65 research outputs found
Imunidade inata, patogênese e diagnóstico de salmonelose, brucelose e leishmaniose
No full textThis work provides a systematic and critical review of part of the scientific production of its author. It includes three research topics, namely salmonellosis, brucellosis, and leishmaniasis. Each one of these topics is discussed in individual chapters. Most of the data discussed here refers to pathology, pathogenesis, hostpathogen interactions, innate immunity, and diagnosis of these diseases. Instead of being organized as a traditional literature reviews, the chapters actually emphasize the scientific contribution of the author’s publications in each of these fields.Este trabalho traz uma revisão sistemática e crítica de parte da produção científica de seu autor. O trabalho incluiu três linhas de pesquisa, incluindo a salmonelose, brucelose e leishmaniose. Cada uma destas linhas é discutida em um capítulo individual. A maior parte dos dados discutidos neste trabalho se referem a patologia, patogênese, interação patógeno-hospedeiro, imunidade inata e diagnóstico destas doenças. Ao invés de serem organizados como revisão de literatura tradicional, os capítulos enfatizam a contribuição científica das publicações do autor nestas áreas do conhecimento
Imunidade inata, patogênese e diagnóstico de salmonelose, brucelose e leishmaniose
No full textThis work provides a systematic and critical review of part of the scientific production of its author. It includes three research topics, namely salmonellosis, brucellosis, and leishmaniasis. Each one of these topics is discussed in individual chapters. Most of the data discussed here refers to pathology, pathogenesis, hostpathogen interactions, innate immunity, and diagnosis of these diseases. Instead of being organized as a traditional literature reviews, the chapters actually emphasize the scientific contribution of the author’s publications in each of these fields.Este trabalho traz uma revisão sistemática e crítica de parte da produção científica de seu autor. O trabalho incluiu três linhas de pesquisa, incluindo a salmonelose, brucelose e leishmaniose. Cada uma destas linhas é discutida em um capítulo individual. A maior parte dos dados discutidos neste trabalho se referem a patologia, patogênese, interação patógeno-hospedeiro, imunidade inata e diagnóstico destas doenças. Ao invés de serem organizados como revisão de literatura tradicional, os capítulos enfatizam a contribuição científica das publicações do autor nestas áreas do conhecimento
Imunidade inata, patogênese e diagnóstico de salmonelose, brucelose e leishmaniose
No full textThis work provides a systematic and critical review of part of the scientific production of its author. It includes three research topics, namely salmonellosis, brucellosis, and leishmaniasis. Each one of these topics is discussed in individual chapters. Most of the data discussed here refers to pathology, pathogenesis, hostpathogen interactions, innate immunity, and diagnosis of these diseases. Instead of being organized as a traditional literature reviews, the chapters actually emphasize the scientific contribution of the author’s publications in each of these fields.Este trabalho traz uma revisão sistemática e crítica de parte da produção científica de seu autor. O trabalho incluiu três linhas de pesquisa, incluindo a salmonelose, brucelose e leishmaniose. Cada uma destas linhas é discutida em um capítulo individual. A maior parte dos dados discutidos neste trabalho se referem a patologia, patogênese, interação patógeno-hospedeiro, imunidade inata e diagnóstico destas doenças. Ao invés de serem organizados como revisão de literatura tradicional, os capítulos enfatizam a contribuição científica das publicações do autor nestas áreas do conhecimento
Complex effects of high-flow nasal cannula therapy on hemodynamics in the pediatric patient after cardiac surgery
No full textAbstract Background The high-flow nasal cannula (HFNC) system has been widely used for children in various clinical settings. However, the physiological and clinical impact of HFNC therapy on the pediatric patient with respiratory distress after cardiac surgery has not been thoroughly investigated. Main body of the abstract It seems logical to use HFNC as a primary therapy for post-extubation respiratory failure after congenital heart surgery, in which low cardiac output syndrome and upper airway obstruction are commonly encountered; the HFNC therapy alleviates the work of breathing and large negative swings of intrathoracic pressure, which in turn helps to decrease the systemic ventricular afterload. When applying HFNC to patients after congenital heart surgery, however, consideration must be given to its diverse effects on hemodynamics because of the complex respiratory and cardiac pathophysiology in these patients. The positive pressure generated by HFNC can exert different effects on pulmonary vascular resistance depending on the lung condition, while its impact on cardiac output may also differ depending on the cardiac physiology. The hemodynamic effects of HFNC may become even more complex in a patient with a single ventricle. To better assess its physiologic effects in patients after cardiac surgery, future studies could utilize various modalities including esophageal balloon catheters, electrical impedance tomography, and near-infrared spectroscopy. At the same time, studies should focus on specific types of cardiac pathophysiology or surgery when evaluating the effects of HFNC, since it may exert various effects, depending on the cardiac physiology or preoperative pulmonary hemodynamics. Lastly, the optimal flow rate at which the benefit of HFNC is maximized through favorable cardiopulmonary interactions should be determined in future studies. Short conclusion Further studies are needed to better understand the effect of HFNC in different cardiac and respiratory physiologies, given their complexity in pediatric patients after cardiac surgery
Ventilator auto-triggering by cardiac electrical activity during noninvasive ventilation with neurally adjusted ventilatory assist
No full textDoes Driving Pressure Matter in Pediatric Acute Respiratory Distress Syndrome? Strain to Find the Answer
No full textComplex effects of high-flow nasal cannula therapy on hemodynamics in the pediatric patient after cardiac surgery
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