2,498 research outputs found
Restless legs syndrome—current therapies and management of augmentation
No full textIdiopathic restless legs syndrome (RLS) can severely affect quality of life and disturb sleep, so that pharmacological treatment is necessary, especially for elderly patients. Treatment guidelines recommend initiation of therapy with dopamine agonists (pramipexole, ropinirole or the rotigotine transdermal patch, all approved in most countries) or alpha-2-delta ligands (gabapentin enacarbil, approved in the USA and Japan), depending on the country and availability. Where approved, opioids (prolonged release oxycodone-naloxone, approved in Europe) are also recommended as a second-line therapy for severe RLS. Several iron formulations can be effective but are not yet approved for RLS therapy, whereas benzodiazepines and other anticonvulsants are not recommended or approved. Less is known about effective management of RLS that is associated with other conditions, such as uraemia or pregnancy. Furthermore, very little data are available on the management of RLS when first-line treatment fails or patients experience augmentation. In this Review, we summarize state-of-the-art therapies for RLS in the context of the diagnostic criteria and available guidelines, based on knowledge ranging from Class I evidence for the treatment of idiopathic RLS to Class IV evidence for the treatment of complications such as augmentation. We consider therapies, including combination therapies, that are used in clinical practice for long-term management of RLS, despite a lack of trials and approval, and highlight the need for practical long-term evaluation of current trials
Systematic-error-free wavefront measurement using an X-ray single-grating interferometer
No full textTakato Inoue, Satoshi Matsuyama, Shogo Kawai, Hirokatsu Yumoto, Yuichi Inubushi, Taito Osaka, Ichiro Inoue, Takahisa Koyama, Kensuke Tono, Haruhiko Ohashi, Makina Yabashi, Tetsuya Ishikawa, and Kazuto Yamauchi, "Systematic-error-free wavefront measurement using an X-ray single-grating interferometer", Review of Scientific Instruments 89, 043106 (2018), https://doi.org/10.1063/1.5026440.In this study, the systematic errors of an X-ray single-grating interferometer based on the Talbot effect were investigated in detail. Non-negligible systematic errors induced by an X-ray camera were identified and a method to eliminate the systematic error was proposed. Systematic-error-free measurements of the wavefront error produced by multilayer focusing mirrors with large numerical apertures were demonstrated at the SPring-8 Angstrom Compact free electron LAser. Consequently, wavefront aberration obtained with two different cameras was found to be consistent with an accuracy better than λ/12
Paleo-tsunami history along the northern Japan Trench: evidence from Noda Village, northern Sanriku coast, Japan
No full textAbstract Throughout history, large tsunamis have frequently affected the Sanriku area of the Pacific coast of the Tohoku region, Japan, which faces the Japan Trench. Although a few studies have examined paleo-tsunami deposits along the Sanriku coast, additional studies of paleo-earthquakes and tsunamis are needed to improve our knowledge of the timing, recurrence interval, and size of historical and pre-historic tsunamis. At Noda Village, in Iwate Prefecture on the northern Sanriku coast, we found at least four distinct gravelly sand layers based on correlation and chronological data. Sedimentary features such as grain size and thickness suggest that extreme waves from the sea formed these layers. Numerical modeling of storm waves further confirmed that even extremely large storm waves cannot account for the distribution of the gravelly sand layers, suggesting that these deposits are highly likely to have formed by tsunami waves. The numerical method of storm waves can be useful to identify sand layers as tsunami deposits if the deposits are observed far inland or at high elevations. The depositional age of the youngest tsunami deposit is consistent with the AD 869 Jogan earthquake tsunami, a possible predecessor of the AD 2011 Tohoku-oki tsunami. If this is the case, then the study site currently defines the possible northern extent of the AD 869 Jogan tsunami deposit, which is an important step in improving the tsunami source model of the AD 869 Jogan tsunami. Our results suggest that four large tsunamis struck the Noda site between 1100 and 2700 cal BP. The local tsunami sizes are comparable to the AD 2011 and AD 1896 Meiji Sanriku tsunamis, considering the landward extent of each tsunami deposit
Shortcomings of a parametric VaR approach and nonparametric improvements based on a non-stationary return series model
No full textA non-stationary regression model for financial returns is examined theoretically in this paper. Volatility dynamics are modelled both exogenously and deterministic, captured by a nonparametric curve estimation on equidistant centered returns. We prove consistency and asymptotic normality of a symmetric variance estimator and of a one-sided variance estimator analytically, and derive remarks on the bandwidth decision. Further attention is paid to asymmetry and heavy tails of the return distribution, implemented by an asymmetric version of the Pearson type VII distribution for random innovations. By providing a method of moments for its parameter estimation and a connection to the Student-t distribution we offer the framework for a factor-based VaR approach. The approximation quality of the non-stationary model is supported by simulation studies. --heteroscedastic asset returns,non-stationarity,nonparametric regression,volatility,innovation modelling,asymmetric heavy-tails,distributional forecast,Value at Risk (VaR)
Capacitors
No full textThis webpage is part of a larger site by the author about electronic circuit engineering. This page introduces the reader to capacitors, including the principles behind how they work. Explanations of several different types of capacitors (including Electrolytic, Tantalum, and Mica) are accompanied by detailed color illustrations of the concepts
Partial endorsement of “Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline” by the World Sleep Society
No full textLecideoid lichens of Prince Olav Coast and Soya Coast, Enderby Land, East Antarctica
No full textFive species of lecideoid lichens belonging to three genera are reported as new to the flora of the Prince Olav Coast and the Soya Coast, Enderby Land, East Antarctica; they are Carbonea capsulata (DODGE & BAKER) HALE, Lecidea andersonii R. FILSON, Lecidea cancriformis DODGE & BAKER, Lecidea soyaensis M. INOUE and Lecidella siplei (DODGE & BAKER) M. INOUE. All are endemic to Antarctica. An examination was made of the collections from the region, which were collected mainly by the author under the project of the 27th Japanese Antarctic Research Expedition (JARE-27,during January 1986 and February 1987). The type and authentic specimens of possibly related species have been restudied. Lecidea soyaensis M. INOUE is new to science and Lecidella siplei (DODGE & BAKER) M. INOUE is proposed as a new combination. Taxonomic and chemical data as well as a key to the known taxa are provided
The Hobby of Electronic Circuit Engineering
No full textThis website (originally created in Japanese and translated into English using translation software) by a Japanese systems engineer, Seiichi Inoue, provides an extensive overview of electronic circuit engineering. Topics covered include: Basic knowledge of Electronic parts, Basic knowledge of Engineering Instruments, an Introduction of Engineering Method, and the Assembly Process. A variety of electronic circuits and their uses are provided, as well as a separate section on PIC electronic circuits. The language may be difficult to follow at times given the translation, but still a gem of a site for anyone wanting to build some circuits! Keep in mind that in some sections, the author notes that he is "describing while studying, there seems to be mistakes in the contents. Do at your own risk." For some further browsing, he includes sections on his other interests, such as 3D photography, java programming, CAD, Japanese customs and the Japanese language
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