendum: The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells
No full textScientific Reports 7: Article number: 42845; published online: 20 February 2017; updated: 22 December 2017. The original version of this Article contained an error in the spelling of the author Yuuki Imai, which was incorrectly given as Yu-ki Imai. This error has now been corrected in the PDF and HTML versions of the Article, and in the accompanying Supplementary Information.</jats:p
Angiotensin-Converting-Enzyme 2 (rhACE2) Potently Attenuates the Negative Hemodynamic Effects of Angiotensin II (ATII) and Improves Post-Myocardial Infarction (MI) Remodeling
No full textAngiotensin-Converting-Enzyme 2 (rhACE2) Potently Attenuates the Negative Hemodynamic Effects of Angiotensin II (ATII) and Improves Post-Myocardial Infarction (MI) Remodeling
No full textMinedition
No full textThis is a lovely book I happened to find when I was trying to spend down the little money left on my Eurocheck debit card in the late days of my stay in Mannheim. The book is unusual in opening not from right to left but from down to up; that is, one needs to hold it sideways and lift the cover. The cover picture shows the half-painted jackdaw as he returns after opening his craw and being recognized by the doves whose food he was eating. Why does his fellow jackdaw have various colored feathers protruding from his black body and even one such feather in his beak? The pearl that the rooster finds in CJ is part of a ring. The little goat dancing for the wolf uses a hula-hoop! The expanding frog in OF is about to reach the ceiling of a modernistic garden-house! He is elevated off the floor like a helium-filled balloon. The one illustration for FS includes both the plate for the stork and the vase for the fox. In fact, the wall behind the stork features several plates and the floor behind the fox shows three large vases with steam bubbles emerging from them. The resting hare in TH has a hammock slung across the trail. The dropped meat bubbles through the text, dividing its lines in DS. The grapes break down through the ceiling of the fox's room in FG as clouds blow through the windows. The city mouse is fishing in the soup at the city meal in TMCM! A highway--or a racetrack?--winds among cheese wedges and salt and pepper shakers in this fable's tailpiece. The rack of the stag in the pool reaches out like a tree and even includes a birdhouse! What lovely imaginative work! The book is, as regularly with Neugebauer, beautifully produced.This is a hardbound book (hard cover)Language note: GermanNacherzählt von Renate Raeck
伝統的建造物群保存地区におけるイベント型観光の可能性 －橿原市今井町の事例－
No full textMany important preservation districts of groups of historic buildings have developed as tourist destinations in Japan. But Imai-cho in the City of Kashihara - one of the most famous historical districts in Japan - is situated as residential zone in Kasihara city planning and previous studies said that residents in Imai-cho did not want to develop their district as a normal tourist destination. Therefore, this article aims to examine the possibility of developing an event tourism in the Imai-cho. Events opened on each Saturday and Sunday in November in 2009. Many events, such as concerts, lectures, bar and so forth opened from Saturday afternoon to Sunday afternoon. In these events, some tourists stayed at historical buildings. The author examines the assessments of these events by the questionnaire to tourists and residents in the Imai-cho. There are many tourist attractions such as public open spaces, museums and important cultural properties in the Imai-cho. But souvenir shops and eating and drinking places are not plenty for tourists and there is no main shopping street in the Imai-cho. Most of tourists lived within Kinki region. They usually went to other destinations after they stayed in the Imai-cho during only few hours. They hoped the Imai-cho will develop as historical tourist destination. But some tourists and residents hoped the Imai-cho not to develop as a normal tourist destination. They hoped to develop the event tourism in the Imai-cho in order to preserve life of residents.departmental bulletin pape
Pathogenesis and therapeutic targets for severe respiratory failure mediated by emerging respiratory virus infection
No full textN-Methyl-D-aspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection
No full textKo Tsutsui,1 Takashi Kanbayashi,1,2 Manabu Takaki,3 Yuki Omori,1 Yumiko Imai,4 Seiji Nishino,5 Keiko Tanaka,6 Tetsuo Shimizu1,2 1Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, 2International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, 3Department of Neuropsychiatry, Okayama University, Okayama, 4Biological Informatics and Experimental Therapeutics, Akita University Graduate School of Medicine, Akita, Japan; 5Sleep and Circadian Neurobiology Laboratory, Stanford University School of Medicine, Palo Alto, California, USA; 6Brain Research Institute, Niigata University, Niigata, Japan Abstract: The symptoms of catatonia have been reported to be similar to the initial symptoms of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Subsequently, this autoimmune limbic encephalitis has been noticed by many psychiatrists. For a differential diagnosis of catatonic state, it is important to detect anti-NMDAR encephalitis. This encephalitis is expected to be in remission by early detection and treatment. We should be more cautious about catatonic symptoms of schizophrenia. When a patient is being doubted with encephalitis, we should screen for anti-NMDAR antibodies in cerebrospinal fluid samples using a cell-based assay. We describe the methods of NMDAR antibody detection and the etiology of this encephalitis with case reports. Two representative cases with catatonia and non-catatonia (brief psychotic disorder) were reported. Schizophrenia is a general, heterogeneous, and complicated disorder, and its pathophysiology is unknown. There is an established evidence of NMDAR hypofunction, which is the functional disconnection of the central component; this is one of the most recognized models for schizophrenia. Furthermore, it is said that autoimmune mechanisms have been involved, at least in subgroups of schizophrenia patients. Further study of anti-NMDAR antibody and its related encephalitis would give essential clues for the research of schizophrenia, catatonia, and atypical psychosis. Keywords: NMDA receptor, encephalitis, antibody, psychosis, catatoni
Voucher privatization with investment funds : an institutional analysis
No full textCommon wisdom among post-socialist reformers has beento use voucher investment funds to provide the corporate governance needed to restructure newly privatized enterprises after mass privatization efforts. The idea has been that mass privatization would spread the ownership too wide and make corporate governance difficult. The author examines the likely institutional behavior of voucher funds and the possible effects of their development on a transition economy. Since most policy advice has been in favor of voucher privatization with investment funds, the author can be seen as playing the devil's advocate, but his argument is institutional, not statistical. Policymaking requires insight and foresight into how institutions will tend to function. He concludes that voucher funds will introduce a bias in the economy away from the real industrial sector toward an ersatz"financial sector"that will have little if any positive financial role but will be well-protected by friendly regulators. One long-term consequence of voucher privatization with investment funds, according to this view, is a de facto"industrial policy"of real sector decapitalization in favor of short-term rent-seeking by fund managers through board sinecures and lucrative side deals with portfolio companies and through financial market manipulation and paper entrepreneurship in the"financial sector."Without strong corporate governance from the funds and without stable ownership of their own, many enterprise managers will exploit the post-socialist version of the"separation of ownership and control"to grab what they can in the form of salaries, bonuses, perquisites, and side deals. The most likely results of the strategy of voucher privatization with investment funds may be a two-sided grab fest by fund managers and enterprise managers -- together with the accompanying drift, stagnation, and decapitalization of the privatized industrial sector.Economic Adjustment and Lending,Payment Systems&Infrastructure,International Terrorism&Counterterrorism,Economic Theory&Research,Banks&Banking Reform,International Terrorism&Counterterrorism,Banks&Banking Reform,Economic Adjustment and Lending,Environmental Economics&Policies,Economic Theory&Research
Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies
No full textThe current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal µPIV/PTV. By using a confocal µPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 µm circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit
Ventilator-induced lung injury, cytokines, PEEP, and mortality: implications for practice and for clinical trials
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