2,763 research outputs found
Importance Sampling for Thermally Induced Switching and Non-Switching Probabilities in Spin-Torque Magnetic Nanodevices
No full textSpin-transfer torque magnetoresistive random access memory is a potentially transformative technology in the non-volatile memory market. Its viability depends, in part, on one's ability to predictably induce or prevent switching; however, thermal fluctuations cause small but important errors in both the writing and reading processes. Computing these very small probabilities for magnetic nanodevices using naive MC simulations is essentially impossible due to their slow statistical convergence, but variance reduction techniques can offer an effective way to improve their efficiency. Here, we provide an illustration of how importance sampling can be efficiently used to estimate low read and write soft error rates of macrospin and coupled-spin systems
sj-docx-2-jet-10.1177_15266028211032956 – Supplemental material for Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching
No full textSupplemental material, sj-docx-2-jet-10.1177_15266028211032956 for Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching by Huan Xu, Ziqiang Wu, Zhong Jin, Xiao Wu, Wangming Hu, Bing Liang, Guanhua Lou, Zixian Chen, Huan Yao, Xiongbing Chen, Xin Zhou, Han Xiao, Cenghao Yu, Delai Zhang, Daoying Gong, Lan Yang, Yaping Shi, Yiming Xu and Yong Wang in Journal of Endovascular Therapy</p
sj-pdf-3-jet-10.1177_15266028211032956 – Supplemental material for Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching
No full textSupplemental material, sj-pdf-3-jet-10.1177_15266028211032956 for Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching by Huan Xu, Ziqiang Wu, Zhong Jin, Xiao Wu, Wangming Hu, Bing Liang, Guanhua Lou, Zixian Chen, Huan Yao, Xiongbing Chen, Xin Zhou, Han Xiao, Cenghao Yu, Delai Zhang, Daoying Gong, Lan Yang, Yaping Shi, Yiming Xu and Yong Wang in Journal of Endovascular Therapy</p
sj-docx-1-jet-10.1177_15266028211032956 – Supplemental material for Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching
No full textSupplemental material, sj-docx-1-jet-10.1177_15266028211032956 for Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching by Huan Xu, Ziqiang Wu, Zhong Jin, Xiao Wu, Wangming Hu, Bing Liang, Guanhua Lou, Zixian Chen, Huan Yao, Xiongbing Chen, Xin Zhou, Han Xiao, Cenghao Yu, Delai Zhang, Daoying Gong, Lan Yang, Yaping Shi, Yiming Xu and Yong Wang in Journal of Endovascular Therapy</p
Supplemental Material, SI_figures - Comparison of Low-Molecular-Weight Heparins Prepared From Ovine Heparins With Enoxaparin
No full textSupplemental Material, SI_figures for Comparison of Low-Molecular-Weight Heparins Prepared From Ovine Heparins With Enoxaparin by Jianle Chen, Yanlei Yu, Jawed Fareed, Debra Hoppensteadt, Walter Jeske, Ahmed Kouta, Caijuan Jin, Yongsheng Jin, Yiming Yao, Ke Xia, Fuming Zhang, Shiguo Chen, Xingqian Ye and Robert J. Linhardt in Clinical and Applied Thrombosis/Hemostasis</p
Single-cell RNA sequencing for characterizing the immune communication and iron metabolism roles in CD31+ glioma cells
No full textBackground: Gliomas are aggressive brain tumors marked by complex cellular interactions and significant immune cell infiltration. This study investigated the role of CD31+ immune cells, specifically macrophages and T cells, in the glioma microenvironment through single-cell RNA sequencing (scRNA-seq). Methods: We employed the CellChat framework to map cell-cell communication pathways and used Monocle3 for pseudotime trajectory analysis to characterize the signaling and developmental progressions within CD31+ cells. Pathways such as osteopontin (SPP1) and major histocompatibility complex class II (MHC-II) were analyzed in terms of their role in immune regulation, and we examined the expression of ferritin, an iron-binding protein, to assess its potential function in modulating CD31+ cell activity. Results: Our findings highlight the expression of key pathways, including SPP1 and MHC-II, influencing immune regulation. Ferritin was found to be highly expressed in CD31+ cells, suggesting a dual role in iron metabolism and immune modulation within the glioma microenvironment. Conclusions: This study clarified the distinct roles of CD31+ immune cells in glioma progression and identified ferritin as a potential therapeutic target for modulating immune responses in gliomas. These findings may offer new directions in glioma research and the development of immunotherapy, which can aid in improving treatment outcomes
CAR immunotherapy in autoimmune diseases: promises and challenges.
Full text linkIn recent years, the use of chimeric antigen receptor (CAR)-T cells has emerged as a promising immunotherapy in multiple diseases. CAR-T cells are T cells genetically modified to express a surface receptor, known as CAR, for the targeting of cognate antigens on specific cells. The effectiveness of CAR-T cell therapy in hematologic malignancies including leukemia, myeloma, and non-Hodgkins lymphoma has led to consider its use as a potential avenue of treatment for autoimmune diseases. However, broadening the use of CAR-T cell therapy to a large spectrum of autoimmune conditions is challenging particularly because of the possible development of side effects including cytokine release syndrome and neurotoxicity. The design of CAR therapy that include additional immune cells such as double-negative T cells, γδ T cells, T regulatory cells and natural killer cells has shown promising results in preclinical studies and clinical trials in oncology, suggesting a similar potential utility in the treatment of autoimmune diseases. This review examines the mechanisms, efficacy, and safety of CAR approaches with a focus on their use in autoimmune diseases including systemic lupus erythematosus, Sjögrens syndrome, systemic sclerosis, multiple sclerosis, myasthenia gravis, lupus nephritis and other autoimmune diseases. Advantages and disadvantages as compared to CAR-T cell therapy will also be discussed
Improvements and augmentations to Learning Based Java: a Java based learning based programming language
Full text linkMachine Learning (ML) is the science that enables computers with the ability to learn without being explicitly programmed. ML is so pervasive today, with applications in speech recognition, recommendation systems, fraud detection and many more that we may not be aware of. To facilitate a rapid pace of development, it is important to create a framework with modularity and reusability. Learning Based Java (LBJava) was introduced by Cognitive Computation Group (CCG) to achieve such goal.
This thesis extends and introduces multiple components in LBJava. We begin by giving a comprehensive literature review relates to Learning Based Programming (LBP) and LBJava.
Then we introduce regression evaluation metrics to LBJava. In addition, we introduce Adaptive Sub- Gradient (AdaGrad) for regression. Then we add a comprehensive tutorial with example on regression. Furthermore, we extend both SGD and AdaGrad algorithms for classification. Then we evaluate across var- ious learning algorithms, with sparse and dense features, using large programmatically generated datasets.
Moreover, we introduce Neural Network (NN), in particular, Multilayer Perceptron (MLP), to LBJava. We also did some miscellaneous work.
Lastly, we conclude on all the extended and added components and provide recommendations for future work.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01The student, Yiming Jiang, accepted the attached license on 2016-04-25 at 16:00.The student, Yiming Jiang, submitted this Thesis for approval on 2016-04-25 at 16:12.This Thesis was approved for publication on 2016-04-26 at 15:44.DSpace SAF Submission Ingestion Package generated from Vireo submission #9486 on 2016-07-07 at 13:50:51Made available in DSpace on 2016-07-07T20:28:02Z (GMT). No. of bitstreams: 2
JIANG-THESIS-2016.pdf: 281764 bytes, checksum: edda791770387b6e34f11d5fbea738fc (MD5)
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Previous issue date: 2016-04-26Embargo set by: Seth Robbins for item 93179
Lift date: 2018-07-07T20:28:14Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 93179
Lift date: 2018-07-07T20:35:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 93179 on 2018-07-08T09:15:20Z
RETRACTED ARTICLE: Study on the mechanical behavior of construction and demolition waste-based geopolymers under high-temperature conditions
No full textStatement of Retraction: Study on the mechanical behavior of construction and demolition waste-based geopolymers under high-temperature conditions We, the Editors and Publisher of Journal of Asian Architecture and Building Engineering, have retracted the following article: Yiming Chen (2025) Study on the mechanical behavior of construction and demolition waste-based geopolymers under high-temperature conditions, Journal of Asian Architecture and Building Engineering, 2025; 24(2): 650–665. DOI: 10.1080/13467581.2024.2308595. Since publication, significant concerns have been raised about the fact that this article has substantial overlap with the following article, Ioanna Giannopoulou, Ponsian M. Robert, Michael F. Petrou, Demetris Nicolaides (2024) Mechanical behavior of construction and demolition waste-based alkali activated materials exposed to fire conditions, Construction and Building Materials, DOI: 10.1016/j.conbuildmat.2024.134994 Upon query, the author has not been able to provide a satisfactory explanation for this significant level of overlap. As this is a serious breach of our Editorial Policies, we are retracting the article from the journal. The author has been informed of this decision. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’
Wu zhen zhi zhi: er juan.
No full text張眞人著 ; 劉一明解註 ; 張陽全校閱 ; 周金璽校正.綫裝, 1函.框17.5x12.7公分, 9行22字, 小字雙行同. 白口, 左右雙邊, 單黑魚尾. 版心上鐫題名, 中鐫卷次, 下鐫葉次.題名據內封頁.內封頁鐫"光緖庚辰年春月刊" ; 卷端題下鐫"李紫垣重刊"Xian zhuang, 1 han.Kuang 17.5 x 12.7 gong fen, 9 hang 22 zi, xiao zi shuang hang tong. Bai kou, zuo you shuang bian, dan hei yu wei. Ban xin shang juan ti ming, zhong juan juan ci, xia juan ye ci.Ti ming ju nei feng ye.Nei feng ye juan "Guangxu geng chen nian chun yue kan" ; juan duan ti xia juan "Li Ziyuan chong kan"Zhang zhen ren zhu ; Liu Yiming jie zhu ; Zhang Yangquan jiao yue ; Zhou jinxi jiao zheng
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